MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair
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Le résumé fourni par la source
Mitochondria are continuously exposed to damage that contributes to aging and disease. While prolongedly damaged mitochondria are eliminated by mitophagy, how cells respond to transient damage remains unclear. Here, we establish a cell-based system to induce transient mitochondrial stress and resolve its recovery dynamics. We identify the E3 ubiquitin ligase mahogunin ring finger 1 (MGRN1) as a damage-threshold sensor that discriminates between transient and prolonged mitochondrial insults. Under transient stress, MGRN1 shows enhanced association with the outer mitochondrial membrane via MFN1, where it restrains mitophagy, potentially preserving mitochondria for repair. Loss of MGRN1 disrupts this checkpoint, leading to inappropriate mitophagy and impaired recovery. Mechanistically, mitochondrial repair is coordinated by the DELE1-eIF2α-ATF4 axis, Nrf2 signaling, and JUN/FOS activation, which collectively drive an antioxidant program, with TXNRD1 and SLC7A11 as downstream effectors. Together, our findings uncover a damage-sensing checkpoint that gates the decision between recovery and clearance, and reveal active and regulated pathways for mitochondrial repair.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- MGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Zhejiang University MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
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School of Medicine Department of Obstetrics and Gynecology of the Second Affiliated Hospital pays non établi dans la noticeUniversité ou école supérieure
MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network — Zhejiang University, Second Affiliated Hospital of Zhejiang University et Department of Obstetrics and Gynecology of the Second Affiliated Hospital — School of Medicine.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.