Xiuwen Zhai

Core Conformation of Arrestin Coupling to Parathyroid Hormone Type 1 Receptor

Xiuwen Zhai

the map and pdb file of PHT1R-βarr1 complexes

Core Conformation of Arrestin Coupling to Parathyroid Hormone Type 1 Receptor

Xiuwen Zhai

the map and pdb file of PHT1R-βarr1 complexes

Core conformation of arrestin coupling to parathyroid hormone type 1 receptor

Xiuwen Zhai, Jia Guo, Qingya Shen, Li-Nan Chen et autres

The recruitment of β-arrestin (βarr) by G-protein-coupled receptor (GPCR) holds imperative importance in physiological processes, while the mechanisms underlying arrestin engagement with receptors remain obscure. The parathyroid hormone type 1 receptor (PTH1R), as a prototypical class B1 receptor, incorporates arrestin for signaling …

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Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation

Xiuwen Zhai, Chunyou Mao, Qingya Shen, Shao‐Kun Zang et autres

homeostasis. Teriparatide (PTH) and Abaloparatide (ABL) are terms as long-acting and short-acting peptide, respectively, regarding their marked duration distinctions of the downstream signaling. However, the mechanistic details remain obscure. Here, we report the cryo-electron microscopy structures of PTH- and ABL-bound PTH1R-Gs complexes, …

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Molecular insights into the distinct signaling duration for the peptide-induced PTH1R activation

Zhihong Liu, Xiuwen Zhai, Chunyou Mao, Qingya Shen et autres

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