Wei Xiong

Activating transcription factor 3 aggravates renal fibrosis by regulating EGR2-mediated autophagy

Ruiwei Yan, Anni Song, Mingcun Hu, Xingjie Yin et autres

hk, cn (code pays fourni par la source)

Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis

Jia-Shiun Leu, Hui Deng, Han Nhat Tran, Wei Xiong et autres

us (code pays fourni par la source)

295 CD276-mediated fratricide limits CD276-CAR-T cell fitness

Wei Xiong, Peirong Hu, Michael Wagner, Sayyed Hamid Zarkesh‐Esfahani et autres

Background B7-H3 (CD276), a member of the B7 family, is a compelling therapeutic target due to its selective expression on tumor cells and immune cells within the tumor microenvironment. 1 Our previous work identified CD276 as an activation marker in CD276-CAR-T cells2; …

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BTK Inhibitor Synergizes With CD19 ‐Targeted Chimeric Antigen Receptor‐T Cells in Patients With Relapsed or Refractory B‐Cell Lymphoma: An Open‐Label Pragmatic Clinical Trial

Wenjing Luo, Yinqiang Zhang, Chenggong Li, Jia Xu et autres

BACKGROUND: CD19-targeted chimeric antigen receptor-T cell (CART19) therapy is clinically effective in patients with relapsed or refractory B-cell lymphoma (BCL), but treatment failure and recurrence need to be overcome. Preclinical studies demonstrated that Bruton tyrosine kinase inhibitor (BTKi) improved the efficacy of …

cn (code pays fourni par la source)

Treatment of Cutaneous Lupus Erythematosus: An Evidence-Based Review

Wei Xiong, Lili Fu, Jie Yi, Jiantang Yang

INTRODUCTION: Cutaneous lupus erythematosus (CLE) is a chronic and recurrent autoimmune disorder that predominantly affects the skin. It may cause alterations in appearance and psychological distress, thereby exerting an impact on the quality of life. Consequently, the pursuit of safer, more effective, …

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Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Jieqing Fan, Danyang Liu, Huaixin Dang, Yanfang Pan et autres

Abstract ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 …

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Secretogranin 2 binds LILRB4 resulting in immunosuppression

Ryan Yuki Huang, Meng Fang, Yubo He, Jingjing Xie et autres

us (code pays fourni par la source)

Resilience and adaptive strategies for managing stigma in Chinese people with chronic kidney disease

Wei Xiong, Tianhui An

Chronic kidney disease (CKD) is a significant global public health issue, with a substantial population in China. Influenced by traditional Chinese medicine that links kidney health to sexual vitality, people with CKD in China face unique societal stigmatization. This study aimed to …

cn, hk (code pays fourni par la source)

Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature

Xindi Wang, Wenjing Luo, Zhaozhao Chen, Chenggong Li et autres

BACKGROUND: Chimeric antigen receptor (CAR)-natural killer (NK) cell therapy has demonstrated safety and feasibility in clinical settings; however, limited efficacy due to intrinsic dysfunction and extrinsic suppression remains an unresolved issue. T cells provide multifaceted support to NK cell-mediated responses. Here, we …

hk, cn (code pays fourni par la source)

Abstract 4999: Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

Yanxin Ren, Wei Xiong, Chun Feng, Dan Yu et autres

Abstract Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) are diagnosed in advanced stage, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients who need aggressive treatment is crucial. We present mutational, transcriptomic and …

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Adoptively transferred tumor-specific IL-9-producing cytotoxic CD8+ T cells activate host CD4+ T cells to control tumors with antigen loss

Liuling Xiao, Rui Duan, Wendao Liu, Chuanchao Zhang et autres

us, cn (code pays fourni par la source)

Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

Yanxin Ren, Wei Xiong, Chun Feng, Dan Yu et autres

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic …

cn, hk, cz, us, sa (code pays fourni par la source)