Wenjia Zhang

Niemann-Pick C1 maintains cholesterol homeostasis in late endosomes to drive hepatitis B virus endosomal escape

Siyi He, Wenjia Zhang, Chunduo Wang, Ranran Li et autres

Hepatitis B virus (HBV) infection poses a major global health burden, as current nucleos(t)ide analogs and interferon-alpha (IFN-α) cannot eradicate the viral reservoir. Host factors play an indispensable regulatory role in enabling HBV to establish persistent infection. While host factors governing early …

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Molecular Mechanisms Underlying Human Vγ9Vδ2 T Cell Activation by Butyrophilin-3 (BTN3) Targeted Antibodies

Bangdong Huang, Weizhi Xin, Wenjia Zhang, Weijie Gao et autres

Abstract γδ T cells express T cell receptors (TCRs) composed of paired γ and δ chains. The Vγ9Vδ2 T cells are the main subpopulation of γδ T cells in human peripheral blood, which responds to phosphoantigens (pAgs) through butyrophilins (BTN) molecules, such …

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Multicarrier Nanoplatforms for Precise Targeting of Cellular Energy Centers in Ischemic Heart Disease Therapy

Wenjia Zhang, Hui Jin Xiao, Yinfa Ma, Kai Li et autres

High Resolution Image Download MS PowerPoint Slide Mitochondria, as the core organelle of cellular energy metabolism and fate regulation, not only maintain the balance between myocardial reactive oxygen species ROS and energy metabolism but also regulate key pathological processes such as apoptosis, …

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Phosphoantigen-Driven Dissociation of Butyrophilin Oligomers Activates γδ T Cells

Weizhi Xin, Bangdong Huang, Weijie Gao, Wenjia Zhang et autres

Abstract γδ T cells represent a promising avenue for cancer immunotherapy. The Vγ9Vδ2 T cell receptor (TCR), expressed by the predominant subset of γδ T cells, responds to phosphoantigen (pAg)-engaged butyrophilins (BTNs) on various cancer cells. However, the molecular mechanism underlying pAg-mediated …

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The role of succinylation-mediated metabolic reprogramming in tumor progression

Siyi He, Chunduo Wang, Ranran Li, Kexin Xu et autres

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EGFR/ZBED1 reciprocal regulation promotes stemness and tumorigenesis in glioblastoma

Nana Hou, Yutao Wang, Qiuxiang You, Lei Zhang et autres

BACKGROUND: Glioblastoma stem cells (GSCs), a stem-like tumorigenic subpopulation within glioblastoma (GBM), exhibit remarkable self-renewal capacity and therapeutic resistance. Zinc finger BED domain-containing protein 1 (ZBED1), a dual-function transcription factor and SUMO E3 ligase, has been implicated in oncogenic processes across malignancies, …

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The influences of ARHGEF9 on myoblasts migration and differentiation

Shuang Li, Jin Xu, Wenjia Zhang, Yongze Liu et autres

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Structure-based design of non-hypertrophic apelin receptor modulator

Weiwei Wang, Su‐Yu Ji, Wenjia Zhang, Junxia Zhang et autres

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Vitamin A Promotes the Repair of Mice Skeletal Muscle Injury through RARα

Wenjia Zhang, Q. Peng, Xiaoyu Zhang, Jiaxu Guo et autres

Vitamin A (VitA) is an important fat-soluble vitamin which plays an important role in cell growth and individual development. However, the effect of VitA on the repair process of muscle injury and its molecular mechanism are still unclear. In this study, VitA …

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Bacterial driver–passenger model in biofilms: a new mechanism in the development of colorectal cancer

Junqiang Xing, Yongkun Fang, Wenjia Zhang, Hao Zhang et autres

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Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution

Rahul Krishnan, Bala Yarlagadda, Pravin L. Kotian, Kevin J. Polach et autres

MiR-195 inhibits myocardial fibrosis in hypertensive rats by regulating TGFβ1-Smad3 signaling pathway

Qingdong Xu, Xuanzi Lin, P. Liu, Wenjia Zhang et autres

The article “MiR-195 inhibits myocardial fibrosis in hypertensive rats by regulating TGFβ1-Smad3 signaling pathway, by Q. Xu, X.-X. Lin, P. Liu, W. Zhang, K. Tang, Y.-S. Zhai, L.-J. Liu, W.-Y. Mei, published in Eur Rev Med Pharmacol Sci 2019; 23 (18): 8087-8094–DOI: …

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