Andreea I. Privistirescu

Methylene blue alleviates endothelial dysfunction and reduces oxidative stress in aortas from diabetic rats

Andreea I. Privistirescu, Alexandra Christa Sima, Oana Duicu, Romulus Zorin Timar et autres

Endothelial dysfunction and the related increase in reactive oxygen species (ROS) production are important events in the pathophysiology of diabetes mellitus (DM). Methylene blue (MB) has been systematically investigated for its protective effects against refractory hypotension and mitochondrial dysfunction. We have previously …

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Methylene blue improves mitochondrial respiration and decreases oxidative stress in a substrate-dependent manner in diabetic rat hearts

Oana Duicu, Andreea I. Privistirescu, Adrian Wolf, Alexandra Petruş et autres

Diabetic cardiomyopathy has been systematically associated with compromised mitochondrial energetics and increased generation of reactive oxygen species (ROS) that underlie its progression to heart failure. Methylene blue is a redox drug with reported protective effects mainly on brain mitochondria. The purpose of …

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The effect of purinergic signaling via the P2Y11 receptor on vascular function in a rat model of acute inflammation

Maria D. Dănilă, Andreea I. Privistirescu, Oana Duicu, Corina Rațiu et autres

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Poster session 3Cell growth, differentiation and stem cells - Heart511The role of the endocannabinoid system in modelling muscular dystrophy cardiac disease with induced pluripotent stem cells.512An emerging role of T lymphocytes in cardiac regenerative processes in heart failure due to dilated cardiomyopathy513Canonical wnt signaling reverses the ‘aged/senescent’ human endogenous cardiac stem cell phenotype514Hippo signalling modulates survival of human induced pluripotent stem cell-derived cardiomyocytes515Biocompatibility of mesenchymal stem cells with a spider silk matrix and its potential use as scaffold for cardiac tissue regeneration516A snapshot of genome-wide transcription in human induced pluripotent stem cell-derived hepatocyte-like cells (iPSC-HLCs)517Can NOS/sGC/cGK1 pathway trigger the differentiation and maturation of mouse embryonic stem cells (ESCs)?518Introduction of external Ik1 to human-induced pluripotent stem cell-derived cardiomyocytes via Ik1-expressing HEK29351

Aoife Gowran, T. G. Kulikova, FC Lewis, Gábor Földes et autres

Muscular Dystrophy (MD) is an umbrella term for genetic disorders affecting skeletal and cardiac muscle which arise due to abnormalities in the dystrophin gene.Underlying dystrophin defects cause metabolic and structural abnormalities in cardiomyocytes (CMs) which in turn become predisposed to ectopic cell …

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BIOENERGETIC CHARACTERIZATION OF H9C2 CELLS USING THE EXTRACELLULAR FLUX ANALYZER.

Ileana Scurtu, Adrian Sturza, Ioanna Zinuca Pavel, Roxana Popescu et autres

UNLABELLED: The aim of the present work was to standardize the working methodology for assessing the bioenergetic profile of H9c2 cardiomyoblasts cells, with reference to the optimization of cell seeding number and the establishment of favorable concentrations for the classic modulators of …

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Acute inhibition of monoamine oxidase and ischemic preconditioning in isolated rat hearts: interference with postischemic functional recovery but no effect on infarct size reduction

Maria D. Dănilă, Andreea I. Privistirescu, Silvia Nicoleta Mirică, Adrian Sturza et autres

Monoamine oxidases (MAOs) have recently emerged as important mitochondrial sources of oxidative stress in the cardiovascular system. Generation of reactive oxygen species during the brief episodes of ischemic preconditioning (IPC) is responsible for the cardioprotection at reperfusion. The aim of this study …

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DECREASED RESPIRATORY FUNCTION IN LIVER MITOCHONDRIA ISOLATED FROM HEALTY OLD RATS

Ioana Mihaela Citu, Viorica Kerti, Oana Duicu, Andreea I. Privistirescu et autres

Mitochondrion dysfunction has been constantly associated with ageing yet a significant variation across animal species and investigated tissues has been reported. We have previously demonstrated that healthy ageing is associated with impairment in heart mitochondria function. The purpose of the present study …

Reduction of Rage Expression by Vitamin D in Isolated Diabetic Rat Aortas

Adrian Sturza, Oana Duicu, Adrian Văduva, Lavinia Noveanu et autres

ADRIAN STURZA1,2, OANA DUICU1,2, ADRIAN VADUVA3, LAVINIA NOVEANU1,2, MARIA DANILA1,2, ANDREEA PRIVISTIRESCU1,2, ROMULUS TIMAR4, DANINA MUNTEAN1,2*, MIRCEA MUNTEANU4 1 “Victor Babes” University of Medicine and Pharmacy, Faculty of Medicine, Department of Pathophysiology, 2 Eftimie Murgu Sq., 300041, Timisoara, Romania 2 “Victor Babes” …

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Morphologic, Immunophenotypic and Bioenergetic Characterization of a Human Dermal Fibroblast Cell Line

Ioana Zinuca Pavel, Oana Duicu, Florina Maria Bojin, Andreea I. Privistirescu et autres

Background In the past years, ultraviolet-B (UVB)-induced morphological changes in cultured fibroblasts have been systematically studied in relation with photoprotective strategies. The present study was aimed at providing a comprehensive characterization of a human dermal fibroblast cell line, HDFa, in terms of: …

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Morphologic, Immunophenotypic and Bioenergetic Characterization of a Human Dermal Fibroblast Cell Line

Ioana Zinuca Pavel, Oana Duicu, Florina Maria Bojin, Andreea I. Privistirescu et autres

Background In the past years, ultraviolet-B (UVB)-induced morphological changes in cultured fibroblasts have been systematically studied in relation with photoprotective strategies. The present study was aimed at providing a comprehensive characterization of a human dermal fibroblast cell line, HDFa, in terms of: …

P151Cardioprotection by pharmacological agents targeting mitochondria is preserved in isolated aged rat hearts

Danina Mirela Muntean, OM Duicu, Andreea I. Privistirescu, MD Danila et autres

Whether cardioprotective strategies are still effective in elderly is a matter of debate. The present study was purported to assess the persistence of the protective effects of pharmacological agents targeting mitochondria in old Sprague-Dawley rats. Methods. To this aim isolated hearts from …

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P165Magnesium orotate in high concentration elicits cardioprotection via modulation of mitochondrial functions

Oana Duicu, Anikó Görbe, Andreea I. Privistirescu, Nicoleta Miricä et autres

Modulation of mitochondrial function in the settings of ischemia/reperfusion (I/R) injury represents a major therapeutic target of pharmacological agents able to reduce the cell death at reperfusion. The aim of this study was to compare the effects of acute administration of magnesium …

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