Matías Estarás

Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity

Matías Estarás, Candido Ortiz-Placin, Salomé Martínez-Morcillo, Remigio Martínez et autres

Abstract Lipoxygenases exhibit a leading role in cancer development and growth. Additionally, pancreatic stellate cells (PSCs) are pivotal in the formation of fibrotic tissue in pancreatic tumors. In this work, we have studied the effects of the 5-lipoxygenase (5-LOX) inhibitor, zileuton, on …

es, fr (code pays fourni par la source)

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis

Matías Estarás, Emma Cosialls, Gareth Pollin, Anass Berkachi et autres

Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, we show that stress granules (SGs) formation is a …

fr, us, es (code pays fourni par la source)

Evaluating the therapeutic role of salvianolic acid A on pancreatic cancer cells through interaction with the intrinsically disordered protein NUPR1

Matías Estarás, Felipe Hornos, Bruno Rizzuti, Patricia Santofimia‐Castaño et autres

The nuclear protein 1 (NUPR1) is an intrinsically disordered protein (IDP) involved in stress processes in the cell. We have been developing, by using organic chemistry, several small molecules which hamper in vitro and in cell-based assays NUPR1 biomolecular interactions by targeting …

es, fr (code pays fourni par la source)

Synergistic antitumor activity of sorafenib and the NUPR1 inhibitor LZX-2-73 in multiple cancer models

Xi Liu, Matías Estarás, Emma Cosialls, Ling Peng et autres

Combination therapy in cancer treatment offers significant potential to overcome drug resistance, enhance efficacy, reduce toxicity, and expand drug indications. sorafenib, an FDA-approved multi-targeted kinase inhibitor, has demonstrated effectiveness across various cancers but currently lacks approved combination therapies. Recently, we identified LZX-2-73 …

fr, ar (code pays fourni par la source)

NUPR1-dependent Stress Granules are present in Caerulein-induced chronic pancreatitis models

Matías Estarás, Emma Cosialls, Juan Iovanna, Patricia Santofimia‐Castaño

fr (code pays fourni par la source)

Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Patricia Santofimia‐Castaño, Wenjun Lan, Matías Estarás, Yi Xia et autres

Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a potential therapeutic target. Our laboratory has developed NUPR1 inhibitors such as ZZW-115. In this …

fr, cn, ar (code pays fourni par la source)

The intrinsically disordered protein NUPR1 binds to phospholipids

Matías Estarás, Bruno Rizzuti, Ana Marcela Giudici, José Antonio Poveda et autres

The nuclear protein 1 (NUPR1) is an intrinsically disordered protein (IDP) involved in stress-mediated cellular conditions, with an interactome including many other partner proteins, as well as nucleic acids. We wondered whether its great conformational flexibility and biological versatility could include interactions …

fr, es, it (code pays fourni par la source)

Organosilicon molecules bind to the intrinsically disordered protein NUPR1 by clamping its hot-spots

Laura Fernández-Peña, Matías Estarás, Paula González-Andrés, Carlos Díez‐Poza et autres

ABSTRACT The nuclear protein 1, or NUPR1, is an intrinsically disordered protein (IDP) involved in the development and progression of pancreatic ductal adenocarcinoma (PDAC). We have previously developed drugs capable of binding at the two hot-spot regions of NUPR1, around residues Ala33 …

es, fr, it (code pays fourni par la source)

Oncogenic stress response mechanisms as new therapeutic targets in cancer treatment: A review

Juan Iovanna, Matías Estarás, Daniel Grasso, Martin E. Fernández Zapico et autres

Activation of oncogenes, such as through mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS), triggers profound disruptions in cellular homeostasis that set off a cascade of stress responses. These responses enable cells to cope with the array of challenges encountered during …

fr, ar, us, es (code pays fourni par la source)

KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

Analía Meilerman Abuelafia, Patricia Santofimia‐Castaño, Matías Estarás, Daniel Grasso et autres

• The accumulation of senescent-like cells in tumor tissues because of chemotherapy is linked to treatment resistance, specifically in pancreatic ductal adenocarcinoma (PDAC). • Therapy-induced senescence-like in PDAC is influenced by the mutational status of KRAS, affecting the response to chemotherapeutic agents. …

fr, ar, us (code pays fourni par la source)

Activation of lysosomal iron triggers ferroptosis in cancer

Tatiana Cañeque, Leeroy Baron, Sebastian Müller, Alanis Carmona et autres

Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. …

fr, us, de, ca (code pays fourni par la source)

KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

Miriam Analia Meilerman Abuelafia, Patricia Santofimia‐Castaño, Matías Estarás, Daniel Grasso et autres

BackgroundEmerging evidence suggests that chemotherapy can accumulate senescent-like cells within tumor tissues, a phenomenon linked to therapy resistance. The aim of this study is to analyze the senescence-like state of after-treatment persistent cells associated with KRAS mutational status to offer a therapeutic …

fr, us (code pays fourni par la source)