Meng Fang

MG53 suppresses IRF7 to reprogram macrophages and promote antitumor immunity in pancreatic ductal adenocarcinoma

Yumeng Pei, Meng Fang, Fan Zhang, Danyang Zhao et autres

In pancreatic ductal adenocarcinoma (PDAC), the desmoplastic stroma and immunosuppressive tumor microenvironment (TME) present barriers to immunotherapy. Here, we show that MG53 (TRIM72) is a critical regulator of macrophage fate and anti-tumor immunity; its myeloid-specific depletion accelerates PDAC progression by locking macrophages …

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Leukocyte immunoglobulin-like receptor A3 inhibits the activity of immunosuppressive myeloid cells

Meng Fang, Xing Yang, Jingjing Xie, Qi Lou et autres

Myeloid checkpoint blockade as monotherapy often yields limited benefit, suggesting that multiple inhibitory pathways cooperatively sustain myeloid immunosuppression in the tumor microenvironment (TME). However, strategies to concurrently target multiple myeloid checkpoints remain challenging. Leukocyte immunoglobulin-like receptor A3 (LILRA3) is a soluble LILRA/B …

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MAGEA1 drives tumor progression via activation of the AKT pathway and correlates with elevated radiosensitivity in lung adenocarcinoma

Meng Fang, Qi Zhu, Shiqiang Zhang

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Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer

Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie et autres

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 …

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A pan-cancer single-cell transcriptomic atlas of human bone metastases

Shuoer Wang, Fen Ma, Dongliang Wang, Qian Yu et autres

Bone is a common site for cancer metastasis, yet the mechanisms driving human spinal bone metastases (BMs) are poorly understood. Here, we obtained a single-cell RNA sequencing (scRNA-seq) atlas of 62 BMs across 13 different origins, along with paired primary tumor and …

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Secretogranin 2 binds LILRB4 resulting in immunosuppression

Ryan Yuki Huang, Meng Fang, Yubo He, Jingjing Xie et autres

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Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation

Yumeng Pei, Meng Fang, Hongkun Wu, Qionghua Cui et autres

Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD). However, the mechanism driving such biased lineage commitment remains elusive. Here we show that MG53, also named as …

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Data from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Abstract Immunosuppressive myeloid cells are critical obstacles to T cell–centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. …

Figure S6 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S6. EphB1 expression on tumor cells promotes T cell exhaustion in LILRB5 transgenic mice.

Figure S1 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S1. Eph receptors do not bind to LILRB1, LILRB3, LILRB4 and LAIR1.

Supplementary Tables 1-5 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Supplementary Tables S1-S5

Figure S2 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S2. LILRB5-ECD induces EphB1 phosphorylation.