Accès ouvert déclaré
2016
article
Poster session 3Cell growth, differentiation and stem cells - Heart511The role of the endocannabinoid system in modelling muscular dystrophy cardiac disease with induced pluripotent stem cells.512An emerging role of T lymphocytes in cardiac regenerative processes in heart failure due to dilated cardiomyopathy513Canonical wnt signaling reverses the ‘aged/senescent’ human endogenous cardiac stem cell phenotype514Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes515Biocompatibility of mesenchymal stem cells with a spider silk matrix and its potential use as scaffold for cardiac tissue regeneration516A snapshot of genome-wide transcription in human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs)517Can NOS/sGC/cGK1 pathway trigger the differentiation and maturation of mouse embryonic stem cells (ESCs)?518Introduction of external Ik1 to human-induced pluripotent stem cell-derived cardiomyocytes via Ik1-expressing HEK29351
Aoife Gowran, T. G. Kulikova, FC Lewis, Gábor Földes, Lucı́a Fuentes, LE Viiri, Valentina Spinelli, Ambra Costa, Filippo Perbellini, C. Sid-Otmane, Nam Noortje Bax, Mari Pekkanen-Mattila, Concetta Schiano, Anna Chaloupka, Francesca Forini, Márta Sárközy, Sca De Jager, Tanja Vajen, Nadezhda Glezeva, H W Lee, А. С. Головкин, Tomáš Kučera, N. Musikhina, N. P Korzhenkov, Diana Munteanu, Rodrigo Garófallo Garcia, Ru Jing Ang, Shinichi Usui, Claire Jumeau, Mikael Åberg, Д А Костина, MM Brandt, Danina Muntean, D. P. Lindner, Rafael Sádaba, Barbara Szeiffová Bačová, A Nikolov, David Sedmera, V. V. Ryabov, FP Neto, Michael Lynch, Vincent Portero, Péter Kui, FC Howarth, A. Gualdoni, János Prorok, L Diolaiuti, František Vostárek, Marcus Wagner, Mark Abela, Clemens Nebert, Wu Xiang, Monika Kloza, A Maslenko, M. Grechanyk, Anirban Bhattachariya, Henning Morawietz, А. Г. Бабаева, S Sánchez, KA Krychtiuk, Susanna Fiorelli, Paul Rinne, David Gur, Thomas M. Hofbauer, Konstantinos Stellos, Olga Tsoref, Barbara Thaler, RA Fraga-Silva, WW Fuijkschot, MNS Shaaban, Claudia Matthaeus, Dorien Deluyker, Marina Scardigli, Alexandra Zahradnı́ková, Alejandro Domínguez, Д. С. Кондратьева, T Sosorburam, M Murarikova, Georg Daniel Duerr, Lucia Griecsová, В. І. Портніченко, Natalia Smolina, Oana Duicu, JM Elder, Tania Zaglia, Andrea Lorenzon, Celia Rupérez, Nadine Suffee, Claudio de Lucia, Adam Russell‐Hallinan, Ivan Menendez-Montes, Kapel'ko Vi, RW Emmens, O Hetman, Willem J. van der Laarse, Sergey Goncharov, Rui Adão, Barbara Huisamen, Oksana Sirenko, Isar Nassiri, Sumiya Tserendavaa, K Yushko, McConnell Martin, Carmen Falcone, Vera Vigorelli, Patrizia Nigro, Giulio Pompilio, О. В. Степанова, M. P. Valikhov, Samko An, V P Masenko, S. N. Тereschenko, Tze Shin Teoh, Eva Domenjo‐Vila, Thomas Theologou, Matt Field, Wael I. Awad, Mohammed Yasin, Bernardo Nadal‐Ginard, GM Ellison-Hughes, Nicola Hellen, Orsolya Vittay, Siân E. Harding, L Gómez-Cid, ME Fernandez-Santos, S Suárez-Sancho, V. Plasencia, Andreu