Yubo He

Leukocyte immunoglobulin-like receptor A3 inhibits the activity of immunosuppressive myeloid cells

Meng Fang, Xing Yang, Jingjing Xie, Qi Lou et autres

Myeloid checkpoint blockade as monotherapy often yields limited benefit, suggesting that multiple inhibitory pathways cooperatively sustain myeloid immunosuppression in the tumor microenvironment (TME). However, strategies to concurrently target multiple myeloid checkpoints remain challenging. Leukocyte immunoglobulin-like receptor A3 (LILRA3) is a soluble LILRA/B …

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Mechanical Regulation of the Immune System: From Sensory Mechanisms to Disease Pathogenesis

Yubo He, M K Zhang, Sheng Xia

BACKGROUND: Biochemical signals have long dominated immunology, but mechanical force is now recognized as a fundamental regulator of immune cell behavior. Immune cells sense core mechanical cues via specialized mechanosensors, and dysregulated tissue mechanics in inflammation, fibrosis and tumors disrupt normal immunity. …

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Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer

Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie et autres

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 …

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Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors

Chengcheng Zhang, Yubo He, Jingjing Xie, Qi Lou et autres

Amyloid proteins are linked to various diseases; however, their functional roles in immunity and cancer remain unclear. Here, we establish a direct link between oligomeric cystatin C-a cysteine cathepsin inhibitor and a well-characterized amyloidogenic protein-within the tumor microenvironment and the immune inhibitory …

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Machine learning-based construction of Immunogenic cell death-related score for improving prognosis and personalized treatment in glioma

Guoyin Li, Yubo He, Zhengzi Qian, Yiwen Liu et autres

Immunogenic cell death (ICD) is capable of activating both innate and adaptive immune responses. In this study, we aimed to develop an ICD-related signature in glioma patients and facilitate the assessment of their prognosis and drug sensitivity. Consensus clustering and non-negative matrix …

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Secretogranin 2 binds LILRB4 resulting in immunosuppression

Ryan Yuki Huang, Meng Fang, Yubo He, Jingjing Xie et autres

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Data from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Abstract Immunosuppressive myeloid cells are critical obstacles to T cell–centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. …

Figure S6 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S6. EphB1 expression on tumor cells promotes T cell exhaustion in LILRB5 transgenic mice.

Figure S1 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S1. Eph receptors do not bind to LILRB1, LILRB3, LILRB4 and LAIR1.

Supplementary Tables 1-5 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Supplementary Tables S1-S5

Figure S2 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S2. LILRB5-ECD induces EphB1 phosphorylation.

Figure S3 from Eph Receptors Activate Myeloid Checkpoint Receptor LILRB5 to Support Tumor Development

Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng et autres

Fig. S3. EphB1 activates LILRB5 in vitro and promote immune suppressive functions.