Layer-by-layer nanoparticle outer polyelectrolyte impacts protein corona formation
Tamara G. Dacoba, Simone A. Douglas-Green, Bhuvna Murthy, Alfonso D Restrepo et autres
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0 citations
Biomaterials
Simone A. Douglas-Green
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10Publications signalées
8Citations signalées
3Affiliations récentes
Les institutions déclarées
Les domaines associés
Dendrimers and Hyperbranched PolymersOsteoarthritis Treatment and MechanismsPolymer Surface Interaction StudiesNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery
Les publications récentes
ProCAST: A Bioinformatics Suite for Mass Spectrometry-Based Protein Corona Proteomics Analysis
Huyju Mun, Maxwell Leamy, Anika Kaushik, Christopher Kieslich et autres
When nanoparticles are exposed to biological fluids, they spontaneously adsorb proteins, forming a protein corona that defines their biological identity and dictates cellular uptake, biodistribution, and toxicity. Characterizing protein coronas includes using proteomics approaches (e.g., LC-MS/MS) to identify proteins and generate vast …
us (code pays fourni par la source)
0 citations
bioRxiv (Cold Spring Harbor Laboratory)
PEG chains modulate electrostatic interactions between PAMAM and articular cartilage
Brandon Johnston, Simone A. Douglas-Green, Joon Ho Park, Alan Jay Grodzinsky et autres
us (code pays fourni par la source)
1 citation
Biomaterials
Cationic Dendrimer Nanoformulation Improves Therapeutic Efficacy of Pro-Anabolic and Anti-Catabolic Therapeutics in Osteoarthritis
Joon Ho Park, Brandon Johnston, Simone A. Douglas-Green, Zavian Strom et autres
Abstract Purpose Osteoarthritis (OA) is a debilitating disease characterized by degeneration of articular cartilage with no clinically approved treatment available to date despite the multitude of approaches that have been proposed. Two fundamentally different therapeutic strategies are pro-anabolic and anti-catabolic treatments. However, …
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1 citation
Regenerative Engineering and Translational Medicine
Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation
Tamara G. Dacoba, Simone A. Douglas-Green, Murthy BRN, Alfonso D Restrepo et autres
Abstract Nanoparticles (NPs) can be engineered to achieve targeted delivery with strategies based on surface modifications. These include layer-by-layer (LbL) NPs, modular electrostatically assembled carriers with tunable surface properties altered by changes to the outer polyion layer. Variations in these polymers dictate …
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3 citations
bioRxiv (Cold Spring Harbor Laboratory)
Investigating Bio-Nano Interactions of PEGylated Cationic Polyamidoamine (PAMAM) Dendrimers within Synovial Joints
Simone A. Douglas-Green, Juan A. Aleman, Victor M Dampty, Murthy BRN et autres
Abstract Delivering therapeutics directly to synovial joints to treat osteoarthritis (OA) is challenging due to the dense negatively charged cartilage matrix and rapid turnover of synovial fluid, leading to high clearance rates. Our lab has identified polyamidoamine (PAMAM) dendrimers as optimal nanocarriers …
us (code pays fourni par la source)
1 citation
bioRxiv (Cold Spring Harbor Laboratory)
Understanding the role of PEGylation on PAMAM’s drug delivery properties to articular cartilage
Brandon Johnston, Simone A. Douglas-Green, Joon Ho Park, Alan Jay Grodzinsky et autres
us (code pays fourni par la source)
0 citations
SSRN Electronic Journal
Electrophoresis-Based Approach for Characterizing Dendrimer–Protein Interactions: A Proof-of-Concept Study
Simone A. Douglas-Green, Juan A. Aleman, Paula T. Hammond
Improving the clinical translation of nanomedicine requires better knowledge about how nanoparticles interact with biological environments. As researchers are recognizing the importance of understanding the protein corona and characterizing how nanocarriers respond in biological systems, new tools and techniques are needed to …
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2 citations
ACS Biomaterials Science & Engineering
Abstract 1822 Deciphering the Proteomic Landscape: Understanding the Tumor Microenvironment in Diffuse Midline Glioma
Tessy Teboh, Kimberly J. Bennett, Simone A. Douglas-Green, Paula T. Hammond et autres
Diffuse midline glioma (DMG) is a uniformly fatal and aggressive brain tumor predominantly affecting children aged 2-10, with limited treatment options and no approved drugs available due to the blood-brain barrier (BBB) hindering effective therapeutic delivery. Despite extensive efforts, promising preclinical candidates …
us (code pays fourni par la source)
0 citations
Journal of Biological Chemistry
Electrophoresis-Based Approach for Characterizing Dendrimer-Protein Interactions: A Proof-of-Concept Study
Simone A. Douglas-Green, Juan A. Aleman, Paula T. Hammond
Abstract Improving the clinical translation of nanomedicine requires better knowledge about how nanoparticles interact with biological environments. As researchers are recognizing the importance of understanding the protein corona and characterizing how nanocarriers respond in biological systems, new tools and techniques are needed …
us (code pays fourni par la source)
0 citations
bioRxiv (Cold Spring Harbor Laboratory)
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