Michael Schwarzl

Left and Right Ventricular Hemodynamic Response After Transcatheter Mitral Valve Replacement

Sebastian Ludwig, Lena S. Strotmann, Benedikt Schrage, Benedikt Koell et autres

Background Transcatheter mitral valve replacement (TMVR) represents a novel treatment option for patients with mitral regurgitation (MR), but little is known about the hemodynamic impact of MR elimination following TMVR. We sought to investigate the hemodynamic impact of TMVR on left ventricular …

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Characteristics and Prognostic Relevance of Ventricular Arrhythmia in Patients with Myocarditis

Ann‐Kathrin Kahle, Rebekka Güde, Jana M. Schwarzl, Paula Münkler et autres

Myocarditis is characterized by various clinical manifestations, with ventricular arrhythmia (VA) as a frequent symptom at initial presentation. Here, we investigated characteristics and prognostic relevance of VA in patients with myocarditis. The study population consisted of 76 patients with myocarditis, verified by …

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Specific electrogram characteristics impact substrate ablation target area in patients with scar‐related ventricular tachycardia—insights from automated ultrahigh‐density mapping

Jana M. Schwarzl, Ruben Schleberger, Ann‐Kathrin Kahle, Alexandra Höller et autres

INTRODUCTION: Substrate-based catheter ablation approaches to ventricular tachycardia (VT) focus on low-voltage areas and abnormal electrograms. However, specific electrogram characteristics in sinus rhythm are not clearly defined and can be subject to variable interpretation. We analyzed the potential ablation target size using …

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Cellular Contribution to Left and Right Atrial Dysfunction in Chronic Arterial Hypertension in Pigs

Ge Jin, Martin Manninger, Gabriel Adelsmayr, Michael Schwarzl et autres

Abstract Aims Atrial contractile dysfunction contributes to worse prognosis in hypertensive heart disease (HHD), but the role of cardiomyocyte dysfunction in atrial remodelling in HHD is not well understood. We investigated and compared cellular mechanisms of left (LA) and right atrial (RA) …

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Risk prediction of in-hospital mortality in patients with venoarterial extracorporeal membrane oxygenation for cardiopulmonary support: The ECMO-ACCEPTS score

Peter Moritz Becher, Raphael Twerenbold, Benedikt Schrage, Bastian Schmack et autres

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Cardiac power output accurately reflects external cardiac work over a wide range of inotropic states in pigs

Dawud Abawi, Alessandro Faragli, Michael Schwarzl, Martin Manninger et autres

Abstract Background Cardiac power output (CPO), derived from the product of cardiac output and mean aortic pressure, is an important yet underexploited parameter for hemodynamic monitoring of critically ill patients in the intensive-care unit (ICU). The conductance catheter-derived pressure-volume loop area reflects …

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The role of fibroblast – Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease

David C. Bode, Diana Lindner, Michael Schwarzl, Dirk Westermann et autres

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Inflammation and fibrosis in murine models of heart failure

Lucas Bacmeister, Michael Schwarzl, Svenja Warnke, Bastian Stoffers et autres

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Macrophage Migration Inhibitory Factor (MIF) Expression Increases during Myocardial Infarction and Supports Pro-Inflammatory Signaling in Cardiac Fibroblasts

Svenja Voss, Saskia Krüger, Katharina Scherschel, Svenja Warnke et autres

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine known to play a major role in inflammatory diseases such as myocardial infarction (MI), where its expression increases. Cardio protective functions of MIF during ischemia have been reported. Recently, the structurally related MIF-2 …

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Neuron-specific-enolase as a predictor of the neurologic outcome after cardiopulmonary resuscitation in patients on ECMO

Benedikt Schrage, Nicole Rübsamen, Peter Moritz Becher, Kevin Roedl et autres

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Unloading of the Left Ventricle During Venoarterial Extracorporeal Membrane Oxygenation Therapy in Cardiogenic Shock

Benedikt Schrage, Daniel Burkhoff, Nicole Rübsamen, Peter Moritz Becher et autres

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Venoarterial Extracorporeal Membrane Oxygenation for Cardiopulmonary Support

Peter Moritz Becher, Benedikt Schrage, Christoph Sinning, Bastian Schmack et autres

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