Silvia Fanti

Dysregulated T Cell–Mediated Immunity Underlies Progression of Arrhythmogenic Right Ventricular Cardiomyopathy

Alexandros Protonotarios, Silvia Fanti, Barbara Szomolay, Imogen Heenan et autres

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Combined Adaptive Immune Mechanisms Mediate Cardiac Injury After COVID-19 Vaccination

Silvia Fanti, Carlene Dyer, Inga Jóna Ingimarsdóttir, Daniel Harding et autres

BACKGROUND: The COVID-19 pandemic, caused by SARS-CoV-2, has led to the first approval of mRNA vaccines in humans. By producing the full-length SARS-CoV-2 Spike protein, they induce protective antiviral immunity. Acute myopericarditis (AMP) development after vaccination has repeatedly been reported; however, the …

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Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina et autres

In the version of this article initially published, due to a production processing error, the lower graphs in Fig. 1a, b, now labelled “CD4 + ,” appeared originally as “CD8 + .” The figure has been amended in the HTML and PDF …

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Cytotoxic T Cells Drive Outcome in Inflammatory Dilated Cardiomyopathy

Maurits A. Sikking, Daniel Harding, Michiel T.H.M. Henkens, Sophie L.V.M. Stroeks et autres

sponsorship: The authors acknowledge the Double Dose Program 2020-B005, CVONAr-ena-PRIME-2017-18, HORIZON-EIC-2022-PATHFINDERCHALLENGES, ZonMW-Metacor, and British Heart Foundation grants FS/CRTF/20/24058, RG/20/8/34995, CH/15/2/32064, and AA/18/5/34222. (HORIZON-EIC-2022-PATHFINDERCHALLENGES|2020-B005, ZonMW-Metacor, British Heart Foundation|FS/CRTF/20/24058, British Heart Foundation|RG/20/8/34995, British Heart Foundation|CH/15/2/32064, British Heart Foundation|AA/18/5/34222)

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Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation

Vishal Vyas, Balraj Sandhar, Jack M. Keane, Elizabeth G. Wood et autres

Abstract Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk of stroke and heart failure. Here we investigated how the immune infiltrate of human epicardial adipose tissue (EAT), which directly overlies the myocardium, contributes to AF. Flow …

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Erratum to “CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis” [Pharmacol. Res. 207 (2024) 107346]

Kenneth Cheung, Jiao Ma, Lu Wang, Xingxuan Chen et autres

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CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis

Kenneth Cheung, Jiao Ma, Lu Wang, Xingxuan Chen et autres

Synovitis is characterized by a distinctmetabolic profile featuring the accumulation of lactate, a byproduct of cellular metabolism within inflamed joints. This study reveals that the activation of the CD31 signal by lactate instigates a metabolic shift, specifically initiating endothelial cell autophagy. This …

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Innate and adaptive immunity in acute myocarditis

Michele Golino, Daniel Harding, Marco Giuseppe Del Buono, Silvia Fanti et autres

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The Hepatocyte Growth Factor/Cmet Axis in Autoimmune Cardiac Inflammation and Beyond

Silvia Fanti, Daniel Harding, Federica M. Marelli‐Berg

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Tumour necrosis factor-α in cardiac inflammation: friend or foe?

Daniel Harding, Silvia Fanti, Federica M. Marelli‐Berg

This editorial refers to ‘TNF-α protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4+ T cells’, by F. Rolski et al., https://doi.org/10.1093/cvr/cvad158. The pathological role of tumour necrosis factor-α (TNF-α) in acute and chronic human cardiovascular disease …

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Tissue-resident memory T cells in Epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in Atrial Fibrillation

M. Paula Longhi, Vishal Vyas, Balraj Sandhar, Elizabeth G. Wood et autres

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The glucose transporter 2 regulates CD8+ T cell function via environment sensing

Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina et autres

Abstract T cell activation is associated with a profound and rapid metabolic response to meet increased energy demands for cell division, differentiation and development of effector function. Glucose uptake and engagement of the glycolytic pathway are major checkpoints for this event. Here …

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