Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes
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Le résumé fourni par la source
Objective: This study aims to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. Research Design and Methods: We performed a two-stage genome-wide association studies for CHD in Chinese patients with T2D (3,596 cases and 8,898 controls), followed by replications in European patients with T2D (764 cases and 4,276 controls) and general populations (n=51,442-547,261). Each identified variant was examined for its association with a wide range of phenotypes, and its interactions with glycaemic, blood pressure (BP) and lipid controls on incident cardiovascular diseases. Results: We identified a novel variant (rs10171703) for CHD (OR [95% CI] = 1.21 [1.13–1.30]; P=2.4×10-8) and BP (β±SE = 0.130±0.017; P = 4.1×10-14) at PDE1A in Chinese T2D patients, but found only a modest association with CHD in general populations. This variant modulated the effects of BP goal attainment (130/80 mmHg) on CHD (Pinteraction = 0.0155) and myocardial infarction (MI) (Pinteraction = 5.1×10-4). Patients with CC-genotype of rs10171703 had >40% reduction in either cardiovascular events in response to BP control (2.9×10-8 < P < 3.6×10-5), those with CT-genotype had no difference (0.0726 < P < 0.2614), and those with TT-genotype had a threefold increase in MI risk (P = 6.7×10-3). Conclusions: We discovered a novel CHD- and BP-related variant at PDE1A which interacted with BP goal attainment with divergent effects on CHD risk in Chinese patients with T2D. Incorporating this information may facilitate individualized treatment strategies for precision care in diabetes only when our findings are validated.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <strong>Identification of a Common Variant for Coronary Heart Disease at</strong> <em><strong>PDE1A</strong></em> <strong>Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes</strong>
- Date Crossref
- 04/05/2023
- Éditeur
- American Diabetes Association
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese University of Hong Kong Department of Medicine and Therapeutics pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Jiao Tong University pays non établi dans la noticeUniversité ou école supérieure
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Our Lady of Maryknoll Hospital Centre for Diabetes Education and Management pays non établi dans la noticeÉtablissement de santé
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Kwong Wah Hospital Department of Medicine and Geriatrics pays non établi dans la noticeÉtablissement de santé
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Hospital for Sick Children The Centre for Applied Genomics pays non établi dans la noticeÉtablissement de santé
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Alice Ho Miu Ling Nethersole Hospital pays non établi dans la noticeÉtablissement de santé
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Centre for Applied Genomics pays non établi dans la noticeStructure de recherche
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Hong Kong University of Science and Technology Department of Electronic and Computer Engineering pays non établi dans la noticeUniversité ou école supérieure
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Ruttonjee Hospital Department of Medicine and Geriatrics pays non établi dans la noticeÉtablissement de santé
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United Christian Hospital Department of Medicine and Geriatrics pays non établi dans la noticeÉtablissement de santé
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Tseung Kwan O Hospital pays non établi dans la noticeÉtablissement de santé
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Yan Chai Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
Department of Medicine and Therapeutics — Chinese University of Hong Kong, Shanghai Jiao Tong University et Centre for Diabetes Education and Management — Our Lady of Maryknoll Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.