Valentin Feichtenschlager

LB1227 Synergizing ASOs unveil MAPK pathway associated vulnerabilities in drug resistant melanoma

Valentin Feichtenschlager, Dasha Hohlova, Ciara Callanan, José Ortiz et autres

Suppression of NRAS-mutant melanoma growth with NRAS-targeting Antisense Oligonucleotide treatment reveals therapeutically relevant kinase co-dependencies

Valentin Feichtenschlager, Yixuan James Zheng, Tiange Qu, Dasha Hohlova et autres

BACKGROUND: Melanoma is an aggressive form of skin cancer, and patients with NRAS-mutant melanoma face limited treatment options due to the lack of direct NRAS inhibitors. This study explores the utilization of antisense oligonucleotides (ASOs) to directly target NRAS-mRNA for therapeutic approaches. …

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LB1005 Suppression of NRAS-mutant melanoma growth with NRAS-targeting ASO treatment reveals therapeutically relevant kinase co-dependencies

Valentin Feichtenschlager, Yi Zheng, Ting Qu, Dasha Hohlova et autres

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The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

Valentin Feichtenschlager, Li-Nan Chen, Yixuan James Zheng, Wilson Wai-Shing Ho et autres

Finding effective therapeutic targets to treat NRAS-mutated melanoma remains a challenge. Long non-coding RNAs (lncRNAs) recently emerged as essential regulators of tumorigenesis. Using a discovery approach combining experimental models and unbiased computational analysis complemented by validation in patient biospecimens, we identified a …

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The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

Valentin Feichtenschlager, Li-Nan Chen, Yixuan James Zheng, Wilson Wai-Shing Ho et autres

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The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cell survival in NRAS/MAPK-driven melanoma

Valentin Feichtenschlager, Li-Nan Chen, Yixuan James Zheng, Wilson Wai-Shing Ho et autres

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Deconstructing the role of MALAT1 in MAPK-signaling in melanoma: insights from antisense oligonucleotide treatment

Valentin Feichtenschlager, Yixuan James Zheng, Wilson Wai-Shing Ho, Li-Nan Chen et autres

// Valentin Feichtenschlager 1 , 2 , Yixuan James Zheng 1 , 3 , Wilson Ho 1 , Linan Chen 1 , Ciara Callanan 1 , Christopher Chen 1 , Albert Lee 1 , Jose Ortiz 1 , Klemens Rappersberger 2 and …

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The long non-coding RNA ‘TRASH’ is essential for cell survival in MAPK-driven melanoma

Valentin Feichtenschlager, Li-Nan Chen, Yixuan James Zheng, Wilson Wai-Shing Ho et autres

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672 Targeting lncRNAs AC and BX reveals their critical role in melanoma and allows to identify novel phosphor-catalytic vulnerabilities

Valentin Feichtenschlager, Marin Vujic, Igor Vujic, C. Chen et autres

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184 Discovering the hidden elements of cancer: Targeting the lncrna ac004540.4 reveals its critical role in nras mutant melanoma

Valentin Feichtenschlager, L. Chen, Marin Vujic, A. Lee et autres

185 The antisense lncRNA transcript RP11-7O11.3: Shedding light upon a novel and crucial player in NRAS mutant melanoma

L. Chen, Valentin Feichtenschlager, Marin Vujic, A. Lee et autres

497 Eleven years of melanoma patient management – observations and trends from a single-center study in Austria

Christian Posch, Valentin Feichtenschlager, Felix Weihsengruber, Klemens Rappersberger

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