Eva Domenjo‐Vila

I am me and my circumstance – Context dictates the outcome of IL-1 signaling in and around T cells

Eva Domenjo‐Vila, Marc A. Gavin, Martin Prlic

Afrique du Sud, us (code pays fourni par la source)

HSV-2 Infection Induces Lasting Transcriptional and Functional Changes in Vaginal Tissue NK Cells 2258179

Sarah Vick, Eva Domenjo‐Vila, Lakshmi Warrier, Jennifer M. Lund

Abstract Introduction Mucosal immunity in the vaginal tract (VT) remains poorly defined despite its essential role in defense against sexually transmitted infections. Natural killer (NK) cells are critical for antiviral control, and increasing evidence indicates that they can acquire adaptive-like features following …

Afrique du Sud, us (code pays fourni par la source)

Personalized tumor-loaded monocyte-derived dendritic cell vaccination in combination with atezolizumab as maintenance treatment in extensive-stage small cell lung cancer (ES-SCLC): phase Ib-II VENEZOLUNG trial

María González‐Cao, Marta Sisteré‐Oró, Teresa Morán, Noemi Reguart et autres

Background Despite the incorporation of atezolizumab, an anti-programmed death-ligand 1 (PD-L1) antibody, into first-line chemotherapy regimen, survival in patients with extensive-stage small cell lung cancer (ES-SCLC) remains poor. Given the role of dendritic cells (DCs) in modulating responses to anti-programmed cell death …

es (code pays fourni par la source)

Tissue-specific adaptation of human T cells is preserved during tissue inflammation

Nicole B. Potchen, Hugh R. MacMillan, Eva Domenjo‐Vila, A Konecny et autres

Summary T cells play an essential role in protecting tissues against pathogens and regulating tissue homeostasis. Previous studies highlight that T cells display tissue-specific phenotypic and functional properties, suggesting that T cells adapt to their local environment. Whether inflammation disrupts tissue-specific T …

us (code pays fourni par la source)

An at-home blood collection device for remote immune monitoring by high-parameter flow cytometry

A Konecny, Fang Yun Lim, Eva Domenjo‐Vila, Erika A. Lovas et autres

At-home blood collection devices (ABCDs) can facilitate study participation for remote and rural cohorts. Previous studies used ABCDs to interrogate samples by proteomics and sequencing approaches. We wanted to address the question of whether this approach could be used to assess live …

us (code pays fourni par la source)

T cells retain the ability to mediate tissue repair in severely inflamed human mucosa 4217

Nicole B. Potchen, A Konecny, Eva Domenjo‐Vila, Alexis K Taber et autres

Abstract Description T cells play a key role in driving as well as resolving tissue inflammation. Whether the compositional and functional properties of the T cell compartment change as tissues progress from a mildly to severely inflamed state is still poorly understood. …

Afrique du Sud, us (code pays fourni par la source)

Mucosal tissue NK cells directly mediate tissue protection and repair during infection

Sarah C. Vick, Eva Domenjo‐Vila, Marie Frutoso, Raisa A. Glabman et autres

Preserving barrier integrity is of great importance in mucosal tissues while simultaneously defending against inflammatory threats and exposures to pathogens. NK cells at barrier sites are essential for viral control during infections such as herpes simplex virus 2 (HSV-2) but must also …

us, Afrique du Sud (code pays fourni par la source)

Decoding mucosal immunity: A unique natural killer cell profile in vaginal tissue.

Sarah C. Vick, Eva Domenjo‐Vila, Sean M. Hughes, Anna C. Kirby et autres

Abstract Mucosal immunity in the vaginal tract (VT) remains poorly characterized despite its critical role in protecting from sexually transmitted infections. NK cells, critical for resolving infections, are found in the VT in significant numbers yet it is unknown how the immune …

Afrique du Sud, us (code pays fourni par la source)

A Noninvasive Method to Sample Immune Cells in the Lower Female Genital Tract Using Menstrual Discs

MP Peters, Eva Domenjo‐Vila, Marc R. J. Carlson, Blair Armistead et autres

T cells in the human female genital tract (FGT) are key mediators of susceptibility to and protection from infection, including HIV and other sexually transmitted infections. There is a critical need for increased understanding of the distribution and activation of T cell …

us (code pays fourni par la source)

Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation

Valentina Casella, Eva Domenjo‐Vila, Anna Esteve‐Codina, Mireia Pedragosa et autres

Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that contribute to these fates are described, the critical control points and the mechanisms that underlie infection fate regulation are incompletely understood. Using the …

es, au, ru (code pays fourni par la source)

A non-invasive method to sample immune cells in the lower female genital tract using menstrual discs

MP Peters, Eva Domenjo‐Vila, Marc R. J. Carlson, Blair Armistead et autres

ABSTRACT T cells in the human female genital tract (FGT) 2 are key mediators of susceptibility to and protection from infection, including HIV and other sexually transmitted infections. There is a critical need for increased understanding of the distribution and activation of …

us, Afrique du Sud (code pays fourni par la source)

XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

Eva Domenjo‐Vila, Valentina Casella, Ryutaro Iwabuchi, Even Fossum et autres

d XCR1+ DCs are more functional and less prone to LCMV infection than SIRPa+ DCs d Expanding XCR1+ DCs via Flt3L or delivering XCR1-targeting Ag improve virus control d Anti-PD-L1 treatment increases XCR1+ DC numbers and IL-12 production d XCR1+ DCs promote …

es, jp, no, ru (code pays fourni par la source)