David C. Klein

CO-002. MODULACIÓN EPIGENÉTICA DE LA AUTOINMUNIDAD EN DIABETES TIPO 1: MIR-30D-5P PROMUEVE LA INMUNORREGULACIÓN EN LINFOCITOS T Y LA REGENERACIÓN DE CÉLULAS BETA

David C. Klein, Liliana Muñoz, D. Perna Barrull, Mayur Doke et autres

Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV

Michael T. Lu, Heather J. Ribaudo, Borek Foldyna, Markella V. Zanni et autres

Importance: Cardiovascular disease (CVD) is increased in people with HIV (PWH) and is characterized by premature noncalcified coronary plaque. In the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), pitavastatin reduced major adverse cardiovascular events (MACE) by 35% over a median …

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Two-Dimensional Thin Layer Chromatography of Melatonin and Related Compounds

David C. Klein

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The Pineal Transcriptome Webpage

David C. Klein, Steven L. Coon

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Preparation of Single Pineal Cells

Steven L. Coon, David C. Klein

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RNA Sequencing of Single Pineal Cells

Steven L. Coon, David C. Klein

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Surgical Techniques and Nuances for Superior Cervical Ganglionectomy and Decentralization in Rats

Sarosh Irfan Madhani, David C. Klein, Estela M. Muñoz, Luis Savastano

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Resource: A multi‐species multi‐timepoint transcriptome database and webpage for the pineal gland and retina

Eric Terry Wang Wei-Chiao Chang, Cong Fu, Steven L. Coon, Shahar Alon et autres

The website and database https://snengs.nichd.nih.gov provides RNA sequencing data from multi-species analysis of the pineal glands from zebrafish (Danio rerio), chicken (White Leghorn), rat (Rattus novegicus), mouse (Mus musculus), rhesus macaque (Macaca mulatta), and human (Homo sapiens); in most cases, retinal data …

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Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland

Mikkel Bloss Carstensen, H Hertz, Tenna Bering, Morten Møller et autres

The pineal gland is a neuroendocrine organ responsible for production of the nocturnal hormone melatonin. A specific set of homeobox gene-encoded transcription factors govern pineal development, and some are expressed in adulthood. The brain-specific homeobox gene (Bsx) falls into both categories. We …

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The Lhx4 homeobox transcript in the rat pineal gland: Adrenergic regulation and impact on transcripts encoding melatonin‐synthesizing enzymes

H Hertz, Mikkel Bloss Carstensen, Tenna Bering, Kristian Rohde et autres

Homeobox genes generally encode transcription factors involved in regulating developmental processes. In the pineal gland, a brain structure devoted to nocturnal melatonin synthesis, a number of homeobox genes are also expressed postnatally; among these is the LIM homeobox 4 gene (Lhx4). We …

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Single Cell Sequencing of the Pineal Gland: The Next Chapter

Steven L. Coon, Cong Fu, Steven W. Hartley, Lynne A. Holtzclaw et autres

The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. Identification of at least nine distinct cell types in …

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The Molecular Basis of the Pineal Melatonin Rhythm: Regulation of Serotonin N-Acetylation

David C. Klein, Rubén Baler, Patrick H. Roseboom, Joan L. Weller et autres

This chapter describes conserved and species-specific features of melatonin rhythm-generating systems. The source of circulating melatonin is the pineal gland, which can be considered to be the melatonin factory. One functional advantage of an endogenous clock which drives melatonin synthesis — as …