Chun Feng

Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling

Qishan Chen, Ya Yu, Qiaohang Zhao, Danqing Yu et autres

The global incidence of obesity-related metabolic disorders and their comorbidities continue to increase along with a demand for innovative therapeutic interventions. An in-depth understanding of de novo thermogenic adipogenesis is vital to harness the potential of these adipocytes. Here, we combine genetic …

cn (code pays fourni par la source)

Abstract 4999: Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

Yanxin Ren, Wei Xiong, Chun Feng, Dan Yu et autres

Abstract Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) are diagnosed in advanced stage, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients who need aggressive treatment is crucial. We present mutational, transcriptomic and …

cn, hk, us (code pays fourni par la source)

Multi-omics insights into the molecular signature and prognosis of hypopharyngeal squamous cell carcinoma

Yanxin Ren, Wei Xiong, Chun Feng, Dan Yu et autres

Approximately two-thirds of hypopharyngeal squamous cell carcinoma (HPSCC) cases are diagnosed at advanced stages, with the worst prognosis among head and neck squamous cell carcinomas (HNSCCs). Identifying biomarkers for high-risk patients requiring aggressive treatment is crucial. We present mutational, transcriptomic, and proteomic …

cn, hk, cz, us, sa (code pays fourni par la source)

Translation and cultural adaption of MacLeod Clark professional identity scale among Chinese therapy students

Xiaoyi Shu, Chun Feng, Chak-Lam Ip, Xin Zhang et autres

BACKGROUND: Fostering a strong professional identity (PI) enhances career fulfillment. In China, therapy education is undergoing development, integrating both Western and traditional health concepts, causing inconsistent PI among therapy students. To date, no validated tools exist to measure and monitor PI of …

gb, cn (code pays fourni par la source)

MacLeod Clark Professional Identity Scale--Chinese Version

Xiaoyi Shu, Chun Feng, Chak-Lam Ip, Xin Zhang et autres

The impact of dynamic caudal type homeobox 2 expression on the differentiation of human trophoblast lineage during implantation

Lujuan Rong, Lifeng Xiang, Zongyong Ai, Yaqing Wang et autres

The trophoblast lineage differentiation represents a rate-limiting step in successful embryo implantation. Adhesion, invasion and migration processes within the trophoblast are governed by several transcription factors. Among them, CDX2 is a critical regulator shaping the destiny of the trophoblast. While its altered …

cn (code pays fourni par la source)

Hydrogel encapsulated stem cells facilitate successful repair after spinal cord injury in rats and monkeys

Tianqing Li, Pengfei Li, Hao Yuan, Yanyin chen et autres

Abstract Promoting axonal regeneration to form nascent circuits after spinal cord injury (SCI) is a considerable challenge. While cell-based transplantation is considered a top candidate for SCI therapeutics, limited anatomical structure repair and slight functional recovery have prevented translation to the clinic. …

cn (code pays fourni par la source)

Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson’s disease in animal models

Jun Li, Nan Li, Jingkuan Wei, Chun Feng et autres

Although striatal delivery of three critical genes for dopamine synthesis by viruses is a potential clinical approach for treating Parkinson's disease (PD), the approach makes it difficult to finely control dopamine secretion amounts and brings safety concerns. Here, we generate genetically engineered …

cn (code pays fourni par la source)

Exosomes derived from human placental mesenchymal stem cells enhanced the recovery of spinal cord injury by activating endogenous neurogenesis

Wenshu Zhou, Marta Silva, Chun Feng, Shumei Zhao et autres

Abstract Background Spinal cord injury (SCI) is a debilitating medical condition that can result in the irreversible loss of sensorimotor function. Current therapies fail to provide an effective recovery being crucial to develop more effective approaches. Mesenchymal stem cell (MSC) exosomes have …

mo, cn (code pays fourni par la source)

Triple-negative breast cancer cells respond to T cells severely at the alternative splicing layer

Lina Zhao, Xi Yang, Chun Feng, Yue Wang et autres

Cross talk of tumor–immune cells at the gene expression level has been an area of intense research. However, it is largely unknown at the alternative splicing level which has been found to play important roles in the tumor–immune microenvironment. Here, we re-exploited …

cn (code pays fourni par la source)

Modulation of Wnt and Activin/Nodal supports efficient derivation, cloning and suspension expansion of human pluripotent stem cells

Zongyong Ai, Kui Duan, Chenyang Si, Sile Wang et autres

cn (code pays fourni par la source)

Parameter optimization of a double-deflector rectangular cambered otter board: Numerical simulation study

Qing Chang Xu, Chun Feng, Liu Yi Huang, Ji Qiang Xu et autres

cn (code pays fourni par la source)