Namita Nabar

Modeling lung adenocarcinoma using layer-by-layer nanoparticles mitigates innate immune cell activation

Vidit Bhandarkar, Elen Torres-Mejia, Taylor Heim, Namita Nabar et autres

Lung adenocarcinoma, driven frequently by KRAS and p53 mutations, remains a leading cause of cancer mortality. Current state-of-the-art genetically engineered mouse models often rely on viral delivery of recombinases, such as Cre recombinase, to initiate transformation. However, viral particles can infect and …

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Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor et autres

ABSTRACT Lipid nanoparticles (LNPs) have enabled the clinical translation of various nucleic acid cargos, including messenger RNA. Traditional LNP formulations contain a small proportion of lipids conjugated to poly(ethylene glycol), or PEG, which provides advantages of size control, stability, and extended circulation. …

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Systematic engineering of Layer-by-Layer anti-miR coated wound dressings with tunable release kinetics

Adam G. Berger, Chau Vo, Justin A. Kaskow, Shruti Rawal et autres

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Subcellular nanoparticle trafficking investigated with label-free, live cell imaging

Elizabeth Bernice Nelson, Gil Covarrubias, Namita Nabar, Victoria F. Gomerdinger et autres

Nanoparticle drug delivery systems have significant potential to transform precision medicine due to their ability to encapsulate a wide range of cargo, improve systemic circulation time, and enhance targeted delivery. These delivery properties can be further modified by altering the surface chemistry …

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Advancing engineering design strategies for targeted cancer nanomedicine

Victoria F. Gomerdinger, Namita Nabar, Paula T. Hammond

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Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting

Tamara G. Dacoba, Namita Nabar, Paula T. Hammond

Abstract Effective delivery of drug and gene cargos to hematopoietic stem and progenitor cells (HSPCs) is a major challenge. Current therapeutic strategies in genetic disorders or hematological malignancies are hindered by high costs, low accessibility, and high off-target toxicities. Layer-by-layer nanoparticles (LbL …

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A Modular Layer-by-Layer Nanoparticle Platform for Hematopoietic Progenitor and Stem Cell Targeting

Tamara G. Dacoba, Namita Nabar, Paula T. Hammond

ABSTRACT Effective delivery of drug and gene cargos to hematopoietic stem and progenitor cells (HSPCs) is a major challenge. Current therapeutic strategies in genetic disorders or hematological malignancies are hindered by high costs, low accessibility, and high off-target toxicities. Layer-by-Layer nanoparticles (LbL …

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Poly(β-aminoester) Physicochemical Properties Govern the Delivery of siRNA from Electrostatically Assembled Coatings

Adam G. Berger, Charles DeLorenzo, Chau Vo, Justin A. Kaskow et autres

Localized short interfering RNA (siRNA) therapy has the potential to drive high-specificity molecular-level treatment of a variety of disease states. Unfortunately, effective siRNA therapy suffers from several barriers to its intracellular delivery. Thus, drug delivery systems that package and control the release …

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Abstract 492: Investigating solute carrier SLC46A3 to enhance nanotherapeutic delivery for cancer

Julianna Kenny-Serrano, Elizabeth B. Nelson, Gil Covarrubias, Namita Nabar et autres

Abstract BACKGROUND: Nanoparticle therapeutics have multifaceted potential to improve efficacy and decrease toxicity of cancer treatments. Nanotherapeutics can encapsulate a range of cargos and have tunable surface chemistry that can enhance drug delivery to tumors. Cellular features also play a role in …

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Electrostatic adsorption of polyanions onto lipid nanoparticles controls uptake, trafficking, and transfection of RNA and DNA therapies

Namita Nabar, Tamara G. Dacoba, Gil Covarrubias, Denisse Romero-Cruz et autres

Rapid advances in nucleic acid therapies highlight the immense therapeutic potential of genetic therapeutics. Lipid nanoparticles (LNPs) are highly potent nonviral transfection agents that can encapsulate and deliver various nucleic acid therapeutics, including but not limited to messenger RNA (mRNA), silencing RNA …

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129 Platform to conditionally induce lung tumors in genetically engineered mouse models using Cre mRNA containing nanoparticles

Vidit Bhandarkar, Elen Torres-Mejia, Namita Nabar, Tamara G. Dacoba et autres

Background Pre-clinical models are crucial for better understanding and treating human diseases such as cancer. Autochthonous models of lung cancer are excellent tools to study tumor progression and evolution. However, current approaches rely on intra-tracheal, viral delivery of Cre recombinase to initiate …

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Massively parallel pooled screening reveals genomic determinants of nanoparticle delivery

Natalie Boehnke, Joelle P. Straehla, Hannah C. Safford, Mustafa Kocak et autres

To accelerate the translation of cancer nanomedicine, we used an integrated genomic approach to improve our understanding of the cellular processes that govern nanoparticle trafficking. We developed a massively parallel screen that leverages barcoded, pooled cancer cell lines annotated with multiomic data …

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