Patricia Santofimia‐Castaño

Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity

Matías Estarás, Candido Ortiz-Placin, Salomé Martínez-Morcillo, Remigio Martínez et autres

Abstract Lipoxygenases exhibit a leading role in cancer development and growth. Additionally, pancreatic stellate cells (PSCs) are pivotal in the formation of fibrotic tissue in pancreatic tumors. In this work, we have studied the effects of the 5-lipoxygenase (5-LOX) inhibitor, zileuton, on …

es, fr (code pays fourni par la source)

The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung

Jessica Nouws, Saul S. Siller, Tao Yang, Sojin Kim et autres

Chronic obstructive pulmonary disease (COPD) is characterized by chronic injury and oxidative stress leading to progressive lung tissue destruction. Emerging evidence suggests that regulated cell death pathways, particularly ferroptosis, contribute to COPD pathology. We previously identified decreased expression of the stress response …

us, cn, fr, ca (code pays fourni par la source)

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis

Matías Estarás, Emma Cosialls, Gareth Pollin, Anass Berkachi et autres

Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, we show that stress granules (SGs) formation is a …

fr, us, es (code pays fourni par la source)

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis

Marie Zöller, Michal Mastalerz, Elisabeth Dick, Juliane Merl‐Pham et autres

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS exposure in fully differentiated primary human …

de, be, fr, us (code pays fourni par la source)

Nuclear protein 1 is a cell death regulator in primary human airway epithelial cells and reduced in idiopathic pulmonary fibrosis

Marie Zöller, Michal Mastalerz, Elisabeth Dick, Juliane Merl-Pham et autres

The airway epithelium is the first site of injury from cigarette smoke (CS), a major risk factor for chronic lung disease including idiopathic pulmonary fibrosis (IPF). Here, we report the first intracellular proteomic analysis of CS exposure in fully differentiated primary human …

Evaluating the therapeutic role of salvianolic acid A on pancreatic cancer cells through interaction with the intrinsically disordered protein NUPR1

Matías Estarás, Felipe Hornos, Bruno Rizzuti, Patricia Santofimia‐Castaño et autres

The nuclear protein 1 (NUPR1) is an intrinsically disordered protein (IDP) involved in stress processes in the cell. We have been developing, by using organic chemistry, several small molecules which hamper in vitro and in cell-based assays NUPR1 biomolecular interactions by targeting …

es, fr (code pays fourni par la source)

Synergistic antitumor activity of sorafenib and the NUPR1 inhibitor LZX-2-73 in multiple cancer models

Xi Liu, Matías Estarás, Emma Cosialls, Ling Peng et autres

Combination therapy in cancer treatment offers significant potential to overcome drug resistance, enhance efficacy, reduce toxicity, and expand drug indications. sorafenib, an FDA-approved multi-targeted kinase inhibitor, has demonstrated effectiveness across various cancers but currently lacks approved combination therapies. Recently, we identified LZX-2-73 …

fr, ar (code pays fourni par la source)

NUPR1-dependent Stress Granules are present in Caerulein-induced chronic pancreatitis models

Matías Estarás, Emma Cosialls, Juan Iovanna, Patricia Santofimia‐Castaño

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The mitochondrial catastrophe induced by NUPR1 inhibitors as a novel strategy to fight against cancer

Juan Iovanna, José L. Neira, Olga Abián, Adrián Velázquez‐Campoy et autres

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Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Patricia Santofimia‐Castaño, Wenjun Lan, Matías Estarás, Yi Xia et autres

Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a potential therapeutic target. Our laboratory has developed NUPR1 inhibitors such as ZZW-115. In this …

fr, cn, ar (code pays fourni par la source)

The intrinsically disordered protein NUPR1 binds to phospholipids

Matías Estarás, Bruno Rizzuti, Ana Marcela Giudici, José A. Poveda et autres

The nuclear protein 1 (NUPR1) is an intrinsically disordered protein (IDP) involved in stress-mediated cellular conditions, with an interactome including many other partner proteins, as well as nucleic acids. We wondered whether its great conformational flexibility and biological versatility could include interactions …

fr, es, it (code pays fourni par la source)

Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

Dinesh Dhumal, Patricia Santofimia‐Castaño, Juan Liu, Marion Casanova et autres

Cardiotoxicity, especially human ether-a-go-go-related gene (hERG)-related toxicity, is a leading cause of drug failure or market withdrawal. Reducing hERG binding to obviate potential cardiac toxicity is crucial. Nanotechnology has been applied to drug delivery for reducing drug toxicity and improving efficacy, but …

fr, cn (code pays fourni par la source)