Andrew J. Pickering

Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. Int. Ed. 8/2026)

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

In their Research Article (e19203), Darrell J. Irvine, Paula T. Hammond, and co-workers uncover that the dense presentation of anionic amino-acid motifs on layer-by-layer nanoparticles (green) enables selective recognition of amino-acid transporters on cancer cells (pink; blue nucleus; white indicates NP–receptor colocalization). …

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Outside Front Cover: Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters (Angew. Chem. 8/2026)

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

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Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Abstract Tumor‐targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer‐by‐layer nanoparticles (LbL‐NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches—including gene expression analysis, receptor inhibition, …

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Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Ivan Susin Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering et autres

Tumor-targeted drug delivery enhances therapeutic efficacy while minimizing toxicity. Layer-by-layer nanoparticles (LbL-NPs) coated with anionic polypeptides selectively bind to cancer cells, though the mechanisms have been unclear. Here, we integrated in silico and in vitro approaches-including gene expression analysis, receptor inhibition, and …

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Charge‐Stabilized Nanodiscs as a New Class of Lipid Nanoparticles

Ivan Susin Pires, Alexander Hostetler, Gil Covarrubias, Isabella S. Carlo et autres

Nanoparticles have the potential to improve disease treatment and diagnosis due to their ability to incorporate drugs, alter pharmacokinetics, and enable tissue targeting. While considerable effort is placed on developing spherical lipid-based nanocarriers, recent evidence suggests that high aspect ratio lipid nanocarriers …

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Core material and surface chemistry of Layer-by-Layer (LbL) nanoparticles independently direct uptake, transport, and trafficking in preclinical blood-brain barrier (BBB) models

Nicholas G. Lamson, Andrew J. Pickering, Jeffrey B. Wyckoff, Priya Ganesh et autres

Abstract Development of new treatments for neurological disorders, especially brain tumors and neurodegenerative diseases, is hampered by poor accumulation of new therapeutic candidates in the brain. Drug carrying nanoparticles are a promising strategy to deliver therapeutics, but there is a major need …

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Surface Presentation of Hyaluronic Acid Modulates Nanoparticle–Cell Association

Elad Deiss‐Yehiely, Spencer D. Brucks, Natalie Boehnke, Andrew J. Pickering et autres

Nanoparticle (NP) drug carriers have revolutionized medicine and increased patient quality of life. Clinically approved formulations typically succeed because of reduced off-target toxicity of the cargo. However, increasing carrier accumulation at disease sites through precise targeting remains one of the biggest challenges …

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