Shuang Lin

β-Boron or β-silicon effect enables a regioselective Ni-catalyzed hydrocyanation of internal alkynes

Zhi-Hao Chen, Shuang Lin, Xinman Kang, Jiawu Huang et autres

An Earth-abundant nickel-catalysed regioselective hydrocyanation of propargylic B(MIDA) or silane substrates with AIBN (2,2′-azobis(2-methylpropionitrile)) as a low-toxicity H–CN source is reported.

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Direct Catalytic Deaminative Cyanation of Aliphatic Primary Amines

Jiang‐Hao Xue, Shuang Lin, Jiawu Huang, Taeseok Kang et autres

The cyano group is an important and versatile functional group in medicinal chemistry. It is an important target in its own right while also serving as a precursor to other valuable motifs including aminomethyl and carboxamide groups. However, direct deaminative cyanation of …

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Development of Indolo‐Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes

Yuan Liu, Jun‐Yunzi Wu, Shuang Lin, Fan Qi et autres

Semisaturated ring systems with a balanced fraction of C(sp3) have garnered increasing attention in drug development. In this study, we propose indolo-bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for synthesizing this new semisaturated polycyclic scaffold. The synthesis involves …

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Development of Indolo‐Bicyclo[3.1.1]Heptane as a Carbazole Isostere Through Radical Indolization of Bicyclo[1.1.0]Butanes

Yuan Liu, Jun‐Yunzi Wu, Shuang Lin, Fan Qi et autres

Abstract Semisaturated ring systems with a balanced fraction of C(sp3) have garnered increasing attention in drug development. In this study, we propose indolo‐bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for synthesizing this new semisaturated polycyclic scaffold. The synthesis …

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Selective Synthesis of Z-α-Iodostyrenes via Hydroiodination and Photochemical Manganese-Catalyzed Geometric Isomerization

Ya‐Jie Tang, Qi Fan, Shuang Lin, Qingjiang Li et autres

Alkenyl iodides are essential intermediates in organic synthesis, traditionally synthesized via hydrometalation of alkynes or direct hydroiodination, which favor the formation of E isomers. However, methods for selectively producing Z -isomers remain underdeveloped. Inspired by photoinduced manganese-mediated iodine abstraction and radical rebound …

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Harnessing the β-boron effect for regioselective Ru-catalyzed hydrosilylation of internal alkynes

Jiasheng Qian, Shuang Lin, Zhihao Chen, Jiawu Huang et autres

Metal-catalyzed hydrosilylation of alkynes is recognized as a straightforward and atom economic method for synthesizing alkenylsilanes. While substantial advancements have been made with terminal alkynes, achieving precise regio- and stereocontrol with unsymmetrical internal alkynes remains a significant challenge. In this study, we …

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Development of Indolo-Bicyclo[3.1.1]heptane as a Carbazole Isostere through Radical Indolization of Bicyclo[1.1.0]butanes

Honggen Wang, Yuan Liu, Jun‐Yunzi Wu, Fan Qi et autres

Semisaturated ring systems with a balanced fraction of Csp3 have garnered increasing attention in drug development. In this study, we propose indolo-bicyclo[3.1.1]heptane as a potential carbazole isostere and present a novel strategy for synthesizing this new semisaturated polycyclic scaffold. The synthesis involves …

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Saturated F 2 ‐Rings from Alkenes

Li Yin, Vadym Sham, Ivan G. Logvinenko, Shuang Lin et autres

Abstract A general method to convert simple exocyclic alkenes into saturated F 2 ‐rings has been developed. The reaction involves reagent C 6 F 5 I(OAc) 2 . The reaction efficiently works on the mg‐, g‐, and even multigram scale.

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Saturated F 2 ‐Rings from Alkenes

Li Yin, Vadym Sham, Ivan G. Logvinenko, Shuang Lin et autres

Abstract A general method to convert simple exocyclic alkenes into saturated F 2 ‐rings has been developed. The reaction involves reagent C 6 F 5 I(OAc) 2 . The reaction efficiently works on the mg‐, g‐, and even multigram scale.

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Saturated F2-rings from Alkenes

Honggen Wang, Li Yin, Xiaobin Liu, Vadym Sham et autres

A general method to convert simple exocyclic alkenes (no Ar-substituents) into saturated F2-rings has been developed. The reaction involves the IIII-reagent C6F5I(OAc)2 (F5-PIDA). The reaction efficiently works on a mg-, g-, and even multigram scale.

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Pyridine-boryl radical-catalyzed [3π + 2σ] cycloaddition for the synthesis of pyridine isosteres

Yuan Liu, Shuang Lin, Zhengwei Ding, Yin Li et autres

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β-Silicon Effect Enables Metal-Free Site-Selective Intermolecular Allylic C–H Amination

Shuang Lin, Yuan Liu, Gao Kun-yu, Zhihao Chen et autres

α-Amino silanes and their derivatives play pivotal roles across diverse applications, yet their current synthetic methods often entail intricate functional group manipulations. Despite the widespread use of allyl silanes as carbon nucleophiles in organic synthesis, their participation in allylic C–H functionalization has …

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