Kevin Y.L. Yip

DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy

Ishant Khurana, Claudia H.T. Tam, Ilana Souza Correa, Scott Maxwell et autres

Gestational diabetes mellitus affects almost 18 million pregnancies worldwide, increasing by >70% in the past 20 years. DNA methylation has been associated with maternal hyperglycemia and type 2 diabetes risk in offspring. This study hypothesized that hyperglycemia during pregnancy influences DNA methylation …

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DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy

J. Assaf, Ishant Khurana, Claudia HT Tam, Ilana Souza Correa et autres

Gestational diabetes mellitus (GDM) affects almost 18 million pregnancies worldwide, increasing by more than 70% in the last 20 years. DNA methylation has been associated with maternal hyperglycaemia and type 2 diabetes (T2D) risk in offspring. This study hypothesizes that hyperglycaemia during …

DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy

Ishant Khurana, Claudia HT Tam, Ilana Souza Correa, Scott Maxwell et autres

Gestational diabetes mellitus (GDM) affects almost 18 million pregnancies worldwide, increasing by more than 70% in the last 20 years. DNA methylation has been associated with maternal hyperglycaemia and type 2 diabetes (T2D) risk in offspring. This study hypothesizes that hyperglycaemia during …

Chromosomal-level genome assembly and single-nucleotide polymorphism sites of black-faced spoonbill Platalea minor

Jerome H. L. Hui, Ting‐Fung Chan, Leo Lai Chan, Siu Gin Cheung et autres

Abstract Platalea minor , the black-faced spoonbill (Threskiornithidae) is a wading bird that is confined to coastal areas in East Asia. Due to habitat destruction, it has been classified by The International Union for Conservation of Nature (IUCN) as globally endangered species. …

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Chromosome-level genome assembly of the common chiton, Liolophura japonica (Lischke, 1873)

Jerome H. L. Hui, Ting‐Fung Chan, Leo L. Chan, Siu Gin Cheung et autres

Abstract Chitons (Polyplacophora) are marine molluscs that can be found worldwide from cold waters to the tropics, and play important ecological roles in the environment. Nevertheless, there remains only two chiton genomes sequenced to date. The chiton Liolophura japonica (Lischke, 1873) is …

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Genome assembly of the rare and endangered Grantham’s camellia, Camellia granthamiana

Jerome H. L. Hui, Ting‐Fung Chan, Leo L. Chan, Siu Gin Cheung et autres

Abstract The Grantham’s camellia ( Camellia granthamiana Sealy) is a rare and endangered tea species that is endemic to southern China, and was first discovered in Hong Kong in 1955. Despite its high conservation value, genomic resources of C. granthamiana remain limited. …

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Genome assembly of the milky mangrove Excoecaria agallocha

Jerome H. L. Hui, Ting‐Fung Chan, Leo L. Chan, Siu Gin Cheung et autres

Abstract The milky mangrove Excoecaria agallocha is a latex-secreting mangrove that are distributed in tropical and subtropical regions. While its poisonous latex is regarded as a potential source of phytochemicals for biomedical applications, the genomic resources of E. agallocha remains limited. Here, …

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Chromosomal-level genome assembly of golden birdwing Troides aeacus (Felder & Felder, 1860)

Jerome H. L. Hui, Ting‐Fung Chan, Leo Lai Chan, Siu Gin Cheung et autres

Abstract Troides aeacus , the golden birdwing (Lepidoptera, Papilionidae) is a large swallowtail butterfly widely distributed in Asia. Despite its occurrence, T. aeacus has been assigned as a major protective species in many places given the loss of their native habitats under …

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Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi et autres

Objective: This study aims to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. Research Design and Methods: We performed a two-stage genome-wide association studies for CHD in Chinese patients with T2D (3,596 cases …

hk, cn, ca (code pays fourni par la source)

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi et autres

Objective: This study aims to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. Research Design and Methods: We performed a two-stage genome-wide association studies for CHD in Chinese patients with T2D (3,596 cases …

hk, cn (code pays fourni par la source)

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi, Hoi Man Cheung et autres

OBJECTIVE: In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. RESEARCH DESIGN AND METHODS: We performed a two-stage genome-wide association study for CHD in Chinese patients with T2D …

hk, cn, ca, mo, au (code pays fourni par la source)

Abstract 868: Epigenomic profiling of primary hepatocellular carcinoma reveals super-enhancer-associated chromatin regulator network

Liangliang Xu, Feng Wu, Otto Ka-Wing Cheung, Lemuel L. M. Szeto et autres

Abstract Hepatocellular carcinoma (HCC) is the second most common cause of cancer mortality worldwide. Parallel with the growing epidemics of obesity and diabetes, non-alcoholic fatty liver disease (NAFLD) has become the predominant cause leading to HCC in a dysregulated metabolic background. Recent …

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