Wenhua Su

Association of TNNI3 and MYBPC3 variants with clinical phenotype and metabolic disorders in patients with hypertrophic cardiomyopathy

H B Wu, Qiuyue Yu, Huimin Li, Z L Yang et autres

INTRODUCTION: Hypertrophic cardiomyopathy is an inherited cardiovascular disease with heterogeneous presentation. However, the metabolic changes resulting from mutations and their relationship to the phenotype remain unclear. OBJECTIVES: To investigate the association between TNNI3 and MYBPC3 variants and both clinical phenotype and metabolic …

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Plasma metabolic profiling reveals exploratory metabolic differences in chronic coronary syndrome with coronary artery calcification

Xiaoxue Ding, H B Wu, Mingjie Pang, Shiqi Liu et autres

Background/objectives: Coronary artery calcification (CAC) is a specific marker of coronary atherosclerotic heart disease, with chronic coronary syndrome (CCS) being a primary clinical manifestation of coronary artery disease. However, research on the plasma metabolites of individuals with CCS and CAC, as well …

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Integrated Traditional Chinese and Western Medicine Treatment Protocol for Atherosclerosis

Hetao Chen, Zheng Yang, Yang Xie, Xiaoxue Ding et autres

Atherosclerosis is the common pathological basis of various cardiovascular and cerebrovascular events. It is characterized by insidious onset, slow progression, extensive vascular involvement, and a high risk of disability and death, posing a serious threat to public health and increasing the social …

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Bak inserts into Mcl-1-puma and Mcl-1-BimL dimers to form hetero-trimers analyzed using quantitative live-cell FRET imaging

Hongce Chen, Wenhua Su, Lingyu Wang, Zhirui Wu et autres

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The associations among genetic features, late gadolinium enhancement and prognosis in hypertrophic cardiomyopathy

Wenhua Su, Hao Wu, Chen Chen, Hongjiang Zhang et autres

Aims To assess the combined prognostic value of genotype and late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients, including those with preserved left ventricular ejection fraction (LVEF). Methods In 135 HCM patients (age 52.43 ± 11.35 years, 79.26% male), whole-exome sequencing, …

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Clinical Features of Patients with Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease and Isolated Seizure Symptoms

Yun Yang, Chao Zhang, Chen Cao, Wenhua Su et autres

Background: Myelin oligodendrocyte glycoprotein (MOG) antibody–associated encephalitis is a new clinical phenotype of inflammatory demyelinating diseases. Some MOG antibody–positive patients with central nervous system demyelinating events present with isolated seizures. However, there are gaps in the epidemiological knowledge regarding seizures with MOG …

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Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression

Yang Sun, Lujun Zhang, Yu Qing Cao, Xingsheng Li et autres

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Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury

Saira Hameed, Kun Pan, Wenhua Su, Miles Trupp et autres

While it is known that air borne ultrafine particulate matter (PM) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanism and effects are not completely clear. In this …

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Label-free biocompatible detection and quantification of airborne particulate matter (PM2.5) and chronic tissue injury in heart and lung of mouse

Saira Hameed, Kun Pan, Wenhua Su, Miles Trupp et autres

Abstract While it is known that air borne particulate matter (PM2.5) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanism and effects are not completely clear. In this …

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AgInS2/ZnS quantum dots for noninvasive cervical cancer screening with intracellular pH sensing using fluorescence lifetime imaging microscopy

Wenhua Su, Dan Yang, Yulan L. Wang, Yawei Kong et autres

Intracellular pH plays a critical role in biological functions, and abnormal pH values are related to various diseases. Here, we report on an intracellular pH sensor AgInS 2 (AIS)/ZnS quantum dots (QDs) that show long fluorescence lifetimes of hundreds of nanoseconds and …

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Macrophage Paired Immunoglobulin-Like Receptor B Deficiency Promotes Peripheral Atherosclerosis in Apolipoprotein E–Deficient Mice

Wenhua Su, Liwen Liang, Liang Zhou, Yu Cao et autres

Background: Peripheral atherosclerotic disease (PAD) is the narrowing or blockage of arteries that supply blood to the lower limbs. Given its complex nature, bioinformatics can help identify crucial genes involved in the progression of peripheral atherosclerosis. Materials and Methods: Raw human gene …

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The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis

Rongzhong Huang, Zicheng Hu, Xiaorui Chen, Yu Cao et autres

Abstract Toll‐like receptor 2 and 4 (TLR2, TLR4) signaling is implicated in atherosclerotic plaque formation. The two‐stage master regulator Virtual Inference of Protein‐activity by Enriched Regulon (VIPER) analysis of macrophage TLR2 and TLR4 signature genes integrated with coexpression network genes derived from …

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