Honggen Wang

Photoredox/Nickel-Catalyzed Decarboxylative Monofluoromethylation of β-Boryl NHPI Esters via Radical 1,2-Boron Migration

Shuang Lin, Yifan Yang, Qingjiang Li, Shi‐Liang Huang et autres

A photoredox/nickel dual-catalyzed decarboxylative monofluoromethylation of β-boryl NHPI esters has been developed. The reaction proceeds through a radical 1,2-boron shift cascade, enabling the efficient conversion of β-boryl radicals into carbon radicals for subsequent SH2 cross-coupling with a monofluoromethyl radical. This method provides …

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Direct copper-catalysed deaminative cyanation of aliphatic primary amines

Jiang‐Hao Xue, Shuang Lin, J Huang, Taeseok Kang et autres

The cyano group is a versatile motif in medicinal chemistry, serving as both a target and a precursor to other functional groups. However, direct deaminative cyanation of aliphatic amines remains a challenge due to the inertness of C–N bonds and the instability …

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Direct Deaminative Alkynylation of Aliphatic Primary Amines

Jia-Luo Fu, Jun‐Yunzi Wu, Qi Fan, Jiang‐Hao Xue et autres

ABSTRACT Alkyl‐substituted internal alkynes are useful motifs in organic synthesis and medicinal chemistry, but their preparation from common amine precursors remains challenging. Aliphatic primary amines are widespread functional groups, yet their direct use as alkylating reagents is limited by the strength of …

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Direct Deaminative Alkynylation of Aliphatic Primary Amines

Jia-Luo Fu, Jun‐Yunzi Wu, Qi Fan, Jiang‐Hao Xue et autres

ABSTRACT Alkyl‐substituted internal alkynes are useful motifs in organic synthesis and medicinal chemistry, but their preparation from common amine precursors remains challenging. Aliphatic primary amines are widespread functional groups, yet their direct use as alkylating reagents is limited by the strength of …

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Synthesis of N-trifluoromethyl indoles via a modified fluorinative Fukuyama-type cyclization of o-alkenyl arylisocyanides

Jun‐Yunzi Wu, Jia-Luo Fu, Shuang Lin, Haichao Liu et autres

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β-Boron or β-silicon effect enables a regioselective Ni-catalyzed hydrocyanation of internal alkynes

Zhi-Hao Chen, Shuang Lin, Xinman Kang, Jiawu Huang et autres

An Earth-abundant nickel-catalysed regioselective hydrocyanation of propargylic B(MIDA) or silane substrates with AIBN (2,2′-azobis(2-methylpropionitrile)) as a low-toxicity H–CN source is reported.

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Regio‐Divergent and Stereo‐Controlled Alder‐Ene Reaction: Harnessing the Unique Electronic and Steric Properties of B(MIDA) Moiety

Jiawu Huang, Bo-Wen Xiao, Wenjin Zhang, Qingjiang Li et autres

Abstract 1,4‐Dienes are pivotal structural motifs in bioactive natural products and serve as valuable intermediates in synthetic chemistry. Among the various methods for their synthesis, the ruthenium‐catalyzed Alder‐ene reaction stands out due to its redox‐neutral, atom‐ and step‐efficient nature. However, controlling regioselectivity …

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Regio‐Divergent and Stereo‐Controlled Alder‐Ene Reaction: Harnessing the Unique Electronic and Steric Properties of B(MIDA) Moiety

Jiawu Huang, Bo-Wen Xiao, Wenjin Zhang, Qingjiang Li et autres

1,4-Dienes are pivotal structural motifs in bioactive natural products and serve as valuable intermediates in synthetic chemistry. Among the various methods for their synthesis, the ruthenium-catalyzed Alder-ene reaction stands out due to its redox-neutral, atom- and step-efficient nature. However, controlling regioselectivity with …

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Direct Catalytic Deaminative Cyanation of Aliphatic Primary Amines

Jiang‐Hao Xue, Shuang Lin, Jiawu Huang, Taeseok Kang et autres

The cyano group is an important and versatile functional group in medicinal chemistry. It is an important target in its own right while also serving as a precursor to other valuable motifs including aminomethyl and carboxamide groups. However, direct deaminative cyanation of …

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Development of Indolo‐Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes

Yuan Liu, Jun‐Yunzi Wu, Shuang Lin, Fan Qi et autres

Semisaturated ring systems with a balanced fraction of C(sp3) have garnered increasing attention in drug development. In this study, we propose indolo-bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for synthesizing this new semisaturated polycyclic scaffold. The synthesis involves …

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Development of Indolo‐Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes

Yuan Liu, Jun‐Yunzi Wu, Shuang Lin, Fan Qi et autres

Abstract Semisaturated ring systems with a balanced fraction of C(sp3) have garnered increasing attention in drug development. In this study, we propose indolo‐bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for synthesizing this new semisaturated polycyclic scaffold. The synthesis …

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Selective Synthesis of Z-α-Iodostyrenes via Hydroiodination and Photochemical Manganese-Catalyzed Geometric Isomerization

Ya‐Jie Tang, Qi Fan, Shuang Lin, Qingjiang Li et autres

Alkenyl iodides are essential intermediates in organic synthesis, traditionally synthesized via hydrometalation of alkynes or direct hydroiodination, which favor the formation of E isomers. However, methods for selectively producing Z -isomers remain underdeveloped. Inspired by photoinduced manganese-mediated iodine abstraction and radical rebound …

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