Huaixin Dang

Discovery of a selective alpha-kinase 1 inhibitor for the rare genetic disease ROSAH syndrome

Jieqing Fan, Danyang Liu, Huaixin Dang, Yanfang Pan et autres

Abstract ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 …

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Association of the Controlling Nutritional Status (CONUT) score with all-cause and cause-specific mortality in patients with diabetic kidney disease: evidence from the NHANES 2009–2018

Huifeng Zhang, Na Liu, Huaixin Dang

OBJECTIVE: To investigate the association between the Controlling Nutritional Status (CONUT) score and all-cause and cause-specific mortality in patients with diabetic kidney disease (DKD). DESIGN: A retrospective cohort study. SETTING AND PARTICIPANTS: Data on patients with DKD from the National Health and …

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Alpha‐kinase 1 (ALPK1) agonist DF‐006 demonstrates potent efficacy in mouse and primary human hepatocyte (PHH) models of hepatitis B

Cong Xu, Jieqing Fan, Danyang Liu, Aimaier Tuerdi et autres

BACKGROUND AND AIMS: In the treatment of chronic hepatitis B (CHB) infection, stimulation of innate immunity may lead to hepatitis B virus (HBV) cure. Alpha-kinase 1 (ALPK1) is a pattern recognition receptor (PRR) that activates the NF-κB pathway and stimulates innate immunity. …

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Inhibition of Soluble Epoxide Hydrolase Attenuates High-Fat-Diet–Induced Hepatic Steatosis by Reduced Systemic Inflammatory Status in Mice

Yan Liu, Huaixin Dang, Dan Li, Wei Pang et autres

Non-alcoholic fatty liver disease is associated with obesity and considered an inflammatory disease. Soluble epoxide hydrolase (sEH) is a major enzyme hydrolyzing epoxyeicosatrienoic acids and attenuates their cardiovascular protective and anti-inflammatory effects. We examined whether sEH inhibition can protect against high-fat (HF)-diet-induced …

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Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance

Hong Soon Kang, Kyoko Okamoto, Yong-Sik Kim, Yukimasa Takeda et autres

OBJECTIVE: The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. In this study, we investigate whether TAK1 functions as a regulator of lipid and energy homeostasis and has a role in metabolic syndrome. …

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Down-Regulation of Hepatic HNF4α Gene Expression during Hyperinsulinemia via SREBPs

Xuefen Xie, Hailing Liao, Huaixin Dang, Wei Pang et autres

Mutations in the coding region of hepatocyte nuclear factor 4alpha (HNF4alpha), and its upstream promoter (P2) that drives expression in the pancreas, are known to lead to maturity-onset diabetes of the young 1 (MODY1). HNF4alpha also controls gluconeogenesis and lipid metabolism in …

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Suppression of 2,3-Oxidosqualene Cyclase by High Fat Diet Contributes to Liver X Receptor-α-mediated Improvement of Hepatic Lipid Profile

Huaixin Dang, Yan Liu, Wei Pang, Chenghong Li et autres

The liver X receptors (LXRs) sense oxysterols and regulate genes involved in cholesterol metabolism. Synthetic agonists of LXRs are potent stimulators of fatty acid synthesis, which is mediated largely by sterol regulatory element-binding protein-1c (SREBP-1c). Paradoxically, an improved hepatic lipid profile by …

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Suppression of 2,3-Oxidosqualene Cyclase by High Fat Diet Contributes to Liver X Receptor--mediated Improvement of

Huaixin Dang, Yan Liu, Wei Pang, Chenghong Li et autres

The liver X receptors (LXRs) sense oxysterols and regulategenesinvolvedincholesterolmetabolism.SyntheticagonistsofLXRs are potent stimulators of fatty acid synthesis, which ismediated largely by sterol regulatory element-binding pro-tein-1c (SREBP-1c). Paradoxically, an improved hepatic lipidprofilebyLXRwasobservedinmicefedaWesternhighfat(HF)diet. To explore the underlying mechanism, we administeredmicenormalchoworanHFdietandoverexpressedLXR intheliver.TheHFdietwithtail-veininjectionofadenovirusofLXRincreasedtheexpressionofLXR-targetedgenesinvolvedincho-lesterol reverse transport but not …

Expression profiling of hepatic genes associated with lipid metabolism in nephrotic rats

Yunfeng Zhou, Xiaoyan Zhang, Lihong Chen, Jing Wu et autres

Hyperlipidemia is one of the major features of nephrotic syndrome (NS). Although many factors have been implicated in the pathogenesis of NS-related dyslipidemia, the underlying mechanisms remain largely uncharacterized. The present study was designed to examine the gene profile associated with lipid …

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ATF6 up--regulates ABCA1 expression

Hongling Li, Minjia Zhu, Huaixin Dang, 汪保国 et autres

ATP-binding cassette transporter A1 (ABCA1) is an important membrane transporter for cholesterol and lipids, it promotes overloaded cholesterol to efflux from cells to ApoA-I and package into high-density lipoprotein, which process involved in revise cholesterol transfer. In this study, we found the …

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