Lujun Zhang

1350-P: Impact of Glycemia, Sleep, Physical Activity on Hypoglycemia Counterregulation in Type 1 Diabetes

Elizabeth R. Seaquist, ANJALI KUMAR, Lujun Zhang, Brent Strong et autres

Introduction and Objective: How glucose variability, sleep, physical activity modify risk of impaired awareness of hypoglycemia in T1D is unclear. We investigated associations between prior week CGM and actigraphy with epinephrine and symptom responses to recurrent hypoglycemia (HG) in aware participants with …

Impact of recurrent hypoglycemia on brain glucose transport kinetics in type 1 diabetes

Elizabeth R. Seaquist, Young Woo Park, Achint Kumar, Alison Alvear et autres

CONTEXT: Impaired awareness of hypoglycemia (IAH) significantly impacts efforts to maintain optimal glycemia. IAH occurs when recurrent episodes of hypoglycemia (HG) occur within a short period of time, but the mechanisms are unknown. Upregulation of glucose transport may contribute to the development …

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369-P: Exposure to Recurrent Hypoglycemia Does Not Alter Brain Glucose Transport Kinetics in Type 1 Diabetes (T1D)

Elizabeth R. Seaquist, Young Woo Park, Anjali Kumar, Lujun Zhang et autres

Introduction and Objective: Mechanisms of impaired awareness of hypoglycemia (IAH) upon exposure to recurrent hypoglycemia (HG) in people with T1D are unknown. We tested the hypothesis that brain glucose transport is upregulated in response to recurrent HG, obviating the need to mount …

Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition

Lujun Zhang, Yang-Xi Hu, Rongzhong Huang, Yanyan Xu et autres

AIMS: MicroRNA-126 (miR-126), one of the most abundant microRNAs in platelets, is involved in the regulation of platelet activity and the circulating miR-126 is reduced during antiplatelet therapy. However, whether intraplatelet miR-126 plays a role in thrombosis and platelet inhibition remains unclear. …

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Dual Antiplatelet Therapies and Causes in Minor Stroke or Transient Ischemic Attack: A Prespecified Analysis in the CHANCE-2 Trial

Xuewei Xie, Jing Jing, Xia Meng, S. Claiborne Johnston et autres

BACKGROUND: It is unclear whether patients with different stroke/transient ischemic attack etiologies benefit differently from gene-directed dual antiplatelet therapy. This study explored the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in transient ischemic attack or minor stroke with different causes in the …

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Multi-stage nuclear transcriptomic insights of morphogenesis and biparental role changes in Lentinula edodes

Xiaoxia Song, Mingjie Chen, Yan Zhao, Meiyan Zhang et autres

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Anti-CXCR2 antibody-coated nanoparticles with an erythrocyte-platelet hybrid membrane layer for atherosclerosis therapy

Rongzhong Huang, Lujun Zhang, Xingsheng Li, Fan Liu et autres

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Stroke-induced hexokinase 2 in circulating monocytes exacerbates vascular inflammation and atheroprogression

Yang Sun, Lujun Zhang, Yu Qing Cao, Xingsheng Li et autres

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Di-(2-ethylhexyl) phthalate impairs angiogenesis and hematopoiesis via suppressing VEGF signaling in zebrafish

Yang-Xi Hu, Bowen Hu, Ya-Sha Chen, Hong-Min You et autres

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Proangiogenesis effects of compound danshen dripping pills in zebrafish

Yang-Xi Hu, Hong-Min You, Changzhen Ren, Bowen Hu et autres

BACKGROUND: The compound Danshen Dripping Pill (CDDP), which is a mixture of extracts from Radix Salviae and Panax notoginseng, is a patented traditional Chinese medicine that is widely used in multiple countries for relieving coronary heart disease (CHD), but its pharmacological mechanism …

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Transcriptomic Analysis of Two Lentinula edodes Genotypes With Different Cadmium Accumulation Ability

Hailong Yu, Qiaozhen Li, Xiufen Shen, Lujun Zhang et autres

Lentinula edodes, also known as Xiang’gu, is commonly eaten in cultures around the world. However, L. edodes is particularly susceptible to enrichment with heavy metals, particularly cadmium (Cd), which is toxic to human health. Understanding the molecular mechanism and mining key genes …

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A novel hippocampus metabolite signature in diabetes mellitus rat model of diabetic encephalopathy

Guang‐Hui Chen, Yizhong Wang, Yang Li, Lujun Zhang et autres

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