Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19
Fotios; https://orcid.org/0000-0002-1030-0635 Karagiannis, Konrad Peukert, Laura; https://orcid.org/0000-0001-8152-0611 Surace, Marcel Michla et autres
Anorexia and fasting are host adaptations to acute infection, inducing a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB) 1-6. However, whether ketogenesis metabolically influences the immune response in pulmonary infections remains unclear. Here we report impaired …
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