M. Climent, Ricardo Sanz‐Ruiz, My Hedhammar, Felipe Atienza, Francisco Fernández‐Avilés, Mostafa Kiamehr, Mikko Oittinen, KM Viiri, Minna U. Kaikkonen, Katriina Aalto‐Setälä, Annunziatina Laurino, Laura Sartiani, Alessia Vona, Matteo Zanardelli, Elisabetta Cerbai, Paola Failli, MP. Hortigon-Vinagre, M Van Der Heyden, FL Burton, GL Smith, Steve P. Watson, Martina Scigliano, С. М. Ткач, Samha Alayoubi, CM Terracciano, HQ Ly, Arianna Mauretti, M.V.V. Marion, Mark C. van Turnhout, DWJ Van Der Schaft, CM Cecilia Sahlgren, Marie‐José Goumans, Hanna Vuorenpää, Kirsi Penttinen, Riina Sarkanen, Timo Ylikomi, Tuula Heinonen, Vincenzo Grimaldi, Maria Aprile, Roberta Esposito, Ciro Maiello, Andrea Soricelli, Vittorio Colantuoni, Veronica Costa, Alfredo Ciccodicola, C. Napoli, GC Rowe, Kathia M. Johnson, ZP Arany, Federica del Monte, Romina D’Aurizio, Claudia Kusmic, Giuseppina Nicolini, Mario Baumgart, Marco Groth, Nadia Ucciferri, Giorgio Iervasi, Letizia Pitto, Márton Pipicz, Renáta Gáspár, Andrea Siska, Imre Földesi, Katalin Kiss, P Bencsik, Thomas Thum, Sándor Bátkai, T. Csont, JJ Haan, Leontien Bosch, MAD Brans, SM Van De Weg, JC Deddens, SoJung Lee, JPG Sluijter, Gerard Pasterkamp, I. Werner, Delia Projahn, Martin Staudt, Adelina Curaj, T. T. Soenmez, Sakine Simsekyilmaz, Tilman M. Hackeng, Philipp von Hundelshausen, RR Koenen, Christian Weber, EA Liehn, Maria José Santos-Martínez, Carlos Alberto Hernández Medina, Kenneth McDonald, John F. Gilmer, Mark Ledwidge, SH Song, MY Lee, Moon Ho Park, JC Choi, JH Ahn, James Park, JH Oh, JH Choi, Hsin‐Chen Lee, KS Cha, TJ Hong, Igor Kudryavtsev, Anna Malashicheva, А. А. Shishkova, E. V. Zhiduleva, О. М. Моисеева, M. Bláha, Vojtěch Melenovský, Jan Pirk, Josef Kautzner, TI Petelina, LI Gapon, EA Gorbatenko, YV Potolinskaya, E. A. Arkhipova, К. С. Солоденкова, MA Osadchuk, MF Dutra, FCB Oliveira, MM Silva, DG Passos-Silva, Rita Gonçalves, RAS Santos, RF Da Silva, CM Gavrilescu, CM Paraschiv, P Manea, LC Strat, JMG Gomez, Daniela Merino, MA Hurle, JF Nistal, Antonio Aires, AL Cortajarena, Ana V. Villar, Joel Abramowitz, Lutz Birnbaumer, A. V. Gourine, Andrew Tinker, Masayuki Takamura, S Takashima, Oto Inoue, Hirofumi Misu, Tsuyoshi Takamura, Shuichi Kaneko, Tohira Alieva, Nathalie Mougenot, M Dufilho, Stéphane Hatem, Agneta Siegbahn, AS Kostina, VE Uspensky, OM Moiseeva, AA Kostareva, AB Malashicheva, CGM Van Dijk, Ihsan Chrifi, MC Verhaar, DJ Duncker, Chenxi Cheng, Adrian Sturza, Alexandra Petruş, L Kiss, István Baczkó, Norbert Jost, F Gotzhein, Jennifer Schön, Michael Schwarzl, Saba Hinrichs, Stefan Blankenberg, Uwe Völker, Elke Hammer, Dirk Westermann, Eduardo Martínez‐Martínez, Vanessa Arrieta, Amaya Fernández‐Celis, L Jimenez-Alfaro, A. Melero, V Alvarez-Asiain, Victoria Cachofeiro, Natalia López‐Andrés, Narcis Tribulová, Gerd Wallukat, Vladimír Knezl, Jana Radošinská, Miroslav Barančı́k, I. Tsinlikov, I. Tsinlikova, G. Nicoloff, Alexander Blazhev, Zivorad Pesevski, Alena Kvasilová, Tereza Stopkova, Allen