Nuo Chen

Imbalance of the CaSR-SIRT3 axis exacerbates ventricular remodeling by promoting macrophage M1 polarization via the AMPK signaling pathway post-myocardial infarction

Linlin Song, Qipei Liu, Nuo Chen, Xue Sun et autres

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Opposite-signal ratiometric PEC-EC aptasensor with cascade amplification and self-calibration for reliable TNF-α detection

Qinwei ZHAO, Yuhang Su, Ying Tang, Xing Tang et autres

cn (code pays fourni par la source)

MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair

Nuo Chen, Zhirong Li, Xiyuan Wang, Hong Xu et autres

Mitochondria are continuously exposed to damage that contributes to aging and disease. While prolongedly damaged mitochondria are eliminated by mitophagy, how cells respond to transient damage remains unclear. Here, we establish a cell-based system to induce transient mitochondrial stress and resolve its …

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Lycopene alleviates zearalenone-induced testicular damage in chickens by inhibiting oxidative stress, necroptosis, and inflammation

Qingyu Yang, Shu Wang, Nuo Chen, He Wu et autres

Abstract Zearalenone (ZEN) is a common mycotoxin that can cause toxic damage to the testes of male animals. Although existing studies have demonstrated that lycopene (LYC) can antagonize the toxicity of zearalenone (ZEN), how LYC alleviates ZEN-induced testicular damage in chickens by …

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Integrating multi-algorithm data-driven empirical modeling to unravel structure–antioxidant relationships of medicinal plant polysaccharides

Caijing Yang, Nuo Chen, Mengru Yao, Tong Li et autres

Oxidative stress contributes to the pathogenesis of numerous diseases, and medicinal plant polysaccharides (MPPs) are promising natural antioxidants. However, the substantial structural heterogeneity of MPPs complicates the establishment of reliable structure–activity relationships, thereby limiting their rational screening and development. This study aimed …

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Design and evaluation of pectin-based nanoparticles for overcoming biological barriers as insulin carriers with oral administration potential

Nuo Chen, Xijia Zhang, Weichao Cao, Hong Tian et autres

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Single-Electrode COF-Based Multiplex Photoelectrochemical Biosensor with Combinatorial DNA Logic Gate for Intelligent Discrimination of Inflammatory Biomarkers

Yuhang Su, Qinwei ZHAO, Ying Tang, Nuo Chen et autres

Simultaneous and accurate detection of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) is critical for the early diagnosis and monitoring of inflammatory diseases. However, conventional analytical methods are often cumbersome, time-consuming, and limited in the capacity for simultaneous multiplex analysis and rapid …

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New perspectives on serum-free cell culture: Harnessing microbial resources for innovative media development in food biomanufacturing

Qinya Niu, Nuo Chen, Qinghua Ye, Qingping Wu et autres

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Designing Fidelity of CRISPR-Cas Endonucleases by Kinetic Insights

Huihui Liu, Z Hong Zhou, Luowei Yuan, Bin Pang et autres

Finding high-fidelity CRISPR-Cas variants is critical for both the precision of in vitro DNA detection and the safety of in vivo gene-editing therapeutics. However, the large size of the Cas enzyme and the distinct selection criteria between its natural evolution and clinical …

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Metal–Organic Framework as a Bioorthogonal Catalyst for Gene Editing

Z H Chen, Xingyu Liu, Wanyue Sang, Li Li et autres

We report the use of reticular design to construct metal-organic frameworks (MOFs) with molecularly defined catalytic pores for bioorthogonal RNA manipulation in living cells. A library of crystalline MOFs with systematically varied Cu cluster geometries, pore dimensions, and chemical environments was assembled …

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Fluid flow engineering in slot channel and shearing meniscus enables balanced crystallinity and efficient air-processed organic solar cells

Zhaozhao Bi, Zilu Liu, Yanni Ouyang, Dongjie Liu et autres

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Glycogen metabolic dysfunction in T2DM with MASLD: linking α-hydroxybutyrate to GYS2 downregulation

Zichen Zhang, Nuo Chen, Xiaojing Yuan, Jie Li et autres

Objective This study aimed to investigate the molecular characteristics of T2DM with MASLD in a C57 mouse model, using multi-omics techniques to identify key nutritional metabolites that drive metabolic dysfunction. The goal was to reveal how metabolic disturbances are linked to transcriptional …

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