Accès ouvert
2026
article
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, Aleksandra Potapova, John Prevedel et autres
Meningeal cerebrovascular injuries (mCVI) trigger prolonged bleeding and inflammation that contribute to long-term neurological dysfunction, yet the immune–vascular dynamics governing meningeal repair remain poorly understood. Existing animal models limit direct observation of these processes due to invasive procedures and restricted optical access …
us
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, Aleksandra Potapova, John Prevedel et autres
Abstract Meningeal cerebrovascular injuries (mCVI) trigger prolonged bleeding and inflammation that contribute to long-term neurological dysfunction, yet the immune–vascular dynamics governing meningeal repair remain poorly understood. Existing animal models limit direct observation of these processes due to invasive procedures and restricted optical …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, Aleksandra Potapova, John Prevedel et autres
Supplementary Material 1.
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, Aleksandra Potapova, John Prevedel et autres
Supplementary Material 1.
us
(code pays fourni par la source)
Accès ouvert
2026
other
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, Aleksandra Potapova, John Prevedel et autres
Abstract Meningeal cerebrovascular injuries (mCVI) trigger prolonged bleeding and inflammation that contribute to long-term neurological dysfunction, yet the immune–vascular dynamics governing meningeal repair remain poorly understood. Existing animal models limit direct observation of these processes due to invasive procedures and restricted optical …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jong Seung Park, Justin Gutkowski, Daniel Castranova, Madeleine I. Kenton et autres
The pulmonary vasculature plays a critical role in gas exchange and in lung pathologies, but it is challenging to observe and experimentally manipulate deep within the lungs of living mammals. Unlike mammalian lungs, externally located zebrafish gills are readily accessible for high-resolution …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Aurora Kraus, Jean S. Prosper-Santiago, John Prevedel, Daniel Castranova et autres
Nearly 1.4 million people in the United States sustain a traumatic brain injury (TBI) each year, with almost half of those hospitalized for TBI developing long-term disability. For many patients, prolonged bleeding and inflammation from damaged vessels in the meninges result in …
us, Cameroun
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Kiyohito Taimatsu, John Prevedel, Daniel Castranova, Kanako Inoue et autres
Zebrafish (Danio rerio) is a valuable model organism for studying developmental processes due to its external development and the optical clarity of its embryos and larvae. However, as development proceeds, zebrafish form increasingly opaque tissues that impede visualization of deep tissues and …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Miranda Marvel, Aniket V. Gore, Kiyohito Taimatsu, Daniel Castranova et autres
Epigenetic reprogramming contributes to the generation of cellular diversity during vertebrate development but the mechanisms directing this are still not well understood. Large-scale genetic screens have been highly successful in identifying epigenetic regulatory genes in invertebrates such as worms and flies, but …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jian Ming Khor, Isabella Cisneros, Miranda Marvel, Aniket V. Gore et autres
Abstract Tissue regeneration requires previously differentiated cells to regain developmental plasticity. However, the upstream mechanisms initiating this process remain poorly understood. Here, we leverage a novel “EpiTag” transgenic zebrafish reporter line that enables real-time visualization of epigenetic silencing and activation to identify …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Marina Venero Galanternik, Daniel Castranova, Ryan Gober, Tuyet A. T. Nguyen et autres
ABSTRACT The meninges are a set of connective tissue layers that surround the central nervous system, protecting the brain from mechanical shock, supporting its buoyancy, guarding it from infection and injury, and maintaining brain homeostasis. Despite their critical role, the molecular identity, …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Kiyohito Taimatsu, John Prevedel, Daniel Castranova, Kanako Inoue et autres
ABSTRACT Zebrafish (Danio rerio) is a valuable model organism for studying developmental processes due to its external development and the optical clarity of its embryos and larvae. However, as development proceeds zebrafish form increasingly opaque tissues that impede visualization of deep tissues …
Cameroun
(code pays fourni par la source)