Paula T. Hammond

Modeling lung adenocarcinoma using layer-by-layer nanoparticles mitigates innate immune cell activation

Vidit Bhandarkar, Elen Torres-Mejia, Taylor Heim, Namita Nabar et autres

Lung adenocarcinoma, driven frequently by KRAS and p53 mutations, remains a leading cause of cancer mortality. Current state-of-the-art genetically engineered mouse models often rely on viral delivery of recombinases, such as Cre recombinase, to initiate transformation. However, viral particles can infect and …

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Layer-by-layer nanoparticle outer polyelectrolyte impacts protein corona formation

Tamara G. Dacoba, Simone A. Douglas-Green, Bhuvna Murthy, Alfonso D Restrepo et autres

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Polyamines buffer labile iron to suppress ferroptosis

Pushkal Sharma, Heather R. Keys, Ryan Mansell, Jillian Stark et autres

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Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith et autres

Diffuse midline glioma (DMG) is a highly aggressive pediatric brain tumor that is difficult to treat because the blood-brain-tumor barrier (BBTB) prevents most drugs from reaching the tumor. A major obstacle for understanding this tumor-vascular niche is the lack of a perfusable …

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Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor et autres

ABSTRACT Lipid nanoparticles (LNPs) have enabled the clinical translation of various nucleic acid cargos, including messenger RNA. Traditional LNP formulations contain a small proportion of lipids conjugated to poly(ethylene glycol), or PEG, which provides advantages of size control, stability, and extended circulation. …

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Systematic engineering of Layer-by-Layer anti-miR coated wound dressings with tunable release kinetics

Adam G. Berger, Chau Vo, Justin A. Kaskow, Shruti Rawal et autres

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Polymer Molecular Weight Influences Cancer Cell Surface Retention and Cytokine Presentation by Layer-by-Layer Nanoparticles

Ivan Susin Pires, Ezra Gordon, Aidan Kindopp, Alexander D. Stoneman et autres

Engineering the surface chemistry of nanoparticles (NPs) via the electrostatic layer-by-layer (LbL) assembly approach is a viable strategy for developing targeted drug delivery vehicles. However, how assembly solution conditions and polymer molecular weight (MW) govern LbL-NP properties remains poorly understood. We investigated …

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Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

Victoria F. Gomerdinger, Cassandra Parada, An Li, Aidan Kindopp et autres

Innate immune agonists are promising therapeutic agents to induce immune responses against cancer. However, these agents have been limited by toxicity associated with systemic accumulation and activity in off-target cells. In this work, a targeted nanoparticle (NP) platform to encapsulate and protect …

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Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy

Justin A. Kaskow, Altaf Bacchus, Victoria F. Gomerdinger, Adam G. Berger et autres

ABSTRACT Therapeutic activation of stimulator of interferon genes (STING) signaling shows promise as a method of inflaming the tumor microenvironment to generate an anti-cancer immune response. Frequent loss of STING expression in many human cancers renders small-molecule agonists ineffective in cancer cells. …

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A multivalent peptide-polymer conjugate material mimics STING to therapeutically activate innate immune signaling

Justin A Kaskow, Julia Treese, Anita Gaenko, Victoria F. Gomerdinger et autres

Stimulator of interferon genes (STING) is a promising therapeutic target for cancer immunotherapy, but agonists are often rendered ineffective by the loss of STING expression in cancer cells. Here we engineer a multivalent peptide-polymer conjugate material that can easily be delivered to …

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Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Abstract Tumor‐targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer‐by‐layer nanoparticles (LbL‐NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches—including gene expression analysis, receptor inhibition, …

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Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Tumor-targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer-by-layer nanoparticles (LbL-NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches-including gene expression analysis, receptor inhibition, and …

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