E. Eckhardt, C M Buffinton, O Nanka, М. А. Керчева, Т. Е. Суслова, А. М. Гусакова, T. R. Ryabova, Valentin Markov, Р. С. Карпов, Henning Seemann, T. O. Alcantara, SG Fonseca, Javier Barallobre‐Barreiro, Marika Fava, Ferheen Baig, Xiaoqin Yin, Hassan Albadawi, Marjan Jahangiri, Julianne Stoughton, Manuel Mayr, SP Podliesna, CCV Veerman, AOV Verkerk, MK Klerk, EML Lodder, IM Mengarelli, CRB Bezzina, CAR Remme, Hedvig Takács, Alexandra Polyák, Nikolett Morvay, István Leprán, László Tiszlavicz, Nikoletta Nagy, András Farkas, Tamás Forster, AS Farkas, Priyamvada Jayaprakash, Kalpaj R. Parekh, Zannatul Ferdous, Murat Öz, H Dobrzynski, Thomas E. Adrian, Sara Landi, Mattia Bonzanni, Alwyn D’Souza, Mark R. Boyett, Annalisa Bucchi, Mirko Baruscotti, Dario DiFrancesco, Andrea Barbuti, Kinga Oravecz, Tamás Hézső, Jouko Levijoki, Piero Pollesello, Tuula Koskelainen, Leena Otsomaa, J. P. Papp, Andrea Tóth, Károly Acsai, Luciana Dini, Luca Mazzoni, A. Mugelli, Jarmila Svatunkova, Christian Deffge, Claxton Baer, Sönke Weinert, RC Braun-Dullaeus, Joerg Herold, AC Cassar, GZ Zahra, E Pllaha, PD Dingli, SM Montefort, R. G. Xuereb, Thomas Aschacher, Berith Messner, Eva Eichmair, Werner Möhl, Bettina Reglin, Wenchao Rong, Bianca Nitzsche, Martin Maibier, Pedro Guimarães, Alessandra Ruggeri, TW Secomb, A. R. Pries, Marta Baranowska‐Kuczko, Olga Karpińska, Magdalena Kusaczuk, Barbara Malinowska, H. Kozłowska, Nadiia Demikhova, L Vynnychenko, O. V. Prykhodko, N Grechanyk, A. Kuryata, KA Cottrill, Lei Du, H.M. Bjorck, S. Maleki, Anders Franco‐Cereceda, S.‐F. CHAN, Sindy Giebe, Natalia Cockcroft, Katherine Hewitt, Melanie Brux, Coy Brunßen, А. А. Тарасов, S Davidov, E. A. Reznikova, A Tapia Abellan, D Angosto Bazarra, P Pelegrin Vivancos, Sylvie Garcia, SP Kastl, Thomas Pongratz, Georg Goliasch, Laurie E. Gaspar, Gerald Maurer, Kurt Huber, Elisabeth Dostal, Stephan Pfaffenberger, Stanislav Oravec, Johann Wojta, Speidl Ws, И. В. Осипова, I Sopotova, Sonia Eligini, Nicola Cosentino, Giancarlo Marenzi, Elena Tremoli, Martina Rami, Larisa Ring, Sabine Steffens, Oren M. Gur, Suat Gurkan, Andreas Mangold, Thomas Scherz, Adelheid Panzenboeck, Nikolai Staier, Hamidreza Heidari, Jennifer Mueller, Iréne Lang, И. В. Осипова, Aikaterini Gatsiou, K. Stamatelopoulos, Ljubica Perisic, D. I. JOHN, FF Lunella, Ulf Hedin, Andreas M. Zeiher, Stefanie Dimmeler, Rita Moure, Grecia M. Marrón-Liñares, G Aldama, João Vinícius Salgado, Ramón Calviño, Marta Tomàs, Germán Bou, Neftalí Vázquez, M Hermida-Prieto, JM Vázquez-Rodríguez, Natalie Landa, David Kain, Dalia Tyomkin, Anna L. David, Jonathan Leor, PJ Hohensinner, J Baumgartner, Nagyung Baik, LA Miles, Hugo Seeman, Fabrizio Montecucco, AR Da Silva, FP Costa-Fraga, L. Anguenot, FP Mach, Nikolaos Stergiopulos, Koba Kupreishvili, ABA Vonk, YM Smulders, VWM Van Hinsbergh, Wim Stooker, MM Ashmawy, MA Salama, MZ Elamrosy, R Juettner, Fritz G. Rathjen, Virginie Bito, Claudia Crocini, Cecilia Ferrantini, Tecla Gabbrielli, L. Silvestri, Raffaele