Juho Vuononvirta

Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina et autres

In the version of this article initially published, due to a production processing error, the lower graphs in Fig. 1a, b, now labelled “CD4 + ,” appeared originally as “CD8 + .” The figure has been amended in the HTML and PDF …

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The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina et autres

Abstract T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the glycolytic pathway are major checkpoints for this event. Here …

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Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators.

Maryam Jangani, Juho Vuononvirta, Lamya Zohair Yamani, Eleanor Jayne Ward et autres

Monocyte migration to the sites of inflammation and maturation into macrophages are key steps for their immune effector function. Here, we show that mechanistic target of rapamycin complex 2 (mTORC2)-dependent Akt activation is instrumental for metabolic reprogramming at the early stages of …

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Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou et autres

Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare …

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Maturation, developmental site, and pathology dictate murine neutrophil function

John B. G. Mackey, Amanda J. McFarlane, Thomas J. Jamieson, René Jackstadt et autres

Abstract Neutrophils have been implicated in poor outcomes in cancer and severe inflammation. We found that neutrophils expressing intermediate levels of Ly6G (Ly6G Int ) were present in mouse cancer models and more abundant in those with high rates of spontaneous metastasis. …

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Lung Marginated and Splenic Murine Resident Neutrophils Constitute Pioneers in Tissue-Defense During Systemic E. coli Challenge

Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi et autres

The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights into the molecular …

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Metabolic regulation of T lymphocyte motility and migration

Juho Vuononvirta, Federica M. Marelli‐Berg, Thanushiyan Poobalasingam

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Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming

Kenneth Chat-Pan Cheung, Silvia Fanti, Claudio Mauro, Guosu Wang et autres

Endothelial barrier (EB) breaching is a frequent event during inflammation, and it is followed by the rapid recovery of microvascular integrity. The molecular mechanisms of EB recovery are poorly understood. Triggering of MHC molecules by migrating T-cells is a minimal signal capable …

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TLR4 Polymorphism, Nasopharyngeal Bacterial Colonization, and the Development of Childhood Asthma: A Prospective Birth-Cohort Study in Finnish Children

Johanna T. Teräsjärvi, Laura Toivonen, Juho Vuononvirta, Jussi Mertsola et autres

We aimed to explore the role of TLR4 (rs4986790) polymorphism in the nasopharyngeal (NP) bacterial colonization and its consequent impact on the development of childhood asthma. A semi-quantitative culture of NP swabs was performed on 473 children at 2 months of age …

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Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte–dendritic cell antigen presentation

Dhiren F. Patel, Teresa Peiró, Nicoletta Bruno, Juho Vuononvirta et autres

G-CSF augments T H 2 responses in allergen-sensitized mice and is negatively regulated by transmigrated lung neutrophils.

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Pulmonary natural killer cells control neutrophil intravascular motility and response to acute inflammation

Judith Secklehner, Katia De Filippo, John B. G. Mackey, Juho Vuononvirta et autres

Abstract The pulmonary immune system defends a huge surface area directly in contact with the contents of the air we breathe. Neutrophils, the most abundant immune cell in the pulmonary vasculature, are critical to immunity but they are also capable of generating …

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Pulmonary environmental cues drive group 2 innate lymphoid cell dynamics in mice and humans

Franz K Puttur, Laura Denney, Lisa G. Gregory, Juho Vuononvirta et autres

Group 2 innate lymphoid cells (ILC2s) are enriched in mucosal tissues (e.g., lung) and respond to epithelial cell-derived cytokines initiating type 2 inflammation. During inflammation, ILC2 numbers are increased in the lung. However, the mechanisms controlling ILC2 trafficking and motility within inflamed …

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