Alexander D. Stoneman

Layer-by-layer nanoparticle outer polyelectrolyte impacts protein corona formation

Tamara G. Dacoba, Simone A. Douglas-Green, Bhuvna Murthy, Alfonso D Restrepo et autres

us (code pays fourni par la source)

Polymer Molecular Weight Influences Cancer Cell Surface Retention and Cytokine Presentation by Layer-by-Layer Nanoparticles

Ivan Susin Pires, Ezra Gordon, Aidan Kindopp, Alexander D. Stoneman et autres

Engineering the surface chemistry of nanoparticles (NPs) via the electrostatic layer-by-layer (LbL) assembly approach is a viable strategy for developing targeted drug delivery vehicles. However, how assembly solution conditions and polymer molecular weight (MW) govern LbL-NP properties remains poorly understood. We investigated …

us (code pays fourni par la source)

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy

Victoria F. Gomerdinger, Cassandra Parada, An Li, Aidan Kindopp et autres

Innate immune agonists are promising therapeutic agents to induce immune responses against cancer. However, these agents have been limited by toxicity associated with systemic accumulation and activity in off-target cells. In this work, a targeted nanoparticle (NP) platform to encapsulate and protect …

us (code pays fourni par la source)

Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. Int. Ed. 8/2026)

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

In their Research Article (e19203), Darrell J. Irvine, Paula T. Hammond, and co-workers uncover that the dense presentation of anionic amino-acid motifs on layer-by-layer nanoparticles (green) enables selective recognition of amino-acid transporters on cancer cells (pink; blue nucleus; white indicates NP–receptor colocalization). …

us (code pays fourni par la source)

Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. 8/2026)

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

us (code pays fourni par la source)

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Abstract Tumor‐targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer‐by‐layer nanoparticles (LbL‐NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches—including gene expression analysis, receptor inhibition, …

us (code pays fourni par la source)

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Tumor-targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer-by-layer nanoparticles (LbL-NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches-including gene expression analysis, receptor inhibition, and …

us (code pays fourni par la source)

Surface avidity of anionic polypeptide coatings target nanoparticles to cancer-associated amino acid transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

ABSTRACT Tumor-targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer-by-layer nanoparticles (LbL-NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches—including gene expression analysis, receptor inhibition, …

ru, us (code pays fourni par la source)

Generalized Strategy for Engineering Mammalian Cell-Compatible RNA-Based Biosensors from Random Sequence Libraries

Everett R. Allchin, Jonah C. Rosch, Alexander D. Stoneman, Hyosung Kim et autres

Fluorescent RNA-based biosensors are useful tools for real-time detection of molecules in living cells. These biosensors typically consist of a chromophore-binding aptamer and a target-binding aptamer, whereby the chromophore-binding aptamer is destabilized until a target is captured, which causes a conformational change …

us (code pays fourni par la source)

Effects of Player-Level Matchmaking Methods in a Live Citizen Science Game

Alexander D. Stoneman, Josh Aaron Miller, Seth Cooper

Citizen science games must balance task difficulty with player skill to ensure optimal engagement and performance. This issue has been previously addressed via player-level matchmaking, a dynamic difficulty adjustment method in which player and level ratings are used to present levels best …

us, mx (code pays fourni par la source)