Weina Shang

MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair

Nuo Chen, Zhirong Li, Xiyuan Wang, Hong Xu et autres

Mitochondria are continuously exposed to damage that contributes to aging and disease. While prolongedly damaged mitochondria are eliminated by mitophagy, how cells respond to transient damage remains unclear. Here, we establish a cell-based system to induce transient mitochondrial stress and resolve its …

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A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand

Z Li, Nuo Chen, Caixia Zhou, Lingna Xu et autres

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Mitochondrial proteases maintain cellular protein homeostasis and tissue integrity

Kexin Shi, Hao Liu, H Xu, Weina Shang et autres

BACKGROUND: Mitochondrial proteases are essential for mitochondrial protein import and constitute the core of the organelle's intrinsic protein quality control system. However, their physiological functions across tissues, as well as their influence on cytosolic proteostasis, remain incompletely understood. RESULTS: We generated loss- …

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Drosophila Myc ameliorates defects in mitochondrial homeostasis and muscle maturation caused by Metaxin-2 deficiency

Xinyi Shou, Xiaoyu Fan, Ling Li, Yina Ruan et autres

Mitochondrial protein import machineries are essential for organelle homeostasis. Metaxin-2 (Mtx2) is an evolutionarily conserved component of the mitochondrial sorting and assembly machinery, and its mutations are associated with a progeroid syndrome, named mandibuloacral dysplasia associated to Mtx2 (MADaM). To investigate the …

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Doctor-child communication and caregivers’ willingness to recommend hospital: a secondary analysis using pediatric patient experience data

Hao Huang, Weina Shang, Ming Zhu, Guangyu Hu

Background: Doctor-child communication is central to pediatric care, yet current research often marginalizes child-centered interactions and fails to isolate which specific behaviors drive systemic hospital metrics. This study addresses these gaps by using The Child Hospital Consumer Assessment of Healthcare Providers and …

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Microscopic probing into plasmodesmata (PD) and PD-derived intercellular gateways (PdIGs): Beyond morphology

Ming-Fang Lv, Weina Shang, Yuanxing Dai, Junying Li et autres

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Mitochondrial protein nmd regulates lipophagy and general autophagy during development

Wei Wang, Xufeng Wang, Xiaoqi Zhou, Lu Jiang et autres

Lipophagy engulfs lipid droplets and delivers them to lysosomes for degradation. We found that lipophagy levels were low in most fly tissues, except for the prothoracic gland (PG) during larval development. Therefore, we performed a small-scale screening in the PG to identify …

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Drosophila Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashion

Xinyi Shou, Ling Li, Wei Li, Weina Shang et autres

Abstract Metaxin-2 (Mtx2) is an evolutionarily conserved mitochondrial outer membrane protein. Mutations in human Mtx2 cause mandibuloacral dysplasia (MADaM), a progeroid disorder. However, the pathologic mechanisms of Mtx2 loss-of-function remain largely unknown. Using Drosophila , we show Mtx2 null mutants exhibit pupal …

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Ectopic protein lysine methacrylation contributes to defects caused by loss of HIBCH or ECHS1

Yawen Li, Ting Wu, Yaoyao Li, Chaolong Xu et autres

The absence of HIBCH or ECHS1, two Leigh syndrome genes, in cultured cells results in abnormal mitochondrial morphology and respiratory defects. Fly eyes lacking either protein exhibit age-dependent degeneration. Elevated lysine methacrylation (Kmea) is observed in both HIBCH- and ECHS1-deficient cells and …

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TRABD modulates mitochondrial homeostasis and tissue integrity

Caixia Zhou, Zhirong Li, Yawen Li, Yaoyao Li et autres

High TRABD expression is associated with tau pathology in patients with Alzheimer's disease; however, the function of TRABD is unknown. Human TRABD encodes a mitochondrial outer-membrane protein. The loss of TRABD resulted in mitochondrial fragmentation, and TRABD overexpression led to mitochondrial clustering …

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Volume electron microscopy reconstruction uncovers a physical barrier that limits virus to phloem

Ming-Fang Lv, Yuanxing Dai, Li Xie, Jiansheng Guo et autres

Most plant reoviruses are phloem-limited, but the mechanism has remained unknown for more than half a century. Southern rice black-streaked dwarf virus (Fijivirus, Reoviridae) causes phloem-derived tumors, where its virions, genomes, and proteins accumulate, and it was used as a model to …

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PtdIns4P exchange at endoplasmic reticulum-autolysosome contacts is essential for autophagy and neuronal homeostasis

Hao Liu, Wenxia Shao, Wei Liu, Weina Shang et autres

Inter-organelle contacts enable crosstalk among organelles, facilitating the exchange of materials and coordination of cellular events. In this study, we demonstrated that, upon starvation, autolysosomes recruit Pi4KIIα (Phosphatidylinositol 4-kinase II α) to generate phosphatidylinositol−4-phosphate (PtdIns4P) on their surface and establish endoplasmic reticulum …

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