Loredana Guglielmi

Challenges and Innovations in Paediatric Brain Tumour Treatments

Jessica Sohl, Massimo Ganassi, Loredana Guglielmi, Sara Badodi

Paediatric brain tumours are the most common solid tumours and the leading cause of cancer-related mortality in children. Current treatment, which includes surgery, chemotherapy, and radiotherapy, has improved survival for some types of them but is associated with significant long-term side effects …

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Lamin A/C regulates cerebellar granule cell maturation

Laura Vilardo, Ingrid Cifola, Marta Nardella, Paride Pelucchi et autres

Lamin A/C is a nuclear type V intermediate filament protein part of the meshwork structure underlying the inner nuclear membrane (nuclear lamina), which plays numerous roles, including maintenance of nuclear shape, heterochromatin organization, and transcriptional regulation. Our group has demonstrated the role …

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Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

James R. Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel et autres

We describe a subset of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the identification of enriched …

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Author response: Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

James R. Boot, Gabriel Rosser, Dailya Kancheva, Claire Vinel et autres

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Global hypo-methylation in a subgroup of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape

James R. Boot, Gabriel Rosser, Daliya Kancheva, Claire Vinel et autres

Abstract We describe a new molecular subgroup of glioblastoma, the most prevalent malignant adult brain tumour, harbouring a bias towards hypomethylation at defined differentially methylated regions. This epigenetic signature correlates with an enrichment for an astrocytic gene signature, which together with the …

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Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma

Claire Vinel, Gabriel Rosser, Loredana Guglielmi, Myrianni Constantinou et autres

Epigenetic mechanisms which play an essential role in normal developmental processes, such as self-renewal and fate specification of neural stem cells (NSC) are also responsible for some of the changes in the glioblastoma (GBM) genome. Here we develop a strategy to compare …

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Role of Lamin A/C as Candidate Biomarker of Aggressiveness and Tumorigenicity in Glioblastoma Multiforme

Giuliana Gatti, Laura Vilardo, Carla Musa, Chiara Di Pietro et autres

Nuclear lamina components have long been regarded as scaffolding proteins, forming a dense fibrillar structure necessary for the maintenance of the nucleus shape in all the animal kingdom. More recently, mutations, aberrant localisation and deregulation of these proteins have been linked to …

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Microglia promote glioblastoma via mTOR‐mediated immunosuppression of the tumour microenvironment

Anaelle Aurelie Dumas, Nicola Pomella, Gabriel Rosser, Loredana Guglielmi et autres

Tumour-associated microglia/macrophages (TAM) are the most numerous non-neoplastic populations in the tumour microenvironment in glioblastoma multiforme (GBM), the most common malignant brain tumour in adulthood. The mTOR pathway, an important regulator of cell survival/proliferation, is upregulated in GBM, but little is known …

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Circulating miRNAs in Small Extracellular Vesicles Secreted by a Human Melanoma Xenograft in Mouse Brains

Loredana Guglielmi, Marta Nardella, Carla Musa, Ingrid Cifola et autres

The identification of liquid biomarkers remains a major challenge to improve the diagnosis of melanoma patients with brain metastases. Circulating miRNAs packaged into tumor-secreted small extracellular vesicles (sEVs) contribute to tumor progression. To investigate the release of tumor-secreted miRNAs by brain metastasis, …

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Polycomb-mediated repression of EphrinA5 promotes growth and invasion of glioblastoma

Barbara Ricci, Thomas O Millner, Nicola Pomella, Xinyu Zhang et autres

Glioblastoma (GBM) is the most common and most aggressive intrinsic brain tumour in adults. Integrated transcriptomic and epigenomic analyses of glioblastoma initiating cells (GIC) in a mouse model uncovered a novel epigenetic regulation of EfnA5. In this model, Bmi1 enhances H3K27me3 at …

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Establishment and Culture of Patient-Derived Primary Medulloblastoma Cell Lines

Sara Badodi, Silvia Marino, Loredana Guglielmi

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THREE-DIMENSIONAL MULTICOLOUR LINEAGE TRACING OF INTRINSIC BRAIN TUMOUR MODELS

James Innes, Tian Yu, Loredana Guglielmi, Sebastian Brandner

Multicolour lineage tracing has provided striking demonstrations of stem cell tissue maintenance and development. Our objective is to gain insight into histogenesis, clonal expansion and migration of intrinsic brain tumours. We aim to investigate intratumoral heterogeneity through the identification of differently labelled …