Fabian Nikolka

ACC1 inhibition enhances BCG-induced trained immunity by reprogramming acetyl-CoA metabolism

İlayda Baydemir, Fabian Nikolka, Özlem Bulut, Anaísa V. Ferreira et autres

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Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV, Inaam Sado et autres

During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting neonatal energy demands. Shortly after birth, lipogenesis begins, driven by transcriptional activation of enzymes …

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Kupffer cells control neonatal hepatic metabolism via Igf1 signaling

Nikola Makdissi, DORIS J. HIRSCHMANN, A. N. FROLOV, Inaam Sado et autres

Abstract During perinatal development, liver metabolism is tightly regulated to ensure energy supply for the newborn. Before birth, glycogen is stored in hepatocytes and later metabolized to glucose, meeting the energy demands of the neonate. Shortly after birth, lipogenesis begins, driven by …

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Metabolization of microbial postbiotic pentanoate drives anti-cancer CAR T cells

Sarah Staudt, Fabian Nikolka, Markus Perl, Julia Franz et autres

The microbiome is a complex host factor and key determinant of the outcome of antibody-based and cellular immunotherapy. Its postbiotics are a blend of soluble commensal byproducts that are released into the host environment and have been associated with the regulation of …

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Anabolic lipid metabolism regulates adipose type 2 innate lymphoid cell differentiation to maintain metabolic health

Maria Rafailia Theodorou, Jiangyan Yu, Fabian Nikolka, Jelena Zurkovic et autres

Summary Group 2 innate lymphoid cells (ILC2) residing in the adipose tissue play an important role in maintaining the metabolic health and energy balance of the organisms. In obesity ILC2 numbers are reduced and their function is impaired, leading to the progression …

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The Virulence Factor Macrophage Infectivity Potentiator (Mip) Influences Branched-Chain Amino Acid Metabolism and Pathogenicity of Legionella pneumophila

Fabian Nikolka, Mustafa Safa Karagöz, Mohamed Zakaria Nassef, Karsten Hiller et autres

Legionella pneumophila (Lp) is a common etiological agent of bacterial pneumonia that causes Legionnaires’ disease (LD). The bacterial membrane-associated virulence factor macrophage infectivity potentiator (Mip) exhibits peptidyl-prolyl-cis/trans-isomerase (PPIase) activity and contributes to the intra- and extracellular pathogenicity of Lp. Though Mip influences …

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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Fotios; https://orcid.org/0000-0002-1030-0635 Karagiannis, Konrad Peukert, Laura; https://orcid.org/0000-0001-8152-0611 Surace, Marcel Michla et autres

Anorexia and fasting are host adaptations to acute infection, inducing a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB) 1-6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we report impaired …

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Fotios Karagiannis, Konrad Peukert, Laura Surace, Marcel Michla et autres

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Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages

Wei He, Antonia Henne, Mario A. R. Lauterbach, Eike Geißmar et autres

Since its discovery in inflammatory macrophages, itaconate has attracted much attention due to its antimicrobial and immunomodulatory activity1–3. However, instead of investigating itaconate itself, most studies used derivatized forms of itaconate and thus the role of non-derivatized itaconate needs to be scrutinized. …

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GLP-2 Is Locally Produced From Human Islets and Balances Inflammation Through an Inter-Islet-Immune Cell Crosstalk

Wei He, Osmond D. Rebello, Antonia Henne, Fabian Nikolka et autres

Glucagon-like peptide-1 (GLP-1) shows robust protective effects on β-cell survival and function and GLP-1 based therapies are successfully applied for type-2 diabetes (T2D) and obesity. Another cleavage product of pro-glucagon, Glucagon-like peptide-2 (GLP-2; both GLP-1 and GLP-2 are inactivated by DPP-4) has …

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