Luise Verfuerth

CpG postconditioning after reperfused myocardial infarction is associated with modulated inflammation, less apoptosis, and better left ventricular function

Georg Daniel Duerr, Shuijing Wu, Max Lukas Schneider, Vanessa Marggraf et autres

Cytosine-phosphate-guanine (CpG) postconditioning seems to mediate inflammation via Toll-like receptor-1 and Toll-like receptor-9 signaling. Enhanced cytokine and chemokine expressions are partly attenuated by IL-10 and matrix metalloproteinase-8 (MMP8) induction, being associated with lower macrophage infiltration and M1-monocyte differentiation. Furthermore, switch from α- …

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Periconditioning with CpG-Containing TLR9 Ligand 1668-Thioate Ameliorates Left Ventricular Function via Modulation of Inflammation and Remodeling Resulting in Less Fibrosis in a Mouse Model of Reperfused Myocardial Infarction

Georg Daniel Dürr, Markus Peter Schneider, Vanessa Marggraf, Luise Verfuerth et autres

All articles of this category Objectives: It has been shown that postconditioning (PCon) is able to attenuate inflammation and fibrosis in myocardial infarction. Aim of this study was to investigate whether PCon with the synthetic CpG-containing TLR9 ligand 1668-thioate (CpG) can modulate …

CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion

Georg Daniel Duerr, Andreas Feißt, Katharina Halbach, Luise Verfuerth et autres

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P87Deleterious effects of FAAH-deficiency on development of ischemic cardiomyopathy in mice

Luise Verfuerth, Peter Zimmermann, Andreas Zimmer, Beat Lutz et autres

Introduction: Ischemic cardiomyopathy is associated with repetitive ischemia and reperfusion (I/R), which leads to inflammatory reaction and left ventricular (LV) dysfunction. Animal studies provided evidence for cardioprotective effects of the endocannabinoid system after myocardial ischemia including modulation of cardiomyocyte adaptation, inflammation and …

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Poster session 3Cell growth, differentiation and stem cells - Heart511The role of the endocannabinoid system in modelling muscular dystrophy cardiac disease with induced pluripotent stem cells.512An emerging role of T lymphocytes in cardiac regenerative processes in heart failure due to dilated cardiomyopathy513Canonical wnt signaling reverses the ‘aged/senescent’ human endogenous cardiac stem cell phenotype514Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes515Biocompatibility of mesenchymal stem cells with a spider silk matrix and its potential use as scaffold for cardiac tissue regeneration516A snapshot of genome-wide transcription in human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs)517Can NOS/sGC/cGK1 pathway trigger the differentiation and maturation of mouse embryonic stem cells (ESCs)?518Introduction of external Ik1 to human-induced pluripotent stem cell-derived cardiomyocytes via Ik1-expressing HEK29351

Aoife Gowran, T. G. Kulikova, FC Lewis, Gábor Földes et autres

Muscular Dystrophy (MD) is an umbrella term for genetic disorders affecting skeletal and cardiac muscle which arise due to abnormalities in the dystrophin gene.Underlying dystrophin defects cause metabolic and structural abnormalities in cardiomyocytes (CMs) which in turn become predisposed to ectopic cell …

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Postconditioning with CpG-Containing TLR9 Ligand 1668-Thioate Attenuates Inflammatory Response and Remodeling Leading to Less Fibrosis and Better Left Ventricular Function in Murine Myocardial Infarction

Georg Daniel Duerr, Shih‐Ni Wu, Markus Peter Schneider, Vanessa Marggraf et autres

Objectives: Development of ischemic cardiomyopathy has been associated with inflammation and toll-like receptor (TLR)-signaling. It has been shown that post-conditioning (PCon) is able to attenuate inflammation and fibrosis in myocardial infarction. Here, we investigated whether PCon with the synthetic CpG-containing TLR9 ligand …

Metallothioneins 1 and 2 Modulate Inflammation and Support Remodeling in Ischemic Cardiomyopathy in Mice

Georg Daniel Duerr, Daniela Dewald, Eva Janine Schmitz, Luise Verfuerth et autres

Aims. Repetitive brief ischemia and reperfusion (I/R) is associated with left ventricular dysfunction during development of ischemic cardiomyopathy. We investigated the role of zinc-donor proteins metallothionein MT1 and MT2 in a closed-chest murine model of I/R. Methods. Daily 15-minute LAD-occlusion was performed …

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