Jieqing Fan

Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Jieqing Fan, Danyang Liu, Huaixin Dang, Yanfang Pan et autres

Abstract ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 …

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Simulation study on the synergistic radiation effects of typical functional devices

Jianhong Hao, Zhiyuan Zhang, Ke Li, Qiang Zhao et autres

Abstract In a radiation environment, functional devices may be simultaneously influenced by different irradiation effects, with single-event effects and total ionizing dose effects being significant factors affecting device performance. However, the mechanisms and interactions between these two modes of radiation damage remain …

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Complex Airport Radiation Effect: Computational Modeling Research

Haoyang Wang, Jianhong Hao, Jieqing Fan, Fang Zhang et autres

The secondary effects of high-altitude nuclear explosions, such as neutrons, gamma rays, X-rays, and charged particles transported in the atmosphere, can cause radiation damage to important facilities and personnel such as airports. The Monte Carlo (MC) method can simulate the interaction between …

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Modeling Analysis and Research of Terahertz Wave Propagation Experiment at Sea

Xiangchun Cao, Juan Liu, Jianhong Hao, Qiang Zhao et autres

In this paper, the propagation loss of 0.14 THz signal propagating for 27 km at sea is measured experimentally and compared with the simulation results of model in International Telecommunication Union-Radiocommunication Sector (ITU-R). The results show that the average difference between the …

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Terahertz Transmission Characteristics for UAV Swarm on Atmosphere-Limited Line-of-sight Links Under Complex Meteorological Conditions

Xiangchun Cao, Jianhong Hao, Qiang Zhao, Fang Zhang et autres

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Surface Unequal Charging Effect of GEO Satellite

Jianhong Hao, Biao Ru, Jieqing Fan

When a satellite is in orbit, the plasma environment interacts with the surface material, and the surface charge accumulation of different structures is inconsistent,resulting in an unequal charging effect. In serious cases, this leads to electrostatic discharge and affects the normal operation …

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Analysis of displacement damage mechanism and simulation proton irradiation on GaAs

Jieqing Fan, Qun Tan, Jianhong Hao

GaAs is an important material for preparing power supply for space vehicles, satellites, and space systems. To study the displacement damage of GaAs material caused by protons in the space environment, in this article, the Monte Carlo software Geant4 was used to …

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Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B

Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi et autres

BACKGROUND AND AIMS: In the treatment of chronic hepatitis B (CHB) infection, stimulation of innate immunity may lead to hepatitis B virus (HBV) cure. Alpha-kinase 1 (ALPK1) is a pattern recognition receptor (PRR) that activates the NF-κB pathway and stimulates innate immunity. …

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Analysis of High-Frequency Atmospheric Windows for Terahertz Transmission Along Earth-Space Paths

Xiangchun Cao, Jianhong Hao, Qiang Zhao, Fang Zhang et autres

The atmospheric absorption effect greatly increases the transmission loss of terahertz (THz) waves, which limits the transmission distance. In this article, with the support of sufficient antenna gain, a series of high-frequency THz transmission windows in the ground-satellite link are presented. First, …

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Axial effect analysis of relativistic electron beam propagation in vacuum

Xi Wang, Jianhong Hao, Fang Zhang, Qiang Zhao et autres

Abstract In geostationary orbits and other quasi-vacuum environments, relativistic electron beams are affected by the initial emittance and space charge effects during the propagation process, resulting in beam quality degradation. Furthermore, axial energy distribution change in the beam and the axial transient …

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Ion-focused propagation of a relativistic electron beam in the self-generated plasma in atmosphere

Jianhong Hao, Bixi Xue, Qiang Zhao, F. S. Zhang et autres

It is known that ion-focused regime (IFR) can effectively suppress expansion of a relativistic electron beam (REB). Using the particle-in-cell Monte Carlo collision (PIC-MCC) method, we numerically investigate the propagation of an REB in neutral gas. The results demonstrate that the beam …

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Influence of Power Frequency Magnetic Field Interference in Substation on 5G Base Station Deployment

Hai Chuan Niu, Jieqing Fan, Tian Hao Hou