Accès ouvert
2021
preprint
OpenAlex
John B. G. Mackey, Amanda J. McFarlane, Thomas J. Jamieson, René Jackstadt et autres
Abstract Neutrophils have been implicated in poor outcomes in cancer and severe inflammation. We found that neutrophils expressing intermediate levels of Ly6G (Ly6G Int ) were present in mouse cancer models and more abundant in those with high rates of spontaneous metastasis. …
gb, de
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Accès ouvert
2021
article
OpenAlex
Astrid Sissel Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg et autres
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however, it did not appear as effective for …
dk, gb, si, no
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Accès ouvert
2021
article
OpenAlex
Goda Juzenaite, Judith Secklehner, Juho Vuononvirta, Yoseph Helbawi et autres
The rapid response of neutrophils throughout the body to a systemic challenge is a critical first step in resolution of bacterial infection such as Escherichia coli (E. coli). Here we delineated the dynamics of this response, revealing novel insights into the molecular …
gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Katia De Filippo, Sara M. Rankin
Neutrophils are the most abundant circulating leukocyte within the blood stream and for many years the dogma has been that these cells migrate rapidly into tissues in response to injury or infection, forming the first line of host defense. While it has …
gb
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Janesh Pillay, Nicola Tregay, Goda Juzenaite, Leo M. Carlin et autres
Treatment with the CXCR4 antagonist, plerixafor (AMD3100), has been proposed for clinical use in patients with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome and in pulmonary fibrosis. However, there is controversy with respect to the impact of plerixafor on neutrophil dynamics in …
nl, gb
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Accès ouvert
2019
preprint
OpenAlex
Judith Secklehner, Katia De Filippo, John B. G. Mackey, Juho Vuononvirta et autres
Abstract The pulmonary immune system defends a huge surface area directly in contact with the contents of the air we breathe. Neutrophils, the most abundant immune cell in the pulmonary vasculature, are critical to immunity but they are also capable of generating …
gb, us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Katia De Filippo, Sara M. Rankin
BACKGROUND: Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. RESULTS: The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. CONCLUSION: In this review, we focus on the role …
gb
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Accès ouvert
2017
article
OpenAlex
Delfim Duarte, Edwin D. Hawkins, Olufolake Akinduro, Heather Yin-Kuan Ang et autres
Bone marrow vascular niches sustain hematopoietic stem cells (HSCs) and are drastically remodeled in leukemia to support pathological functions. Acute myeloid leukemia (AML) cells produce angiogenic factors, which likely contribute to this remodeling, but anti-angiogenic therapies do not improve AML patient outcomes. …
gb, au, ie, de, us
(code pays fourni par la source)
2014
article
OpenAlex
Katia De Filippo, Daniel R. Neill, Meg Mathies, Mathieu Bangert et autres
The S100A8/A9 heterodimer is abundantly expressed by myeloid cells, especially neutrophils, but its mechanism of action is only partially determined. In this study we investigated S100A8/A9 involvement in the host response to Streptococcus pneumoniae infection making use of S100a9(-/-) mice that lack …
gb
(code pays fourni par la source)
2013
article
OpenAlex
Katia De Filippo, Anne Dudeck, Mike Hasenberg, Emma L. Nye et autres
Neutrophil recruitment is an important early step in controlling tissue infections or injury. Here, we report that this influx depends on both tissue-resident mast cells and macrophages. Mice with mast cell deficiency recruit reduced numbers of neutrophils in the first few hours …
gb, de, nl
(code pays fourni par la source)
2011
article
OpenAlex
Aras Kadioglu, Katia De Filippo, Mathieu Bangert, Vitor E. Fernandes et autres
Neutrophils and T cells play an important role in host protection against pulmonary infection caused by Streptococcus pneumoniae. However, the role of the integrins in recruitment of these cells to infected lungs is not well understood. In this study we used the …
gb
(code pays fourni par la source)
Accès ouvert
2011
article
OpenAlex
Anja Köhler, Katia De Filippo, Mike Hasenberg, Cindy van den Brandt et autres
Emergency mobilization of neutrophil granulocytes (neutrophils) from the bone marrow (BM) is a key event of early cellular immunity. The hematopoietic cytokine granulocyte-colony stimulating factor (G-CSF) stimulates this process, but it is unknown how individual neutrophils respond in situ. We show by …
de, gb, us
(code pays fourni par la source)