Mirko Baruscotti

Hcn4-deficient zebrafish embryos develop a normal left‒right axis

Alberto Diana, Andrea Masseroni, Adèle Faucherre, Chris Jopling et autres

Background Left‒right (LR) asymmetry is a well-conserved feature of the Vertebrate body plan and is essential for the correct positioning and morphogenesis of visceral organs. While asymmetric Nodal signaling established by the LR organizer (LRO) is widely accepted as a core mechanism …

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The Binding of Fibroblast Growth Factor 23 ( FGF23 ) to FGF Receptor‐ αKlotho Complex Increases Sinoatrial Electrical Activity

Giorgia Bertoli, Patrizia Benzoni, Serena Canzolino, David Molla et autres

ABSTRACT Aim This study aims to investigate whether the Fibroblast Growth Factor 23 (FGF23) modulates the electrical activity of sinoatrial (SAN) cells. The canonical function of FGF23 is to regulate body phosphorus and calcium homeostasis by activating the FGF1 receptors (FGFR1)/α‐Klotho complex …

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Camizestrant-induced heart rate reduction is mediated via a sinoatrial node pacemaker channel mechanism

Andrew Hall, Saïd El-Haou, Inmaculada Concepción Villar, David Molla et autres

Camizestrant, a next-generation selective estrogen receptor (ER) degrader and complete ER antagonist, has been associated with a reversible dose- and time-dependent heart rate (HR) reduction in clinical studies. This nonclinical investigation aimed to understand the mechanism of camizestrant-induced HR reduction. The effects …

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Traditional Chinese medicine for long COVID-19: the potential roles of immunity remodeling

Qianru Zhao, Annalisa Bucchi, Xinyu Duan, Zhihua Yang et autres

Given that the immunity imbalance in patients with Long COVID-19 (LC) may pose a significant global health and economic post-pandemic burden, there is an emergent need to identify therapeutic targets and treatment options. Traditional Chinese medicine (TCM), as an evidence-based therapeutic approach, …

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Abstract Fri093: Hypokalemia and SCN5A S805L mutation concur to Brugada event

Martina Arici, Anthony Frosio, Procolo Marchese, Giorgia Bertoli et autres

Brugada Syndrome (BrS) is a genetic disease associated with ventricular arrhythmias and is one of the causes of sudden cardiac death. In particular, dysfunctional cardiac Na + channels (SCN5A) represent the only mechanism supporting the autosomal dominant inheritance. A proband without previous …

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Abstract Thu073: HCN4 misregulation affects the early differentiation process of mouse embryonal stem cell

Martina Arici, Valentina Pastori, Patrizia Benzoni, Roberta Pensotti et autres

Alterations of bioelectrical signals at early embryonic stages may cause heterotaxia. It has been shown that the lack of the pacemaker channel HCN4 at the very early stage of Xenopus laevis development induces heterotaxia and malformed hearts. This project aims to better …

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Hypokalaemia and bradycardia unmask the loss-of-function phenotype of a Brugada Syndrome SCN5A mutation

Anthony Frosio, Procolo Marchese, Giorgia Bertoli, David Molla et autres

AIMS: Loss-of-function (LOF) mutations of the cardiac Na+ channel (SCN5A) are causatively associated with the Brugada Syndrome (BrS). However, the onset of Ventricular Fibrillation (VF) is a rare event, and critical factors favouring the pathological phenotype remain often elusive. This study explores …

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Identification of Senkyunolide I as a novel modulator of hepatic steatosis and PPARα signaling in zebrafish and hamster models

Qingquan Li, Jian Sheng, Mirko Baruscotti, Zhenjie Liu et autres

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NOD-1 activation increases the spontaneous activity and the I(f) current of murine sinoatrial node cells

Serena Canzolino, Giorgia Bertoli, Samira Bakhouba, David Molla et autres

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A gain of function mutation in PITX2c gene linked to atrial fibrillation alters mitochondrial function and membrane excitability

Patrizia Benzoni, Lorenzo Da Dalt, Alessandro Cospito, Vera Popolizio et autres

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In-vitro studies of the NaV1.5 S805L Brugada mutation: The resting cell voltage is a critical element in determining the pathological or physiological phenotype of the current

David Molla, Anthony Frosio, Giorgia Bertoli, Chiara Piantoni et autres

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Striatin knock out induces a gain of function of INa and impaired Ca2+ handling in mESC ‐derived cardiomyocytes

Patrizia Benzoni, Martina Arici, Federica Giannetti, Alessandro Cospito et autres

Abstract Aim Striatin (Strn) is a scaffold protein expressed in cardiomyocytes (CMs) and alteration of its expression are described in various cardiac diseases. However, the alteration underlying its pathogenicity have been poorly investigated. Methods We studied the role(s) of cardiac Strn gene …

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