Victoria F. Gomerdinger

Polymer Molecular Weight Influences Cancer Cell Surface Retention and Cytokine Presentation by Layer-by-Layer Nanoparticles

Ivan Susin Pires, Ezra Gordon, Aidan Kindopp, Alexander D. Stoneman et autres

Engineering the surface chemistry of nanoparticles (NPs) via the electrostatic layer-by-layer (LbL) assembly approach is a viable strategy for developing targeted drug delivery vehicles. However, how assembly solution conditions and polymer molecular weight (MW) govern LbL-NP properties remains poorly understood. We investigated …

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Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

Victoria F. Gomerdinger, Cassandra Parada, An Li, Aidan Kindopp et autres

Innate immune agonists are promising therapeutic agents to induce immune responses against cancer. However, these agents have been limited by toxicity associated with systemic accumulation and activity in off-target cells. In this work, a targeted nanoparticle (NP) platform to encapsulate and protect …

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Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy

Justin A. Kaskow, Altaf Bacchus, Victoria F. Gomerdinger, Adam G. Berger et autres

ABSTRACT Therapeutic activation of stimulator of interferon genes (STING) signaling shows promise as a method of inflaming the tumor microenvironment to generate an anti-cancer immune response. Frequent loss of STING expression in many human cancers renders small-molecule agonists ineffective in cancer cells. …

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Targeted Layer-by-Layer Nanoparticles for Therapeutic Delivery to Antigen Presenting Cells and Ovarian Cancer

Victoria F. Gomerdinger

Cancer is a devastating, complex disease driven by a multitude of biological and cellular factors. While there have been tremendous advancements in therapeutic strategies to target key vulnerabilities in cancer cells and the tumor microenvironment, the application of many promising agents has …

A multivalent peptide-polymer conjugate material mimics STING to therapeutically activate innate immune signaling

Justin A Kaskow, Julia Treese, Anita Gaenko, Victoria F. Gomerdinger et autres

Stimulator of interferon genes (STING) is a promising therapeutic target for cancer immunotherapy, but agonists are often rendered ineffective by the loss of STING expression in cancer cells. Here we engineer a multivalent peptide-polymer conjugate material that can easily be delivered to …

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Subcellular nanoparticle trafficking investigated with label-free, live cell imaging

Elizabeth Bernice Nelson, Gil Covarrubias, Namita Nabar, Victoria F. Gomerdinger et autres

Nanoparticle drug delivery systems have significant potential to transform precision medicine due to their ability to encapsulate a wide range of cargo, improve systemic circulation time, and enhance targeted delivery. These delivery properties can be further modified by altering the surface chemistry …

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IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer

Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund et autres

Immunotherapies such as immune checkpoint inhibitors are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer. Here we engineered liposomal nanoparticles carrying a poly-ʟ-arginine/poly-ʟ-glutamate coating that promotes their binding and retention on the surface …

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Advancing engineering design strategies for targeted cancer nanomedicine

Victoria F. Gomerdinger, Namita Nabar, Paula T. Hammond

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“Target-and-release” nanoparticles for effective immunotherapy of metastatic ovarian cancer

Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund et autres

Immunotherapies such as checkpoint inhibitors (CPI) are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer (OC). Here, we engineered liposomal nanoparticles (NPs) carrying a layer-by-layer (LbL) polymer coating that promotes their binding to …

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Synergistic combination therapy delivered via layer‐by‐layer nanoparticles induces solid tumor regression of ovarian cancer

Stephanie M. Kong, Pearl Moharil, Abram Handly‐Santana, Natalie Boehnke et autres

The majority of patients with high grade serous ovarian cancer (HGSOC) develop recurrent disease and chemotherapy resistance. To identify drug combinations that would be effective in treatment of chemotherapy resistant disease, we examined the efficacy of drug combinations that target the three …

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PEGylation of poly(amine-co-ester) polyplexes for tunable gene delivery

Molly K. Grun, Alexandra Suberi, Kwangsoo Shin, Teresa Lee et autres

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