Emma Cosialls

Stress granules confer an early vulnerability in KRAS-driven pancreatic tumorigenesis

Matías Estarás, Emma Cosialls, Gareth Pollin, Anass Berkachi et autres

Pancreatic ductal adenocarcinoma (PDAC) is initiated by activating KRAS mutations, yet most pancreatic cells fail to survive the induced oncogenic stress. How a subset adapts to and initiates malignant transformation remains unclear. Here, we show that stress granules (SGs) formation is a …

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Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer

Nadine Abdel Hadi, Gabriela Reyes‐Castellanos, Tristan Gicquel, Scarlett Gallardo-Arriaga et autres

Pancreatic Ductal Adenocarcinoma (PDAC) remains a major unresolved disease because of its remarkable therapeutic resistance. Even patients who respond to initial therapy experience relapse in most cases. The mechanisms underlying therapy-acquired resistance supporting relapse are poorly understood. In this study, we aimed …

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Synergistic antitumor activity of sorafenib and the NUPR1 inhibitor LZX-2-73 in multiple cancer models

Xi Liu, Matías Estarás, Emma Cosialls, Ling Peng et autres

Combination therapy in cancer treatment offers significant potential to overcome drug resistance, enhance efficacy, reduce toxicity, and expand drug indications. sorafenib, an FDA-approved multi-targeted kinase inhibitor, has demonstrated effectiveness across various cancers but currently lacks approved combination therapies. Recently, we identified LZX-2-73 …

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NUPR1-dependent Stress Granules are present in Caerulein-induced chronic pancreatitis models

Matías Estarás, Emma Cosialls, Juan Iovanna, Patricia Santofimia‐Castaño

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Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Patricia Santofimia‐Castaño, Wenjun Lan, Matías Estarás, Yi Xia et autres

Drug resistance remains a major obstacle in treating pancreatic ductal adenocarcinoma (PDAC). Nuclear protein 1 (NUPR1), a stress-responsive protein implicated in cancer progression and treatment resistance, represents a potential therapeutic target. Our laboratory has developed NUPR1 inhibitors such as ZZW-115. In this …

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Mechanisms of induced resistance to the antitumoral agent ZZW-115 in pancreas ductal adenocarcinoma

Patricia Santofimia‐Castaño, Wenjun Lan, Matias Estares, Yi Xia et autres

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mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions

Emma Cosialls, Emeline Pacreau, Clémence Duruel, Sara Ceccacci et autres

Abstract Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by triggering ferroptosis. Here, in a …

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Adverse Crosstalk between Extracellular Matrix Remodeling and Ferroptosis in Basal Breast Cancer

Christophe Desterke, Emma Cosialls, Yao Xiang, Rima Elhage et autres

(1) Background: Breast cancer is a frequent heterogeneous disorder diagnosed in women and causes a high number of mortality among this population due to rapid metastasis and disease recurrence. Ferroptosis can inhibit breast cancer cell growth, improve the sensitivity of chemotherapy and …

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Adverse Crosstalk Between Extracellular Matrix Remodeling and Ferroptosis in Basal Breast Cancer

Christophe Desterke, Emma Cosialls, Yao Xiang, Rima Elhage et autres

(1) Background: Breast cancer is a frequent heterogeneous disorder diagnosed in woman and is a high cause of mortality of them in reason to rapid metastasis and disease recurrence. Ferroptosis can inhibit breast cancer cell growth, improve the sensitivity of chemotherapy and …

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Élimination des cellules souches cancéreuses mammaires par la ferroptose, un bras de fer orchestré par mTOR

Emma Cosialls

Le cancer du sein est le cancer le plus fréquent et le plus meurtrier chez la femme en France, si bien que la lutte contre la résistance aux traitements est un véritable enjeu de santé publique. Au sein de l'hétérogénéité tumorale, il …

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mTOR Inhibition Suppresses Salinomycin-Induced Ferroptosis in Breast Cancer Stem Cells by Ironing Out Mitochondrial Dysfunctions

Emma Cosialls, Emeline Pacreau, Sara Ceccacci, Rima Elhage et autres

ABSTRACT Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin (Sal) was able to eliminate CSCs by triggering ferroptosis. Here, in a …

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Ferroptosis: Cancer Stem Cells Rely on Iron until “to Die for” It

Emma Cosialls, Rima Elhage, Leïla Dos Santos, Chang Gong et autres

Cancer stem cells (CSCs) are a distinct subpopulation of tumor cells with stem cell-like features. Able to initiate and sustain tumor growth and mostly resistant to anti-cancer therapies, they are thought responsible for tumor recurrence and metastasis. Recent accumulated evidence supports that …

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