Accès ouvert
2026
article
OpenAlex
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor et autres
ABSTRACT Lipid nanoparticles (LNPs) have enabled the clinical translation of various nucleic acid cargos, including messenger RNA. Traditional LNP formulations contain a small proportion of lipids conjugated to poly(ethylene glycol), or PEG, which provides advantages of size control, stability, and extended circulation. …
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Accès ouvert
2025
article
OpenAlex
Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund et autres
Immunotherapies such as immune checkpoint inhibitors are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer. Here we engineered liposomal nanoparticles carrying a poly-ʟ-arginine/poly-ʟ-glutamate coating that promotes their binding and retention on the surface …
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Accès ouvert
2024
article
OpenAlex
Jignesh S. Mahajan, Zachary R. Hinton, Eduardo Nombera Bueno, Thomas H. III Epps et autres
, improved melt flow) for the bio-derivable NIPUs. These findings suggested that the added functionalities (methoxy groups) derived from lignin precursors improved thermomechanical stability while also offering increased processability. Altogether, the structure-property-processing relationships described in this work can help facilitate the development …
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