Xindi Wang

Nat10-mediated ac4C modification sustains macrophage proliferation and mitigates colitis progression via Mcm2 stabilization

Jinsong Wang, Tao Liu, Jiachen Zhao, Zhiqing Diao et autres

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High IL ‐10 levels during CRS are negatively associated with NK ‐cell recovery after CAR ‐T cell therapy

Xindi Wang, Wenjing Luo, Yingying Li, Jianghua Wu et autres

Abstract Objectives Immune reconstitution following chimeric antigen receptor (CAR)‐T cell therapy remains a critical clinical challenge, and the determinants of natural killer (NK)‐cell recovery are not fully understood. Methods We longitudinally monitored natural killer (NK)‐cell recovery in 64 patients during the first …

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Ray-tracing–guided FS-LASIK Using Mi Optimized Strategies

Yimeng Fan, Xindi Wang, Lei Luo, Yu Zhang et autres

Purpose: To evaluate the clinical outcomes of ray-tracing–guided femtosecond laser–assisted laser in situ keratomileusis (FS-LASIK) in the patients with a difference of greater than 0.50 diopters (D) between subjective and wavefront refractions at the corneal plane. Methods: This retrospective study included 80 …

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Bone marrow blasts- and modified EASIX-guided risk stratification for coagulopathy and outcomes after CAR-T therapy in relapsed/refractory B-ALL

Yingying Li, Jiachen Liu, Lili Luo, Lijuan Zhou et autres

BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL). While CAR-T-associated coagulopathy (CARAC) remains a critical complication, significantly increasing the risk of hemorrhage and disseminated intravascular coagulation (DIC). AIMS: To develop an …

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A predictive framework leveraging integration site profiling to stratify CAR-T response in Relapsed/Refractory multiple myeloma

Yun Jee Kang, Shuai Ni, Zhihan Chen, Yinqiang Zhang et autres

Abstract Introduction Chimeric antigen receptor (CAR) T-cell therapy has revolutionized treatment for relapsed/refractory multiple myeloma (R/R MM), yet durable responses remain unavailable and lack of biomarker. Lentiviral and retroviral vectors used in CAR-T manufacturing integrate into the host genome at specific sites, …

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Corneal epithelial remodeling following myopic ray-tracing-guided laser-assisted in situ keratomileusis: A clinical study

Lei Luo, Yimeng Fan, Xindi Wang, Linjuan Yang et autres

PURPOSE: To evaluate corneal epithelial remodeling profile following ray-tracing-guided laser-assisted in situ keratomileusis (LASIK) for myopia. METHODS: This retrospective study enrolled 65 eyes from 33 patients undergoing ray-tracing-guided LASIK for myopia. Corneal epithelial thickness (CET) was measured across a 9-mm diameter area …

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Comparison of regional differences in safety and efficacy of CAR-T therapy for hematologic malignancies in a real-world setting: a systematic review and meta-analysis

Zhihan Chen, Yun Jin Kang, Jia Xu, Chenggong Li et autres

BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy has transformed the treatment landscape of patients with hematologic malignancies. Nevertheless, geographic regions may lead to various outcomes, including cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), overall response rate (ORR), and complete …

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BTK Inhibitor Synergizes With CD19 ‐Targeted Chimeric Antigen Receptor‐T Cells in Patients With Relapsed or Refractory B‐Cell Lymphoma: An Open‐Label Pragmatic Clinical Trial

Wenjing Luo, Yinqiang Zhang, Chenggong Li, Jia Xu et autres

BACKGROUND: CD19-targeted chimeric antigen receptor-T cell (CART19) therapy is clinically effective in patients with relapsed or refractory B-cell lymphoma (BCL), but treatment failure and recurrence need to be overcome. Preclinical studies demonstrated that Bruton tyrosine kinase inhibitor (BTKi) improved the efficacy of …

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αPD-L1–γδ T cell conjugates: expanding function beyond direct tumor killing

Xindi Wang, Peng Wu

Xindi Wang, Peng Wu; αPD-L1–γδ T cell conjugates: expanding function beyond direct tumor killing, National Science Review, , nwaf358, https://doi.org/10.10

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Ray tracing-guided LASIK for high myopia and astigmatism: Initial clinical outcomes

Yimeng Fan, Xindi Wang, Linjuan Yang, Yu Zhang et autres

OBJECTIVE: To evaluate visual acuity, refractive outcomes and ocular higher order aberrations (HOAs) following ray tracing-guided laser-assisted in situ keratomileusis (LASIK) for high myopia and astigmatism. METHODS: This retrospective study enrolled 77 eyes in 42 patients with high myopia and astigmatism undergoing …

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Selinexor Reduces the Immunosuppression of Macrophages and Synergizes With CD19 CAR ‐T Cells Against B‐Cell Lymphoma

Wenjing Luo, Jia Xu, Chenggong Li, Lu Tang et autres

CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved high response rates in patients with B-cell lymphoma. However, treatment failure and relapse can be attributable to CAR-T cell dysfunction and the immunosuppression of the tumor microenvironment. Combination therapy emerges as a solution …

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Co-expression of IL-15 and CCL21 strengthens CAR-NK cells to eliminate tumors in concert with T cells and equips them with PI3K/AKT/mTOR signal signature

Xindi Wang, Wenjing Luo, Zhaozhao Chen, Chenggong Li et autres

BACKGROUND: Chimeric antigen receptor (CAR)-natural killer (NK) cell therapy has demonstrated safety and feasibility in clinical settings; however, limited efficacy due to intrinsic dysfunction and extrinsic suppression remains an unresolved issue. T cells provide multifaceted support to NK cell-mediated responses. Here, we …

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