Yanfang Pan

The Underlying Mechanism of Shanxian Granule in the Treatment of Glioma Based on Network Pharmacological and Bioinformatics Analysis

Xiaoya Wang, Fangzheng Jiao, Yifan Qiao, Zihan Yuan et autres

INTRODUCTION: In the clinic, the herbal compound Shanxian Granule (SXG) is widely used as an adjuvant for cancer therapy. However, its role in glioma is unclear. The study aims to predict the underlying pharmacological function of SXG on glioma by network pharmacology …

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Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Jieqing Fan, Danyang Liu, Huaixin Dang, Yanfang Pan et autres

Abstract ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 …

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High Expression of ZNF208 Predicts Better Prognosis and Suppresses the Tumorigenesis of Breast Cancer

Jing Wei, Xiaoya Wang, Yifan Qiao, Zihan Yuan et autres

Background: Breast cancer (BRCA), the hormone related malignant tumor, is well-known for poor prognosis. ZNF208 mainly acts as a transcription factor in various tumors, and the single nucleotide polymorphisms (SNPs) of ZNF208 are related to telomere length. Nevertheless, its role in breast …

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Unique Tridentate Coordination Tailored Solvation Sheath Toward Highly Stable Lithium Metal Batteries

Junru Wu, Ziyao Gao, Yao Tian, Yun Zhao et autres

Abstract Electrolyte optimization by solvent molecule design is recognized as an effective approach for stabilizing lithium (Li) metal batteries. However, the coordination pattern of Li ions (Li+) with solvent molecules is sparsely considered. Here, an electrolyte design strategy is reported based on …

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Holistic analysis of lysine acetylation in aquaculture pathogenic bacteria Vibrio alginolyticus under bile salt stress

Xing Xiao, Wanxin Li, Yanfang Pan, Junlin Wang et autres

Lysine acetylation modification is a dynamic and reversible post-translational modification, which plays an important role in the metabolism and pathogenicity of pathogenic bacteria. Vibrio alginolyticus is a common pathogenic bacterium in aquaculture, and bile salt can trigger the expression of bacterial virulence. …

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Boosting the Li| LAGP interfacial compatibility with trace nonflammable all‐fluorinated electrolyte: The role of solid electrolyte interphase

Qi Liu, Jiahao Yu, Weiqian Guo, Yanfang Pan et autres

Abstract NASCION‐type lithium (Li) conductors provide a great chance to break the challenges of solid‐state lithium batteries (SSLBs) emphasizing superior safety and high energy density. Nonetheless, their practical employment has been hampered by the poor interfacial compatibility. Herein, we successfully block interfacial …

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Ethanol Fumigation Combined with Modified Atmosphere Packaging Delays Potato Greening Under Light

jixing tang, Zhixuan LI, Jiadi ZHANG, Yanfang Pan

Innovative natural antimicrobial natamycin incorporated titanium dioxide (nano-TiO2)/ poly (butylene adipate-co-terephthalate) (PBAT) /poly (lactic acid) (PLA) biodegradable active film (NTP@PLA) and application in grape preservation

Yanli Zheng, Xiaoyu Jia, Zhiyong Zhao, Yalin Ran et autres

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Simulation and Efficiency Optimization Algorithm of Virtual Logistics Transmission Network based on RFID Tag

Dalong Liu, Yanfang Pan, Yanxuan Li, Zhong Zheng

Simulation and efficiency optimization algorithm of virtual logistics transmission network based on RFID tag is designed and implemented in the paper. Before studying the service quality of logistics assurance network, it is necessary to clarify the definition of logistics assurance network service …

Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B

Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi et autres

BACKGROUND AND AIMS: In the treatment of chronic hepatitis B (CHB) infection, stimulation of innate immunity may lead to hepatitis B virus (HBV) cure. Alpha-kinase 1 (ALPK1) is a pattern recognition receptor (PRR) that activates the NF-κB pathway and stimulates innate immunity. …

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Research on non-destructive testing technology of hydraulic engineering based on improved ALO algorithm and wireless network

Chenghua Fu, Yanfang Pan, Haoran Shi

The anti-seepage wall project is an important part of the anti-seepage system of water conservancy and hydropower projects, and it is the basic facility and barrier to resist floods and ensure the safety of people's lives and property. This paper analyzes the …

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Prognostic significance of peritumoural and intratumoural budding in intestinal-type gastric adenocarcinoma

Baoning Qi, Longzhu Liu, Yanfang Pan, Shouzhu Xu et autres

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