Accès ouvert
2025
article
OpenAlex
Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund et autres
Immunotherapies such as immune checkpoint inhibitors are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer. Here we engineered liposomal nanoparticles carrying a poly-ʟ-arginine/poly-ʟ-glutamate coating that promotes their binding and retention on the surface …
us
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Accès ouvert
2024
preprint
OpenAlex
Ivan Susin Pires, Gil Covarrubias, Victoria F. Gomerdinger, Coralie M. Backlund et autres
Immunotherapies such as checkpoint inhibitors (CPI) are effective in treating several advanced cancers, but these treatments have had limited success in metastatic ovarian cancer (OC). Here, we engineered liposomal nanoparticles (NPs) carrying a layer-by-layer (LbL) polymer coating that promotes their binding to …
us
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Nicholas L. Truex, Aurélie Rondon, Simon L. Rössler, Cameron C. Hanna et autres
High Resolution Image Download MS PowerPoint Slide Molecular vaccines comprising antigen peptides and inflammatory cues make up a class of therapeutics that promote immunity against cancer and pathogenic diseases but often exhibit limited efficacy. Here, we engineered an antigen peptide delivery system …
us
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Accès ouvert
2023
article
OpenAlex
Kim Bich Nguyen, Malte Roerden, Christopher Copeland, Coralie M. Backlund et autres
Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the molecular determinants of resistance have not been …
us, ru
(code pays fourni par la source)
Accès ouvert
2023
peer-review
OpenAlex
Kim Bich Nguyen, Malte Roerden, Christopher Copeland, Coralie M. Backlund et autres
In vivo modeling of neoantigen-restricted heterogeneity shows that clonal expression of neoantigens enhances anti-tumor T cell responses by increasing the stimulatory capacity of dendritic cells in the lymph node.
us, ru
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Angela Q. Zhang, Alexander Hostetler, Laura E. Chen, Vainavi Mukkamala et autres
The effectiveness of chimaeric antigen receptor (CAR) T cell therapies for solid tumours is hindered by difficulties in the selection of an effective target antigen, owing to the heterogeneous expression of tumour antigens and to target antigen expression in healthy tissues. Here …
us
(code pays fourni par la source)
Accès ouvert
2023
review
OpenAlex
Coralie M. Backlund, Sasan Jalili‐Firoozinezhad, Byungji Kim, Darrell J. Irvine
Modulation of the immune system is an important therapeutic strategy in a wide range of diseases, and is fundamental to the development of vaccines. However, optimally safe and effective immunotherapy requires precision in the delivery of stimulatory cues to the right cells …
us
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Kim Bich Nguyen, Christopher Copeland, Coralie M. Backlund, Nory G Klop-Packel et autres
Abstract Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the molecular determinants of resistance have not …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Coralie M. Backlund, Rebecca L. Holden, Kelly Dare Moynihan, Daniel Garafola et autres
Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest immunogenicity. One approach that has been explored to enhance peptide vaccine potency is covalent conjugation of antigens with cell-penetrating peptides (CPPs), linear cationic and amphiphilic peptide sequences designed to promote …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong Ha Kang et autres
While immune checkpoint blockade results in durable responses for some patients, many others have not experienced such benefits. These treatments rely upon reinvigorating specific T cell-antigen interactions. However, it is often unknown what antigens are being recognized by T cells or how …
us
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Eric L. Dane, Alexis Belessiotis‐Richards, Coralie M. Backlund, Jianing Wang et autres
Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We conjugated STING-activating cyclic dinucleotides (CDNs) to PEGylated lipids (CDN-PEG-lipids; PEG, polyethylene glycol) via a cleavable linker and …
us, gb, jp
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong Ha Kang et autres
Abstract While immune checkpoint blockade results in durable responses for some patients, many others have not experienced such benefits. These treatments rely upon reinvigorating specific T cell-antigen interactions. However, it is often unknown what antigens are being recognized by T cells or …
us
(code pays fourni par la source)