Coppini, Chiara Tesi, Corrado Poggesi, Francesco S. Pavone, Leonardo Sacconi, Katarina Macková, Ivan Zahradnı́k, Irene Dı́az, Elisa Pedro, Abdelkrim Hmadcha, E Calderon Sanchez, Jean‐Pierre Bénitah, Ana M. Gómez, Tarik Smani, Antonio Ordóñez, SA Afanasiev, М С Егорова, S. E. Popov, Xu Cheng, Slávka Čarnická, D Pancza, M Jasova, I Kancirova, Miroslav Ferko, T Ravíngerová, S T Wu, Michael Schneider, Vanessa Marggraf, Luise Verfuerth, Silvia Frede, Olaf Boehm, Oliver Dewald, Georg Baumgarten, SC Kim, Veronika Farkašová, I Gablovsky, Iveta Bernátová, V. I. Nosar, Alla G. Portnychenko, T. Drevytska, Man'kovs'ka Im, Vladimir Gogvadze, Thomas Sejersen, Anna Kostareva, Alon Wolf, Andreea Privistirescu, P. O' Gara, JL Sanchez-Alonso, AR Lyon, Valentina Prando, Nicola Pianca, Francesca Lo Verso, Giulia Milan, Paola Pesce, Maria Teresa Sandri, M. Mongillo, Giorgia Beffagna, Guy Poloni, Emanuela Dazzo, Patrizia Sabatelli, Roberto Doliana, Roman Polishchuk, Daniela Carnevale, Giuseppe Lembo, Paolo Bonaldo, Paola Braghetta, Alessandra Rampazzo, Mitchell S. Cairo, Mercedes Giralt, Francesc Villarroya, Anna Planavila, P. Stefan Biesbroek, RWE Emmens, A. Wall, AC Van Rossum, JWM Niessen, T Moor Morris, Gilles Dilanian, P. Farahmand, Michel Pucéat, Giuditta Gambino, Laura Petraglia, Andrew E. H. Elia, Klara Komici, Grazia Daniela Femminella, ML D'amico, Gennaro Pagano, Alessandro Cannavò, Daniela Liccardo, WJ Koch, Maria Nolano, Dario Leosco, Nicola Ferrara, Giuseppe Rengo, Roisín Neary, Liam Shiels, John A. Baugh, Bridgitte E. Palacios, Bertha Angélica Bonilla Escobar, A Herranz Alonso, Gabriela Guzmán, Jesús Ruı́z-Cabello, LJ Jiménez-Borreguero, Silvia Martı́n-Puig, VL Lakomkin, Е.В. Лукошкова, AA Abramov, В. В. Грамович, О. Н. Выборов, VV Ermishkin, N.A. Undrovinas Undrovinas, VP Shirinsky, BJ Smilde, G Fong Hing, D. Wouters, Sacha Zeerleder, Jean‐Luc Murk, SM Van Ham, Stéphane Heymans, PAJ Krijnen, O Krakhmalova, Duncan van Groen, SJP Bogaards, Ingrid Schalij, GV Portnichenko, Tumanovs'ka Lv, YV Goshovska, TU Lapikova-Bryhinska, VS Nagibin, Victor Dosenko, Pedro Mendes‐Ferreira, C. Maia-Rocha, Diana Santos‐Ribeiro, François Potus, Sandra Breuils‐Bonnet, S. Provencher, Sébastien Bonnet, MT Rademaker, Adelino Leite‐Moreira, Carmen Brás‐Silva, José Maria de Andrade Lopes, O. Kuryata, T Lusynets, I Alikulov, Malika Nourddine, L. Azzouzi, Rachida Habbal, ZORIGO Shagdar, MUNKHZ Malchinkhuu, MUNLHZ Malchinkhuu, Susan F. Koval, Т. Г. Старченко, Laura Mouriño-Álvarez, Laura Gonzalez‐Calero, Tamara Sastre-Oliva, J. Santos López, Jessica Vázquez, Luís M. Ruilope, Fernando de la Cuesta, MG Barderas, S. Bozzini, Angela D’Angelo, Gabriele Pelissero
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16Institutions déclarées
7Pays d’affiliation déclarés
