Yu‐Chi Chen

Cordyceps sinensis polysaccharide disrupts the macrophage pyroptosis-neutrophil extracellular traps axis to ameliorate acute lung injury

Jingwen Xu, S T Chen, Shushu Xie, Fangmei Zhou et autres

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Unraveling placental immunity: a 3D model of the human placenta barrier to study trimester-specific inflammatory responses 2536

Justine C. Noel, Cristina Antich Acedo, Yu‐Chi Chen, Min Jae Song et autres

Abstract Description Placental dysfunction compromises fetal health, leading to serious pregnancy complications like intrauterine growth restriction and preterm birth. Understanding the mechanisms of such dysregulation is critical for improving maternal-fetal health outcomes. To address limitations of existing models, we developed an in …

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Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress

Chi Zhang, Hao Wang, Zhuoen He, Jinyue He et autres

BACKGROUND: Skeletal muscle atrophy is frequently observed in patients with chronic kidney disease (CKD), exacerbating disease progression and diminishing patients' quality of life. Cinnamic acid (CINN), a low-toxicity phenolic acid derived from Cinnamomum cassia (L.) J. Presl, remains uncharacterized in terms of …

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Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutation

Marc Ferrer, Jiajing Zhang, Yi Wei Lim, Angelica Medina et autres

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Tetrahydroxy stilbene glucoside promotes hair regeneration by inducing Th22 cell differentiation

Lingjie Zhang, Nana Tao, Yu‐Chi Chen, Jie Xu et autres

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Tetrastigma hemsleyanum Diels et Gilg polysaccharide mitigates macrophage pyroptosis and prevents acute lung injury by regulating NLRP3/Caspase-1/GSDMD signaling pathways

Ying Guo, Jingwen Xu, Yuxiang Qi, Fangmei Zhou et autres

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[Analysis and Prediction of Soil Erosion Under Different Land Use Change Scenarios in Kuye River Basin Based on PLUS-CSLE Model].

Yu‐Chi Chen, Yuan He, Ahmd Ehab Talat, Jian Wang et autres

. The ecological protection scenario was better for controlling the soil erosion. ④ The areas with the most soil erosion in the basin were mainly the grassland and farmland in the loess gully in the central and southern parts, as well as …

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P‐Coumaric Acid Improves Skeletal Muscle Atrophy in Chronic Kidney Disease by Modulating TLR4 / MyD88 / NF ‐ κB ‐Mediated Inflammation and Oxidative Stress

Hao Wang, Chi Zhang, Jinyue He, Zhuoen He et autres

Skeletal muscle atrophy is a prevalent complication in chronic kidney disease (CKD), and its pathogenesis is closely related to inflammation and oxidative stress. P-Coumaric acid (PCA) is a phenolic acid with anti-inflammatory and antioxidant pharmacological actions. This research aims to investigate the …

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Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song et autres

Abstract Flaviviruses can lead to severe neurotropic‐encephalitic pathology, for which the viral nonstructural protein 1 (NS1) plays a major role. 2D in vitro cellular systems and animal models are currently used to investigate the effects of flavivirus NS1 in the brain‐blood barrier …

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Melastoma dodecandrum polysaccharide alleviates allergic rhinitis in mice through modulating NLRP3 and IL-17 axis

Jingwen Xu, Youying Tang, Chenjun Shen, Kewei Li et autres

Allergic rhinitis (AR) is a prevalent nasal disorder characterized by chronic inflammation and hypersensitivity, with limited effective treatments. Melastoma dodecandrum polysaccharide (MDP), derived from a medicinal herb, exhibits anti-inflammatory and immunomodulatory properties, making it a potential therapeutic candidate for AR. This study …

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Managing telomerase and telomere dysfunction in acral melanoma

Vishnu Sravan Bollu, Yu‐Chi Chen, Fan Zhang, Krishne Gowda et autres

Acral Lentiginous Melanoma is a rare and aggressive subtype of melanoma that commonly affects the palms, soles, and nail beds. It is more prevalent in individuals with darker skin tones, including Asian, African, and Hispanic populations. Unlike cutaneous melanomas, acral melanoma is …

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Quantification of the Loess Plateau's soil hydrodynamics in relation to bulk density

Ahmed Ehab Talat, Yu‐Chi Chen, Yuan He, Zekang Cai et autres

Abstract Investigating the effects of varying degrees of soil compaction on its hydrodynamic properties is still a vital step in optimizing water utilization. Furthermore, hydrodynamic parameters such as saturated hydraulic conductivity (Ks) and soil water retention characteristics (SWRC) are essential data for …

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