Andreu Garcia‐Vilanova

Identification of protective human monoclonal antibodies using a K18 hACE2 transgenic mouse SARS-CoV-2 challenge model

Bhavesh R. Borate, Paula A. Pino, Amberlee Hicks, Juan Ignacio García et autres

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses human angiotensin converting enzyme 2 (hACE2) as its obligate receptor for cell entry. The K18 hACE2 transgenic mouse line, which expresses hACE2 under control of …

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Impact of the elderly lung mucosa on Mycobacterium tuberculosis transcriptional adaptation during infection of alveolar epithelial cells

Angélica M. Olmo-Fontánez, Anna Allué‐Guardia, Andreu Garcia‐Vilanova, Jeremy P. Glenn et autres

ABSTRACT Tuberculosis is one of the leading causes of death due to a single infectious agent. Upon infection, Mycobacterium tuberculosis ( M.tb ) is deposited in the alveoli and encounters the lung mucosa or alveolar lining fluid (ALF). We previously showed that, …

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Mitochondrial Transplantation Promotes Protective Effector and Memory CD4 + T Cell Response During Mycobacterium Tuberculosis Infection and Diminishes Exhaustion and Senescence in Elderly CD4 + T cells

Colwyn Ansel Headley, Shalini Gautam, Angélica M. Olmo-Fontánez, Andreu Garcia‐Vilanova et autres

Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis ( M.tb ), is a major global health concern, particularly affecting those with weakened immune systems, including the elderly. CD4 + T cell response is crucial for immunity against M.tb , but chronic infections and …

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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance

Andreu Garcia‐Vilanova, Anna Allué‐Guardia, Nadine M. Chacon, Anwari Akhter et autres

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Impact of the elderly lung mucosa on Mycobacterium tuberculosis metabolic adaptation during infection of alveolar epithelial cells

Angélica M. Olmo-Fontánez, Anna Allué‐Guardia, Andreu Garcia‐Vilanova, Jeremy P. Glenn et autres

ABSTRACT Background Tuberculosis (TB) is one of the top leading causes of death due to a single infectious agent. Upon infection, Mycobacterium tuberculosis ( M.tb ) is deposited in the alveoli and encounters the lung mucosa or alveolar lining fluid (ALF). We …

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Exposure of Mycobacterium tuberculosis to human alveolar lining fluid shows temporal and strain-specific adaptation to the lung environment

Anna Allué‐Guardia, Andreu Garcia‐Vilanova, Alyssa M. Schami, Angélica M. Olmo-Fontánez et autres

Upon infection, Mycobacterium tuberculosis (M.tb) reaches the alveolar space and comes in close contact with the lung mucosa or human alveolar lining fluid (ALF) for an uncertain period of time prior to its encounter with alveolar cells. We showed that homeostatic ALF …

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Mitochondrial Transplantation promotes protective effector and memory CD4 + T cell response during Mycobacterium tuberculosis infection and diminishes exhaustion and senescence in elderly CD4 + T cells

Colwyn Ansel Headley, shalini Guatam, Angélica M. Olmo-Fontánez, Andreu Garcia‐Vilanova et autres

Abstract Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis ( M.tb ), remains a significant health concern worldwide, especially in populations with weakened or compromised immune systems, such as the elderly. Proper adaptive immune function, particularly a CD4 + T cell response, …

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Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis intracellular growth and translocation into the cytosol of alveolar epithelial cells

Angélica M. Olmo-Fontánez, Julia M. Scordo, Alyssa M. Schami, Andreu Garcia‐Vilanova et autres

The elderly population is highly susceptible to developing respiratory diseases, including tuberculosis, a devastating disease caused by the airborne pathogen Mycobacterium tuberculosis (M.tb) that kills one person every 18 seconds. Once M.tb reaches the alveolar space, it contacts alveolar lining fluid (ALF), …

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HIV infection impairs the host response to Mycobacterium tuberculosis infection by altering surfactant protein D function in the human lung alveolar mucosa

Anwari Akhter, Juan I. Moliva, Abul Kalam Azad, Angélica M. Olmo-Fontánez et autres

Tuberculosis is the leading cause of death for people living with HIV (PLWH). We hypothesized that altered functions of innate immune components in the human alveolar lining fluid of PLWH (HIV-ALF) drive susceptibility to Mycobacterium tuberculosis (M.tb) infection. Our results indicate a …

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An Optimized P. berghei Liver Stage–HepG2 Infection Model for Simultaneous Quantitative Bioimaging of Host and Parasite Nascent Proteomes

James L. McLellan, Andreu Garcia‐Vilanova, Kirsten K. Hanson

-infected HepG2 recovery and reseeding protocol presented here is of use in applications beyond nascent proteome labeling and quantification.

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Extracellular Delivery of Functional Mitochondria Rescues the Dysfunction of CD4 + T Cells in Aging

Colwyn Ansel Headley, Shalini Gautam, Angélica M. Olmo-Fontánez, Andreu Garcia‐Vilanova et autres

Abstract Mitochondrial dysfunction alters cellular metabolism, increases tissue oxidative stress, and may be principal to the dysregulated signaling and function of CD4 + T lymphocytes in the elderly. In this proof of principle study, it is investigated whether the transfer of functional …

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HIV Infection impairs the Host Response to Mycobacterium tuberculosis Infection by altering Surfactant Protein D function in the Human Lung Alveolar Mucosa

Anwari Akhter, Juan I. Moliva, Abul Azad, Angélica M. Olmo-Fontánez et autres

ABSTRACT Tuberculosis is the leading cause of death for people living with HIV (PLWH). We hypothesized that altered functions of innate immune components in the human alveolar lining fluid of PLWH (HIV-ALF), drive susceptibility to Mycobacterium tuberculosis ( M.tb ) infection. Our …

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