Li-Nan Chen

Core conformation of arrestin coupling to parathyroid hormone type 1 receptor

Xiuwen Zhai, Jia Guo, Qingya Shen, Li-Nan Chen et autres

The recruitment of β-arrestin (βarr) by G-protein-coupled receptor (GPCR) holds imperative importance in physiological processes, while the mechanisms underlying arrestin engagement with receptors remain obscure. The parathyroid hormone type 1 receptor (PTH1R), as a prototypical class B1 receptor, incorporates arrestin for signaling …

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The molecular basis of μ-opioid receptor signaling plasticity

Huibing Zhang, Xueting Wang, Kun Xi, Qingya Shen et autres

Abstract Activation of the μ-opioid receptor (μOR) alleviates pain but also elicits adverse effects through diverse G proteins and β-arrestins. The structural details of μOR complexes with G z and β-arrestins have not been determined, impeding a comprehensive understanding of μOR signaling …

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Efficacy of sacral nerve magnetic stimulation in preventing urinary retention after total hysterectomy: a randomised controlled trial

Li-Nan Chen, Shuyun Zhang, Y.H. Qin

Background Urinary retention following total hysterectomy is a prevalent postoperative complication that significantly impacts patient recovery and quality of life. Current prevention methods have limitations, prompting exploration of more effective strategies. Sacral nerve magnetic stimulation (SMS), an innovative, non-invasive approach, has shown …

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Teleost HMGB1 paralogues mediate protective autophagy by interacting with NOD2 and ATG16L1 and activating ROS/Akt/mTOR pathway against Aeromonas hydrophila infection

Dan Wang, Li-Nan Chen, Xiaoyu Ma, Zhe Wang et autres

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Edwardsiella piscicida effector EseD mediates ferritinophagy by targeting NCOA4 and STING in teleost cells

Jingqi Ren, Li-Nan Chen, Rong Ye, Dan Xiong et autres

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Suppression of NRAS-mutant melanoma growth with NRAS-targeting Antisense Oligonucleotide treatment reveals therapeutically relevant kinase co-dependencies

Valentin Feichtenschlager, Yixuan James Zheng, Tiange Qu, Dasha Hohlova et autres

BACKGROUND: Melanoma is an aggressive form of skin cancer, and patients with NRAS-mutant melanoma face limited treatment options due to the lack of direct NRAS inhibitors. This study explores the utilization of antisense oligonucleotides (ASOs) to directly target NRAS-mRNA for therapeutic approaches. …

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Transformational Leadership and Sensemaking in Sustainable Strategic Change Aligned with the Sdgs: A Case Study of a Higher Education Institution Pursuing University Status

Hong Liang Yang, Li-Nan Chen, Zehong Wang, Chao Zhang et autres

Objective: This paper investigates how transformational leadership engages in sensemaking to drive sustainable strategic transformation in Chinese higher education institutions, particularly those striving for university status under the 14th Five-Year Plans. Aligned with SDG 4.7, it emphasizes how HEIs construct strategic direction …

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Enhancing High-Rate Performance and Cyclability of LiFePO4 Cathode Materials for Lithium-Ion Batteries by Optimizing the Li/Fe Ratio

Baitao Su, Yite Liu, Li-Nan Chen, Aishui Yu

Lithium iron phosphate (LiFePO 4 ) has garnered significant attention as a key cathode material for lithium-ion batteries due to its exceptional safety, long cycle life, and environmentally friendly characteristics. However, its electrochemical performance is influenced by several factors, with the Li/Fe …

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Proton perception and activation of a proton-sensing GPCR

Li-Nan Chen, Hui Zhou, Kun Xi, Shizhuo Cheng et autres

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Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang et autres

The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large extracellular region, plays a pivotal role in auditory function through Gi2/3. Here, we firstly demonstrate that GPR156 with high constitutive activity is essential for maintaining auditory function, and further reveal …

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Molecular insights into the atypical activation mechanism of GPR156 in maintaining auditory function

Xiangyu Ma, Li-Nan Chen, Menghui Liao, Liyan Zhang et autres

Abstract The class C orphan GPCR GPR156, which lacks the typical extracellular region, plays a pivotal role in auditory function through G i2/3 . Here, we demonstrate that GPR156 with high constitutive activity is essential for maintaining auditory function, and we further …

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Structure-based design of non-hypertrophic apelin receptor modulator

Weiwei Wang, Su‐Yu Ji, Wenjia Zhang, Junxia Zhang et autres

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