Thomas Edward Adrian

Mechanisms and biomarkers for musculoskeletal signs and symptoms in patients treated with aromatase inhibitors: A comprehensive systematic review

Noora Jatan, Sami Talo, Aida J. Azar, Thomas Edward Adrian et autres

BACKGROUND: Aromatase inhibitors anastrozole and letrozole (non-steroidal, reversible), and exemestane (steroidal, irreversible) are approved standard therapies (Food and Drug Administration) for hormone receptor-positive breast cancer. Their use is limited by Aromatase Inhibitor-induced Musculoskeletal Signs and Symptoms (AIMSS). METHODS: Articles on AIMSS mechanisms …

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The Effects of Frondanol, a Non-Polar Extract of the Atlantic Sea Cucumber, in Colon Cancer Cells

Hardik Ghelani, Hala Altaher, Hadil Sarsour, Marah Tabbal et autres

Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. The search for effective, new antineoplastic drugs with fewer side effects for the treatment of CRC continues, with marine-derived compounds emerging as promising candidates. Objectives: This study investigates the …

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Anti-inflammatory effects of Frondanol, a nutraceutical extract from Cucumaria frondosa, via modulation of NF-κB and MAPK pathways in LPS-induced RAW 264.7 cells

Hardik Ghelani, Kerat Hanspal, Lana Talo, Sami Talo et autres

Introduction Frondanol, a non-polar lipid extract derived from the edible sea cucumber Cucumaria frondosa, has shown promising anti-inflammatory properties. Methods This study investigated its molecular mechanisms in modulating inflammation using lipopolysaccharide (LPS)-stimulated RAW 264.7 murine macrophages. Results Frondanol was found to be …

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P482: Youth Council for Breast Health: A BCYW Foundation’s Global Initiative Empowering Young Women on Campuses to Promote Breast Health Awareness for a Breast Cancer-free Future

Rakesh Kumar, Sarika Saini, M.J. Vrancken Peeter, K. Amulya et autres

Anti-Inflammatory Effects of Bioactive Compounds from Seaweeds, Bryozoans, Jellyfish, Shellfish and Peanut Worms

Md Khursheed, Hardik Ghelani, Reem Kais Jan, Thomas Edward Adrian

Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic inflammation plays an important role in the pathogenesis of a variety of diseases. Multiple anti-inflammatory drugs are currently …

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Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies

Vishnu Raj, Balaji Venkataraman, Shreesh Kumar Ojha, Saeeda Almarzooqi et autres

Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses. Inflammatory bowel diseases that comprise Crohn's disease (CD) and ulcerative …

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Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation

Balaji Venkataraman, Saeeda Almarzooqi, Vishnu Raj, Bhoomendra A. Bhongade et autres

Inflammatory bowel disease, comprising Crohn's disease (CD) and ulcerative colitis (UC), is often debilitating. The disease etiology is multifactorial, involving genetic susceptibility, microbial dysregulation, abnormal immune activation, and environmental factors. Currently, available drug therapies are associated with adverse effects when used long-term. …

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Using publicly available datasets to identify population-based transcriptomic landscape contributing to the aggressiveness of breast cancer in young women

Marah Tabbal, Mahmood Yaseen Hachim, Reem Kais Jan, Thomas Edward Adrian

Introduction: Although the risk of breast cancer increases with advancing age, some regions have larger number of young breast cancer patients (≤45 years-old), such as the Middle East, Eastern Asia, and North Africa, with more aggressive and poorly differentiated tumors. We aimed …

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Supplementary Material for: Hepatic fibrosis evaluated in patients with type 2 diabetes with and without chronic kidney disease

Thomas Edward Adrian, Mads Hornum, Knop F.K, Karl Bang Christensen et autres

Background. Non-alcoholic fatty liver disease (NAFLD), and particularly liver fibrosis, has been suggested as a risk factor of chronic kidney disease (CKD). Given that NAFLD affects every fourth person globally, better insight is needed. Our aim was to investigate the association between …

β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways

Saeeda Almarzooqi, Balaji Venkataraman, Vishnu Raj, Sultan Ali Abdulla Alkuwaiti et autres

Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that include Crohn's disease (CD) and ulcerative colitis (UC). The incidence of IBD is rising globally. However, the etiology of IBD is complex and governed by multiple factors. The current clinical treatment for IBD …

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Study protocol for a pilot randomized, double-blind, placebo-controlled trial to investigate the anti-inflammatory effects of Frondanol in adults with inflammatory bowel disease

Hardik Ghelani, Thomas Edward Adrian, Samuel B. Ho, Jamil Akhras et autres

Introduction: has been reported to possess potent anti-inflammatory effects, likely mediated by the inhibition of 5-lipoxygenase and 12-lipoxygenase pathways, whilst showing no signs of toxicity. The potent anti-inflammatory effects of Frondanol in a mouse model of IBD provide encouragement for investigating its …

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Anti-Inflammatory Effects of Compounds from Echinoderms

Hardik Ghelani, Md Khursheed, Thomas Edward Adrian, Reem Kais Jan

Chronic inflammation can extensively burden a healthcare system. Several synthetic anti-inflammatory drugs are currently available in clinical practice, but each has its own side effect profile. The planet is gifted with vast and diverse oceans, which provide a treasure of bioactive compounds, …

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