Rattachement africain : gb, it, ru, es, fi, us, se.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Muscular Dystrophy (MD) is an umbrella term for genetic disorders affecting skeletal and cardiac muscle which arise due to abnormalities in the dystrophin gene.Underlying dystrophin defects cause metabolic and structural abnormalities in cardiomyocytes (CMs) which in turn become predisposed to ectopic cell death and fibro-fatty replacement.The Endogenous Cannabinoid System (ECS) is a lipid signalling network present in the cardiovascular system and comprises G-protein coupled receptors (CBR1 and CBR2), endogenous ligands (anandamide and 2-arachidonoylglycerol) and regulatory proteins (fatty acid amide hydrolase and monoacylglycerol lipase).The ECS has an emerging function in stem cell survival and differentiation, MD skeletal muscle pathology, and cardiovascular diseases in general.Induced Pluripotent Stem Cell (iPSC) technology permits the reprogramming of somatic cells (e.g.fibroblasts) into pluripotent stem cells, which can be differentiated into cells from all three germ layers including CMs.In the present study we provide evidence that the ECS is involved in somatic cell reprogramming.Specifically, the CBR1 antagonist AM251 prevented the formation of iPSC colonies (p≤0.05, vs. control conditions, Newman-Keuls multiple comparison test, n=3).CMs derived from MD patients' iPSCs (MD-CMs) displayed disease hallmarks such as lack of dystrophin expression, increased expression of Nup153 (a cardiomyopathy-associated protein; p=0.0009, vs. healthy CMs, Student's unpaired t test, n=3) and increased CM cell death (p≤0.0001, vs. healthy CMs, Student's unpaired t test, n=3).Furthermore, we also provide evidence that the ECS is present in iPSCs and becomes dysregulated in MD-CMs.Our results highlight the dual functionality of the ECS in cell reprogramming and MD cardiac pathology which is of interest to cardiac disease modelling and novel drug discovery.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Poster session 3Cell growth, differentiation and stem cells - Heart511The role of the endocannabinoid system in modelling muscular dystrophy cardiac disease with induced pluripotent stem cells.512An emerging role of T lymphocytes in cardiac regenerative processes in heart failure due to dilated cardiomyopathy513Canonical wnt signaling reverses the ‘aged/senescent’ human endogenous cardiac stem cell phenotype514Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes515Biocompatibility of mesenchymal stem cells with a spider silk matrix and its potential use as scaffold for cardiac tissue regeneration516A snapshot of genome-wide transcription in human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs)517Can NOS/sGC/cGK1 pathway trigger the differentiation and maturation of mouse embryonic stem cells (ESCs)?518Introduction of external Ik1 to human-induced pluripotent stem cell-derived cardiomyocytes via Ik1-expressing HEK29351
- Date Crossref
- 01/07/2016
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Tissue Engineering and Regenerative MedicineElectrospun Nanofibers in Biomedical ApplicationsPluripotent Stem Cells Research