Steven L. Coon

Anatomical and Molecular Characterization of the Zebrafish Meninges

Marina Venero Galanternik, Daniel Castranova, Ryan Gober, Tuyet A. Nguyen et autres

ABSTRACT The meninges are a set of connective tissue layers that surround the central nervous system, protecting the brain from mechanical shock, supporting its buoyancy, guarding it from infection and injury, and maintaining brain homeostasis. Despite their critical role, the molecular identity, …

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Author Correction: TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna‐Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill et autres

The version of the article initially published referred to one, cell line as SK-N-DZ. This line has since been conclusively identified as SK-N-BE(2). The HTML and PDF versions of the article have been updated to reflect this.

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High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities

Michelle Bloyd, Ninet Sinaii, Fábio R. Faucz, James Iben et autres

Introduction: Pediatric obesity has steadily increased in recent decades. Large-scale genome-wide association studies (GWAS) conducted primarily in Eurocentric adult populations have identified approximately 100 loci that predispose to obesity and type II diabetes. GWAS in children and individuals of non-European descent, both …

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A reference human induced pluripotent stem cell line for large-scale collaborative studies

Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough et autres

Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying development and disease, but the considerable phenotypic variation between lines makes it challenging to replicate key findings and integrate data across research groups. To address this issue, we sub-cloned …

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Mitigating Diabetic Foot Ulcers: The Effect of Diet and Microbiome

Steven L. Coon

To truly eliminate the possibility of diabetic foot ulcers, the elimination of the symptoms of diabetes is essential. There are many forms of diabetes and there is no one diet that is effective for all patients. It is essential that a proper …

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The astroglial and stem cell functions of adult rat folliculostellate cells

Patrick A. Fletcher, Kosara Smiljanić, Rafael Maso Prévide, Stéphanie Constantin et autres

The mammalian pituitary gland is a complex organ consisting of hormone-producing cells, anterior lobe folliculostellate cells (FSCs), posterior lobe pituicytes, vascular pericytes and endothelial cells, and Sox2-expressing stem cells. We present single-cell RNA sequencing and immunohistofluorescence analyses of pituitary cells of adult …

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Structural basis of 3′-end poly(A) RNA recognition by LARP1

Guennadi Kozlov, Sandy Mattijssen, Jianning Jiang, Samuel Nyandwi et autres

La-related proteins (LARPs) comprise a family of RNA-binding proteins involved in a wide range of posttranscriptional regulatory activities. LARPs share a unique tandem of two RNA-binding domains, La motif (LaM) and RNA recognition motif (RRM), together referred to as a La-module, but …

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Modeling SARS-CoV-2 and influenza infections and antiviral treatments in human lung epithelial tissue equivalents

Hoda Zarkoob, Anna Allué‐Guardia, Yu‐Chi Chen, Andreu Garcia‐Vilanova et autres

There is a critical need for physiologically relevant, robust, and ready-to-use in vitro cellular assay platforms to rapidly model the infectivity of emerging viruses and develop new antiviral treatments. Here we describe the cellular complexity of human alveolar and tracheobronchial air liquid …

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TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna‐Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss, Sarah E. Hill et autres

Abstract Variants of UNC13A , a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia 1–3 , two related neurodegenerative diseases defined by mislocalization of the RNA-binding protein TDP-43 4,5 . Here we show that TDP-43 …

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The Pineal Transcriptome Webpage

David C. Klein, Steven L. Coon

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Preparation of Single Pineal Cells

Steven L. Coon, David C. Klein

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RNA Sequencing of Single Pineal Cells

Steven L. Coon, David C. Klein

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